Mucosal IgA production and lymph cell traffic following prolonged low level infections of Ostertagia circumcincta in sheep

Smith, William D.; Jackson, F.; Graham, Robert B.; Jackson, Elizabeth B.; Williams, James T.

doi:10.1016/s0034-5288(18)30801-4

Cited by 19 publications

(8 citation statements)

References 10 publications

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“…At that time there was little evidence of a strong lymphoblast response (W.D. Smith, personal communication) although, previously, rapid and simultaneous outputs of both blast and IgA cells have been noted during the first few days after challenge of previously exposed lambs [22].…”

Section: Discussionmentioning

confidence: 94%

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Local eosinophil- and mast cell-related responses in abomasal nematode infections of lambs

Stevenson

1994

FEMS Immunology and Medical Microbiology

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Eosinophil numbers in peripheral blood and eosinophil potentiating activity (EPA) and sheep mast cell protease (SMCP) in efferent gastric lymph were monitored in lambs during infections with Ostertagia circumcincta. Worm burdens, eosinophil numbers in bone marrow, abomasal mucosa and gastric lymph node, as well as mast cell numbers and SMCP concentrations in mucosa and mucus, were determined in post mortem samples. In naive lambs, high and relatively uniform worm burdens were present 10 days after primary infection and these were associated with only mild blood and tissue eosinophilia. By day 21 worm burdens were markedly lower and more variable. There was more evidence of eosinophil and mast cell accumulation in mucosa, and numbers in bone marrow were also higher than on day 10. However, neither EPA nor SMCP were detectable in lymph. By contrast, EPA and SMCP were present in substantial amounts in draining lymph within 48 h of challenge (secondary) infection of previously exposed lambs. EPA was inversely related to worm burdens recovered on day 10, as were abomasal mucosal and mucus SMCP concentrations. Elevated eosinophil numbers were also consistently detected in blood, bone marrow, mucosa and gastric lymph node. The results suggest that host immune defence against secondary, but not primary, exposure to O. circumcincta involves a rapidly mobilised local inflammatory component.

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Section: Discussionmentioning

confidence: 94%

“…1). Previous work suggests that the first major immunological consequences in lymph following primary exposure of lambs to O. circumcincta are increased lymphoblast and IgA cell outputs [22].…”

Section: Discussionmentioning

confidence: 99%

Local eosinophil- and mast cell-related responses in abomasal nematode infections of lambs

Stevenson

1994

FEMS Immunology and Medical Microbiology

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“…Sheep infected with T. circumcincta can acquire protective immunity (3–6), so vaccination may be a viable alternative control method (7–10). Manifestations of immunity to T. circumcincta include exclusion or expulsion of incoming third stage larvae (L3), inhibited development at the early fourth stage (EL4), retardation of adult worm growth and reduced fecundity (3,11,12).…”

Section: Introductionmentioning

confidence: 99%

Parasite loss and inhibited development of Teladorsagia circumcincta in relation to the kinetics of the local IgA response in sheep

Halliday

Routledge

Smith

et al. 2007

Parasite Immunology

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Groups of yearling sheep, which had been trickle infected with Teladorsagia circumcincta for 8 weeks and then drenched, were challenged with 50 000 T. circumcincta larvae together with groups of worm-free controls. Fewer parasites and a greater proportion of early fourth stage larvae were recovered from previously infected sheep compared to controls. Worm loss and arrested development were evident by 5 days after challenge whereas growth retardation of developing worms was observed by day 10. In the previously infected sheep a secondary IgA response was observed in the efferent gastric lymph from 5 days post-infection. Western blot analysis showed the lymph IgA to be predominantly dimeric and nonsecretory in nature and that the somatic antigens recognized were predominantly in the 100-250 kDa range. The concentration of IgA in lymph was always higher than in blood and in the previously infected sheep increased fivefold 8 days post-challenge in contrast to blood where IgA levels were unchanged. The timing of the response suggested that it occurred too late to have been the cause of worm loss or arrested development, though it may have retarded the growth of developing parasites.

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“…Temporary interruption of the challenge in a second group of previously infected sheep showed that elevated IgA and pepsinogen values were maintained only if larval intake was continuous (Smith, Jackson, Graham, Jackson and Williams 1987). The sheep were highly immune to this type of challenge and only a few inhibited parasites were found at slaughter.…”

Section: Size and Frequency Of Challenge Dosementioning

confidence: 96%

Increasing Small Ruminant Productivity in Semi-arid Areas

Thomson¹,

Thomson²

1988

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Mucosal IgA production and lymph cell traffic following prolonged low level infections of Ostertagia circumcincta in sheep

Cited by 19 publications

References 10 publications

Local eosinophil- and mast cell-related responses in abomasal nematode infections of lambs

Local eosinophil- and mast cell-related responses in abomasal nematode infections of lambs

Parasite loss and inhibited development of Teladorsagia circumcincta in relation to the kinetics of the local IgA response in sheep

Increasing Small Ruminant Productivity in Semi-arid Areas

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