Mucosal and systemic immunization elicited by Newcastle disease virus (NDV) transgenic plants as antigens

Berinstein, Analía; Rovere, Cecilia Vázquez; Asurmendi, Sebastián; Gómez, Emma Laura Alfaro; Zanetti, Flavia; Zábal, Osvaldo; Tozzini, Alejandro C.; Grand, Daniela Conte; Taboga, Oscar; Calamante, Gabriela; Barrios, H A; Hopp, H. Esteban; Carrillo, Elisa

doi:10.1016/j.vaccine.2005.06.033

Cited by 62 publications

(33 citation statements)

References 26 publications

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“…Different systems have been employed to express antigenic NDV proteins as potential vaccines. Recently, antigenic NDV proteins have been expressed in potato and seroconversion measured in mice (Berinstein et al 2005). Neutralizing epitopes from the F protein or the HN protein have been fused to the capsid protein of the cucumber mosaic virus but no immunological analysis was performed (Zhao and Hammond 2005).…”

Section: Discussionmentioning

confidence: 99%

Expression of the Newcastle disease virus fusion protein in transgenic maize and immunological studies

et al. 2006

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Transgenic plants have been employed successfully as a low-cost system for the production of therapeutically valuable proteins, including antibodies, antigens and hormones. Here, we report the expression of the fusion (F) gene of the Newcastle disease virus (NDV) in transgenic maize plants. The expression of the transgene, driven by the maize ubiquitin promoter, caused accumulation of the F protein in maize kernels. The presence of the transgene was verified by Southern and western blots. Feeding chickens with kernels containing the F protein induced the production of antibodies, which conferred protection against a viral challenge. This protection was comparable to that conferred by a commercial vaccine. Possible uses of this plant-based F protein as a potential mucosal vaccine are discussed.

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Section: Discussionmentioning

confidence: 99%

Expression of the Newcastle disease virus fusion protein in transgenic maize and immunological studies

et al. 2006

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“…Other approaches include the development of subunit vaccines based on the large scale expression of NDV proteins (usually F and/or HN) using baculovirus vectors (Fukanoki et al, 2001;Lee et al, 2008;Mori et al, 1994;Nagy et al, 1991) or plants (Berinstein et al, 2005;Yang et al, 2007) and the use of DNA vaccines, i.e. plasmid DNA encoding relevant immunogenic NDV proteins (Loke et al, 2005;Rajawat et al, 2008).…”

Section: I) For Animal Productionmentioning

confidence: 99%

Seroprevalence of Paramyxoviruses in Synanthropic and Semi–Free-Range Birds

Esperón¹,

Vázquez²,

Sánchez³

et al. 2014

Avian Diseases

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“…The use of transgenic plants for the expression of different antigens has been increasingly employed for the production of experimental immunogens. Several authors have reported antibody response to parenterally or orally administered plantderived antigens [15][16][17][18][19][20][21]. The demonstration that many proteins from pathogens, including those expressed in transgenic plants, are immunogenic when administered orally, has encouraged the study of other antigens expressed in plants with the goal of developing edible vaccines.…”

Section: Introductionmentioning

confidence: 99%

Developments in Plant-Based Vaccines Against Diseases of Concern in Developing Countries

Gómez¹,

Zoth²,

Carrillo³

et al. 2010

TOIDJ

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Vaccination has been extensively used to prevent, eradicate and control infectious diseases. However, the development and implementation of new vaccines remains prohibitively expensive for middle and low income countries where such measures are surely needed most. The production of plant-based vaccines provides a promising alternative to create affordable biological products. In the past decade, a growing number of research groups worldwide have studied plant expression and parenteral or oral delivery of vaccine antigens, some showing promising potential. Here, we describe the basis of the system and the state of the art of developments regarding diseases of concern in developing countries.

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Mucosal and systemic immunization elicited by Newcastle disease virus (NDV) transgenic plants as antigens

Cited by 62 publications

References 26 publications

Expression of the Newcastle disease virus fusion protein in transgenic maize and immunological studies

Expression of the Newcastle disease virus fusion protein in transgenic maize and immunological studies

Seroprevalence of Paramyxoviruses in Synanthropic and Semi–Free-Range Birds

Developments in Plant-Based Vaccines Against Diseases of Concern in Developing Countries

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