Mucosal immunity in a healthy gut

Brandtzæg, Per

doi:10.1533/9780857095749.1.34

Cited by 4 publications

(2 citation statements)

References 272 publications

(340 reference statements)

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“…Additionally, we evaluate whether BMI predicts the elevation of hsCRP in a nonoverweight group of breastfeeding women as previously reported for other populations. We focus on apparently healthy breastfeeding mothers because they are understudied despite their importance in the inter-generational dynamics (Kuzawa et al, 2013) and the developmental programming of health and disease (Brandtzaeg, 2013; Moore, 2013). Maternal inflammation can alter breastmilk constituents such as secretory immunoglobulin A (Groer et al, 2004) and adiponectin (Ozarda et al, 2012), through which nursing infants’ health and immune development will be affected.…”

Section: Introductionmentioning

confidence: 99%

Nutrient intakes associated with elevated serum C‐reactive protein concentrations in normal to underweight breastfeeding women in Northern Kenya

Fujita

Brindle

et al. 2014

American J Hum Biol

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Objectives Low-grade elevation of C-reactive protein (CRP) is a non-specific inflammatory marker, used as a predictor for cardiovascular disease development and chronic inflammatory risks. Research investigating dietary influences on inflammation has focused primarily on the relationship between dietary characteristics, CRP elevation and BMI in the populations at greatest risk for cardiovascular disease, namely those in the overweight and obese ranges, often in clinical settings and/or among those middle aged or older, leaving little information about normal to underweight populations of reproductive age in ecological settings. This study evaluates impacts of dietary nutrients on serum CRP levels in a population of predominantly underweight to normal weight adult women experiencing the additional nutritional demands of lactation. Methods Data from non-overweight breastfeeding Ariaal women of Kenya collected in 2006 were used (n = 194). Logistic regression models were applied using low-grade CRP elevation (hsCRP > 3 mg/L) as the outcome variable and dietary nutrients, age, BMI, and serum retinol as predictors. Results Models showed that energy intake (Kcal) and age were positive predictors of CRP elevation while folate intake, total vitamin A intake, and serum retinol concentration were protective against CRP elevation. Unlike previous studies among higher BMI populations, this study found no significant effect of dietary lipids/fatty acids or BMI on CRP elevation. Conclusions The effects of specific dietary nutrients on inflammatory status may vary with BMI or, in women, reproductive status. Further research should investigate the role of dietary fats, fatty acids, and antioxidant vitamins across populations with a wide range of BMI, including postpartum women.

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Section: Introductionmentioning

confidence: 99%

Nutrient intakes associated with elevated serum C‐reactive protein concentrations in normal to underweight breastfeeding women in Northern Kenya

Fujita

Brindle

et al. 2014

American J Hum Biol

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“…The recombinant protein (HAr) was previously produced in a protein-recombinant expression model [15] with advantages in terms of production costs, expression levels, as well as its possible use in the oral vaccination of animals [29]. Therefore, mucosal vaccination was demonstrated in an animal model (poultry) due to the importance of local mucosal immunity against diseases caused by respiratory viruses such as AI [44].…”

Section: Discussionmentioning

confidence: 99%

Immune Evaluation of Avian Influenza Virus HAr Protein Expressed in Dunaliella salina in the Mucosa of Chicken

et al. 2022

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Avian influenza (AI) is a serious threat to the poultry industry worldwide. Currently, vaccination efforts are based on inactivated, live attenuated, and recombinant vaccines, where the principal focus is on the type of virus hemagglutinin (HA), and the proposed use of recombinant proteins of AI virus (AIV). The use of antigens produced in microalgae is a novel strategy for the induction of an immune response in the mucosal tissue. The capacity of the immune system in poultry, particularly in mucosa, plays an important role in the defense against pathogens. This system depends on a complex relationship between specialized cells and soluble factors, which confer protection against pathogens. Primary lymphoid organs (PLO), as well as lymphocytic aggregates (LA) such as the Harderian gland (HG) and mucosa-associated lymphoid tissue (MALT), actively participate in a local immune response which is mainly secretory IgA (S-IgA). This study demonstrates the usefulness of subunit antigens for the induction of a local and systemic immune response in poultry via ocular application. These findings suggest that a complex protein such as HAr from AIV (H5N2) can successfully induce increased local production of S-IgA and a specific systemic immune response in chickens.

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Role of the Intestinal Immune System in Health

Brandtzæg

2017

Crohn's Disease and Ulcerative Colitis

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Mucosal immunity in a healthy gut

Cited by 4 publications

References 272 publications

Nutrient intakes associated with elevated serum C‐reactive protein concentrations in normal to underweight breastfeeding women in Northern Kenya

Nutrient intakes associated with elevated serum C‐reactive protein concentrations in normal to underweight breastfeeding women in Northern Kenya

Immune Evaluation of Avian Influenza Virus HAr Protein Expressed in Dunaliella salina in the Mucosa of Chicken

Role of the Intestinal Immune System in Health

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