Mucosal Immunity in Adult Primary Glomerulonephritis

Rostoker, Guy; Pech, M A; Petit-Phar, M; Benmaadi, A.; Cholin, S.; Lang, Philippe; Dubert, J M; Weil, B; Lagrue, G

doi:10.1159/000185808

Cited by 11 publications

(2 citation statements)

References 17 publications

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“…␤2M is a product of a variety of activated lymphoid cells. ␤2M has also been detected in human saliva, and significantly higher levels were found in saliva from patients with juvenile periodontitis (1), adult primary glomerulonephritis (28), and primary Sjögren's syndrome (20). There are no reports on ␤2M measurements in the saliva of HIV-infected individuals.…”

mentioning

confidence: 99%

Oral Fluids as an Alternative to Serum for Measurement of Markers of Immune Activation

Nishanian

Aziz²,

Chung³

et al. 1998

Clin Diagn Lab Immunol

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Oral fluids are convenient alternatives to blood sampling for evaluating significant metabolic components. Two forms of oral fluids, oral mucosal transudates (OMT) and saliva, were collected and compared for content of soluble products of immune activation. The data confirm that OMT and saliva represent distinct body fluids. The concentrations, outputs, and analyte/protein ratios of β-2-microglobulin (β2M), soluble tumor necrosis factor alpha receptor II (sTNFαRII), and neopterin were measured. Both the OMT and the saliva of most of the individuals in the control healthy populations had measurable levels of all three activation markers. When the immune system is activated, as in human immunodeficiency virus (HIV) infection, the levels of β2M and sTNFαRII are increased in both OMT and saliva compared to those in a healthy control population. OMT levels correlated better with levels in serum than did saliva and appear to reflect systemic immune activation in HIV infection. Because acquisition of oral fluids is noninvasive and easily repeatable, measurement of β2M and/or sTNFαRII content in OMT could be useful in the assessment of disease activity in patients with HIV infection or chronic inflammatory diseases.

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mentioning

confidence: 99%

Oral Fluids as an Alternative to Serum for Measurement of Markers of Immune Activation

Nishanian

Aziz²,

Chung³

et al. 1998

Clin Diagn Lab Immunol

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“…The fact that deposited IgA in the glomerular mesangium in IgAN is predominantly polymeric IgA1, which is usually derived mainly from the mucosal immune system, suggests that the pathogenesis of this disease is related to abnormality of mucosal immunity [10]. In fact, many studies have suggested the involvement of mucosa in the immunological abnormalities in IgAN [11–16]. In the mucosal immune system, a unique type of T cell bearing γδ TCR ( γδ T cell) is distributed more abundantly than are αβ TCR‐positive T cells ( αβ T cells), which are more common in peripheral blood and other lymphoid organs.…”

Section: Introductionmentioning

confidence: 99%

Oligoclonally expandingγδT lymphocytes induce IgA switching in IgA nephropathy

Toyabe

Harada

Uchiyama

2001

Clinical and Experimental Immunology

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SUMMARYThe aetiology of IgA nephropathy (IgAN) is closely related with abnormality of mucosal immunity. We investigated the roles of gd T cells in the regulation of IgA production by B cells in IgAN patients. The proportion of gd T cells in peripheral blood mononuclear cells (PBMNC) was higher in IgAN patients than in the controls and was found to be correlated with the proportion of surface IgA-positive (sIgA1) B cells, which are precursors of IgA-secreting plasma cells. After in vitro PWM stimulation, sIgA expression on B cells and IgA production were significantly enhanced in PBMNC obtained from IgAN patients, whereas the enhancements were abolished by removal of gd T cells from the PBMNC. Purified gd T cells from IgAN patients induced surface IgA expression on naõ Ève sIgD1 B cells more effectively than did ab T cells. Moreover, stimulated gd T cells from IgAN patients produced a larger amount of TGF-b 1, which is one of the main cytokines that induces IgA class switching on B cells, as compared with ab T cells and control gd T cells. The expanded gd T cells from IgAN patients exclusively expressed Vg9, and the nucleotide sequences of junctional regions of Vg9 showed very limited TCR diversities. It was therefore concluded that gd T cells, which are expanded in response to specific antigens, enhance IgA class switching on B cells in IgAN patients.

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Salivary SIgA and SIgA 1 in coeliac disease, inflammatory bowel disease and controls

1999

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Levels of secretory IgA1 (SIgA1) in the saliva have not been measured previously in either coeliac disease (CD) or inflammatory bowel disease (IBD). Saliva was collected from coeliacs, IBD patients and controls. The concentration of total SIgA in saliva was measured by enzyme linked immunosorbent assay (ELISA) with an anti-human SIgA antibody as the bound phase and human SIgA isolated from colostrum as the standard. The concentration of SIgA1 was determined using an ELISA with a lectin with a high affinity for human SIgA1. The IBD patients have a significantly higher concentration of SIgA1 than the controls. The rate of secretion of saliva and %SIgA1 was significantly lower in coeliacs than in the control and IBD groups. The rate of secretion of SIgA1 was significantly higher in the IBD than in the coeliacs. We describe hitherto unreported levels of SIgA1 in CD and IBD.

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Mucosal Immunity in Adult Primary Glomerulonephritis

Cited by 11 publications

References 17 publications

Oral Fluids as an Alternative to Serum for Measurement of Markers of Immune Activation

Oral Fluids as an Alternative to Serum for Measurement of Markers of Immune Activation

Oligoclonally expandingγδT lymphocytes induce IgA switching in IgA nephropathy

Salivary SIgA and SIgA 1 in coeliac disease, inflammatory bowel disease and controls

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