Mucosa-Associated Lymphoid Tissue Type Lymphoma of the Gallbladder Associated with Acute Myeloid Leukemia.

Abstract

Wedescribe a patient with mucosa-associated lymphoid tissue (MALT)type lymphoma of the gallbladder who developed concurrent acute myeloid leukemia (M2). She was admitted because of progressive jaundice and underwent cholecystectomy. Histologic examination of the gallbladder showed diffuse proliferation of atypical lymphoid cells and a formed lymphoepithelial lesion. Because of progressive thrombocytopenia, a bone marrow tap was performed 25 days after the operation. Bone marrow contained 65.5% blasts, and was positive for peroxidase, CD33 and HLA-DR, and negative for lymphoid markers. Wediscuss the rare association of these disorders. (Internal Medicine 38: 442-444, 1999)

Acute myeloid leukaemia presenting as cholestatic hepatitis

“…3 Most case reports of jaundice in AML are the result of obstructive jaundice secondary to granulocytic sarcoma. [3][4][5] Our patient is atypical in that he had interesting hepatic histology with diffuse sinusoidal infiltration of the liver by leukaemic cells. Although our patient was on longterm antidepressant treatment (paroxetine), which can cause liver dysfunction, we confirmed leukaemic infiltration of the liver by liver biopsy.…”

Gallbladder lymphoma in a miniature dachshund

“…The most common clinical symptom in human patients with gallbladder lymphoma is upper abdominal pain [1, 3, 5,6,7,8, 10, 11, 14,15,16, 18]. One of 2 cats with gallbladder lymphoma also showed a pain response with palpation of the cranial abdomen [7].…”

Primary mucosa-associated lymphoid tissue lymphoma of the gallbladder: report of a case harboring API2/MALT1 gene fusion

“…Slightly more than half of the cases were associated with gallbladder stones and/or chronic cholecystitis, recalling the relationship between MALT lymphomas and chronic inflammatory conditions at other anatomical sites. Except for one case in which Enterococcus faecalis and Morganella morganii were identified in bile cultures [5], there was no evidence of microorganisms in the other cases. The origin of E coli demonstrated in blood cultures in our case is uncertain, because there were no features suggestive of a bacterial infection and no microorganisms identified on gallbladder sections.…”

“…Before the current report, only 9 cases of MALT lymphoma primarily involving the gallbladder and fulfilling confident diagnostic criteria have been described in the literature (Table 1) [5][6][7][8][9][10][11][12][13]. Overall, MALT lymphomas of the gallbladder appear to occur predominantly in elderly women (median age, 69.5 years; male to female, 1-4).…”

“…Of the few cases reported in the literature, none has been documented at the genetic level [5][6][7][8][9][10][11][12][13]. Here, we report a case of primary MALT lymphoma of the gallbladder with evidence of API2/MALT1 gene fusion, indicative of a t(11;18)(q21;q21) translocation.…”