Mucosal-Associated Invariant T Cells Are Altered in Patients with Hidradenitis Suppurativa and Contribute to the Inflammatory Milieu

Gallagher, Catriona; Mahon, Julie Mac; O'Neill, Chloe; Cassidy, Féaron C.; Dunbar, Hazel; Barra, Conor De; Cadden, Caoimhe; Pisarska, Marta M.; Wood, Nicole; Masterson, Joanne C.; McNamee, Eoin N.; Schrumpf, Elisabeth; English, Karen; O’Shea, Donal; Tobin, Anne Marie; Hogan, Andrew E.

doi:10.1016/j.jid.2022.11.011

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…Since their discovery and characterization, MAIT cells have been investigated in numerous chronic disease settings, from multiple sclerosis to psoriasis to several types of connective tissue diseases, often implicated in pathogenesis (50)(51)(52)(53)(54)(55). One of the most investigated disease clusters has been the metabolic diseases; with studies in obesity, diabetes (both type 1 and 2), non-alcoholic fatty liver disease and cardiovascular disease (46,47,(56)(57)(58)(59).…”

Section: Systemic Metabolism and Mait Cellsmentioning

confidence: 99%

MAITabolism2 – the emerging understanding of MAIT cell metabolism and their role in metabolic disease

Kedia-Mehta

Hogan²

2023

Front. Immunol.

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Mucosal associated invariant T (MAIT) cells are a population of unconventional innate T cells due to their non-MHC restriction and rapid effector responses. MAIT cells can recognise bacterial derived antigens presented on the MHC-like protein via their semi-restricted T cell receptor (TCR). Upon TCR triggering MAIT cells rapidly produce a range of effector molecules including cytokines, lytic granules and chemokines. This rapid and robust effector response makes MAIT cells critical in host responses against many bacterial pathogens. MAIT cells can also respond independent of their TCR via innate cytokines such as interleukin (IL)-18, triggering cytokine production, and are important in anti-viral responses. In addition to their protective role, MAIT cells have been implicated in numerous inflammatory diseases, including metabolic diseases often contributing to the pathogenesis via their robust cytokine production. Effector cells such as MAIT cells require significant amounts of energy to support their potent responses, and the type of nutrients available can dictate the functionality of the cell. Although data on MAIT cell metabolism is just emerging, several recent studies are starting to define the intrinsic metabolic requirements and regulators of MAIT cells. In this review we will outline our current understanding of MAIT cell metabolism, and outline their role in metabolic disease, and how disease-related changes in extrinsic metabolism can alter MAIT cell responses.

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Section: Systemic Metabolism and Mait Cellsmentioning

confidence: 99%

MAITabolism2 – the emerging understanding of MAIT cell metabolism and their role in metabolic disease

Kedia-Mehta

Hogan²

2023

Front. Immunol.

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“…Particularly in the dermis of psoriatic skin lesions, MAIT cells express high levels of IL-17 and granzyme B [76][77][78]. In line with an CCR6 + MAIT17 phenotype, MAIT cells migrate in response to CCL20, which is produced in psoriatic lesions, indicating skin infiltration of MAIT cells via the CCL20/CCR6 axis [79]. In contrast to other IMIDs, the frequency of circulating MAIT cells is not significantly changed in psoriasis vulgaris patients [80].…”

Section: Skin Diseasementioning

confidence: 99%

MAIT cells in immune‐mediated tissue injury and repair

Waterhölter,

Wunderlich,

Turner

2023

Eur J Immunol

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Mucosal‐associated invariant T (MAIT) cells are T cells that express a semi‐invariant αβ T cell receptor (TCR), recognising non‐peptide antigens, such as microbial‐derived Vitamin B2 metabolites, presented by the non‐polymorphic MHC class I related‐1 molecule (MR1). Like NKT cells and γδT cells, MAIT cells belong to the group of innate‐like T cells that combine properties of the innate and adaptive immune systems. They account for up to 10% of the blood T‐cell population in humans and are particularly abundant at mucosal sites. Beyond the emerging role of MAIT cells in antibacterial and antiviral defences, increasing evidence suggests additional functions in non‐infectious settings, including immune‐mediated inflammatory diseases and tissue repair.Here, we discuss recent advances in the understanding of MAIT cell functions in sterile tissue inflammation, with a particular focus on autoimmunity, chronic inflammatory diseases, and tissue repair.This article is protected by copyright. All rights reserved

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“…A similar finding was published in the case of patients with a chronic HIV-1 infection, where Vα7.2 + /CD161 − accumulated and MAIT cells decreased compared to in uninfected healthy controls, despite an unchanged total T cell number [ 13 ]. The active roles of MAIT cell subsets were identified in the pathogenesis of skin diseases, such as psoriasis and hidradenitis suppurativa, where they were found to be another alternative source of IL-17, increasing the severity of disease [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Investigating Vα7.2+/CD161− T Cell and MAIT Cell Profiles Using Flow Cytometry in Healthy Subjects and Subjects with Atopic Dermatitis

Singh,

Gaspar,

Szegedi

et al. 2024

IJMS

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This study investigates the roles of mucosal-associated invariant T (MAIT) cells and Vα7.2+/CD161− T cells in skin diseases, focusing on atopic dermatitis. MAIT cells, crucial for bridging innate and adaptive immunity, were analyzed alongside Vα7.2+/CD161− T cells in peripheral blood samples from 14 atopic dermatitis patients and 10 healthy controls. Flow cytometry and machine learning algorithms were employed for a comprehensive analysis. The results indicate a significant decrease in MAIT cells and CD69 subsets in atopic dermatitis, coupled with elevated CD38 and polyfunctional MAIT cells producing TNFα and Granzyme B (TNFα+/GzB+). Vα7.2+/CD161− T cells in atopic dermatitis exhibited a decrease in CD8 and IFNγ-producing subsets but an increase in CD38 activated and IL-22-producing subsets. These results highlight the distinctive features of MAIT cells and Vα7.2+/CD161− T cells and their different roles in the pathogenesis of atopic dermatitis and provide insights into their potential roles in immune-mediated skin diseases.

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Mucosal-Associated Invariant T Cells Are Altered in Patients with Hidradenitis Suppurativa and Contribute to the Inflammatory Milieu

Cited by 4 publications

References 38 publications

MAITabolism2 – the emerging understanding of MAIT cell metabolism and their role in metabolic disease

MAITabolism2 – the emerging understanding of MAIT cell metabolism and their role in metabolic disease

MAIT cells in immune‐mediated tissue injury and repair

Investigating Vα7.2+/CD161− T Cell and MAIT Cell Profiles Using Flow Cytometry in Healthy Subjects and Subjects with Atopic Dermatitis

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