Mucosal chemokine CXCL17: What is known and not known

Xiao, Shiyu; Xie, Wenhui; Zhou, Liya

doi:10.1111/sji.12965

Cited by 30 publications

(24 citation statements)

References 40 publications

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“…Up to date, 43 chemokines, not counting isoforms, are known in human (2). The latest addition to the chemokine family is mucosal CXC-type chemokine CXCL17 (3). Although the body of literature about CXCL17 is growing and now includes several dozens of published articles focusing on or referring to it, belonging of this protein to the chemokine family remains debatable.…”

Section: Introductionmentioning

confidence: 99%

CXCL17: The Black Sheep in the Chemokine Flock

Denisov

2021

Front. Immunol.

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Section: Introductionmentioning

confidence: 99%

CXCL17: The Black Sheep in the Chemokine Flock

Denisov

2021

Front. Immunol.

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Section: Discussionmentioning

confidence: 99%

“…Our findings add to the recently identified expression of CXCL17 in the kidney 37 , the last identified member of the CXC chemokine family in mammals 38,39 . CXCL17 attracts professional antigen presenting cells 40 , including macrophages, through its receptor CXCR8. Very little is known about the role of CXCL17 in the kidney but single-cell RNA sequencing analysis revealed that CXCL17 expression is enhanced at an early time point in murine tubulointerstitial fibrosis model 37 . CX3CL1, which binds to CX3CR1, plays a major role in the recruitment of resident macrophage during kidney development 41 and may increase renal macrophage abundance by prolonging their survival 42 .…”

Section: Discussionmentioning

confidence: 99%

“…Our findings add to the recently identified expression of CXCL17 in the kidney 42 , the last identified member of the CXC chemokine family in mammals 43,44 . CXCL17 attracts professional antigen presenting cells 45 , including macrophages, through its suspected receptor GPR35/CXCR8 46 , even though a second unidentified G protein-coupled receptor may mediate CXCL17-dependent signaling 47 . Although very little is known about the role of CXCL17 in the kidney, single-cell RNA sequencing analysis revealed that its expression is enhanced at an early time point in murine tubulointerstitial fibrosis model 42 .…”

Section: Discussionmentioning

confidence: 99%

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The renal inflammatory network of nephronophthisis

Quatredeniers

Bienaimé

Ferri

et al. 2021

Preprint

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Nephronophthisis (NPH) and autosomal dominant polycystic kidney disease (ADPKD) are caused by mutations in genes encoding primary cilia proteins. In ADPKD, altered cilia signaling promotes renal inflammation through the upregulation of the macrophage chemoattractant CCL2, which subsequently fuels disease progression. While inactivation of NPHP1, the main gene involved in NPH leads to increased CCL2 expression in cultured renal epithelial cells, little is known about renal inflammation in NPH.Here, we analyzed murine models of NPH as well as kidney tissues and urine derived renal epithelial cells (UREC) from NPH patients to dissect the renal inflammatory network involved in NPH.Similarly to ADPKD, NPH patients present kidney infiltration by macrophages, increased CCL2 expression by tubular cells and enhanced CCL2 urinary excretion. Yet, while tubule specific Ccl2 disruption dramatically reduced renal Ccl2 expression in a mouse model of NPH, this did not translate into reduced macrophage infiltration nor lessened renal deterioration. In further contrast to early ADPKD, infiltrating macrophages were accompanied by neutrophils and T cells in both human and murine NPH. Through analysis of transcriptome datasets from early diseased kidneys in two distinct mouse models of NPH, we identified a set of 17 soluble inflammatory mediators, which increased independently of CCL2. Among those, 8 were also significantly upregulated in UREC from NPH patients compared to controls.Collectively, these results unveil that mutations in ciliary proteins in NPH and ADPKD trigger divergent renal inflammatory responses. This work sheds light on the specific inflammatory network underlying NPH.

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“…Previous studies have shown that the expression level of CXCL17 and its receptor CXCR8 in liver carcinoma, breast cancer and colon carcinoma is higher than in adjacent tissues [5][6][7], Saqhir et al found that CXCL17 is one of the upregulated genes in gene expression profile analysis of endometrial cancer patients and healthy people, and its mRNA was detected at a high level in type I endometrial cancer, but no further study was carried out. CXCL17, first discovered in 2006, is a CXC chemokine, that may play a role in the development of endometrial carcinoma, which is named dendritic cell monocyte chemoattractant protein (DMC) or vascular endothelial growth factor-related chemokine-1 (VCC-1) according to its functional characteristics [8]. It has the function of recruiting immune cells, strong anti-inflammatory and antibacterial abilities, chemotaxis, immune dynamic balance regulation and tumor immune response [9].…”

Section: Introductionmentioning

confidence: 99%

Expression and clinical significance of CXCL17 and GPR35 in endometrial carcinoma

et al. 2022

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Endometrial carcinoma is one of the most common gynecologic malignancies. CXCL17-CXCR8 (GPR35) axis is reported to play an indispensability role in tumors. Our purpose is to screen possible prognostic and immune-related factors in endometrial carcinoma by detecting the mRNA and protein expression of CXCL17 and CXCR8. We use the qRT-PCR method to test the mRNA expression of CXCL17 and CXCR8 in 35 pairs of endometrial carcinoma and adjacent tissue. The protein expression of CXCL17 and CXCR8 in 30 cases of normal proliferative endometrium, 30 cases of endometrial atypical hyperplasia and 50 cases of endometrial carcinoma was detected by tissue microarray immunohistochemistry. There was no significant difference in the positive expression rate between endometrial adenocarcinoma tissue and endometrial atypical hyperplasia tissue (P > 0.05). But significantly better than normal proliferative tissue (P < 0.001). Correlation analysis of CXCR8 and CXCL17 in endometrial carcinoma showed a positive correlation (r = 0.9123, P < 0.0001). For patients with endometrial cancer, the overall survival (OS) of patients with high CXCL17 expression was significantly higher than that low CXCL17 expression (log-rank test, P < 0.0001), whereas CXCR8 had no statistical significance. But the expression of CXCR8 is an independent prognostic factor of OS in endometrial carcinoma patients. Our study showed that CXCL17 and CXCR8 may be involved in the occurrence and development of endometrial cancer. High expression of CXCL17 may be used as a biomarker for predicting survival. Because CXCL17 and CXCL18 are related to lymphocytes and immune regulation, they are expected to become potential targets for immunotherapy.

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Mucosal chemokine CXCL17: What is known and not known

Cited by 30 publications

References 40 publications

CXCL17: The Black Sheep in the Chemokine Flock

CXCL17: The Black Sheep in the Chemokine Flock

The renal inflammatory network of nephronophthisis

Expression and clinical significance of CXCL17 and GPR35 in endometrial carcinoma

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