1994
DOI: 10.1016/0928-8244(94)90042-6
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Local eosinophil- and mast cell-related responses in abomasal nematode infections of lambs

Abstract: Eosinophil numbers in peripheral blood and eosinophil potentiating activity (EPA) and sheep mast cell protease (SMCP) in efferent gastric lymph were monitored in lambs during infections with Ostertagia circumcincta. Worm burdens, eosinophil numbers in bone marrow, abomasal mucosa and gastric lymph node, as well as mast cell numbers and SMCP concentrations in mucosa and mucus, were determined in post mortem samples. In naive lambs, high and relatively uniform worm burdens were present 10 days after primary infe… Show more

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Cited by 9 publications
(8 citation statements)
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“…Moreover, a significant eosinophilic exocytosis was shown in the sinus cavities, possibly suggesting that these cells were passing through the epithelium to reach the larvae. Similar local cellular responses have been observed in the skin of sheep infected with Lucilia cuprina larvae [1] or in the gut mucosae of sheep infected with gastrointestinal nematodes [13,19]. The numerous plasma cells found in the O. ovis infected animals were likely to be responsible for the local IgG and IgA responses, even though specific staining to characterise the immunoglobulin isotypes was not [9,21].…”
Section: Discussionsupporting
confidence: 52%
“…Moreover, a significant eosinophilic exocytosis was shown in the sinus cavities, possibly suggesting that these cells were passing through the epithelium to reach the larvae. Similar local cellular responses have been observed in the skin of sheep infected with Lucilia cuprina larvae [1] or in the gut mucosae of sheep infected with gastrointestinal nematodes [13,19]. The numerous plasma cells found in the O. ovis infected animals were likely to be responsible for the local IgG and IgA responses, even though specific staining to characterise the immunoglobulin isotypes was not [9,21].…”
Section: Discussionsupporting
confidence: 52%
“…This has been described previously ( Stevenson et al 1994 ), but briefly naive lambs received either a single oral dose with 50 000 infective third stage larvae (L3) and were killed 21 days post infection, or were repeatedly infected (3000 L3 five times weekly for seven weeks), treated with Fenbendazole (5 mg/kg. ), challenged with 50 000 L3 and killed ten days later.…”
Section: Methodsmentioning
confidence: 99%
“…In agreement with these findings, the cellularity of the abomasal mucosa has also been observed to increase substantially in immune sheep subjected to L3 challenge: most of the cells that infiltrate the mucosa are T cells and eosinophils (25). Mast cells may also affect T. circumcincta at this site: worm burdens negatively correlate with levels of abomasal mast cell protease, released from activated mast cells (26), and numbers of globule leucocytes (14). The latter are thought to be degranulated mast cells (27).…”
Section: Immune Responses To Teladorsagia Circumcincta: Current Knowlmentioning
confidence: 99%