Mucosal Immunity in Fish

Salinas, Irene; Ding, Yang; Fernández-Montero, Álvaro; Sunyer, J. Oriol

doi:10.1007/978-3-030-85420-1_12

Cited by 14 publications

(6 citation statements)

References 323 publications

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“…Interestingly, teleost fish do not produce IgA like in mammals. However, they produce IgT or IgZ, which is functionally similar to mucosal immunoglobulins like IgA in mammals and is primarily associated with mucosal immune responses, particularly in the gut upon infection or vaccination (Castro et al, 2022;Dornburg et al, 2021;Salinas et al, 2021;Yu et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Comparative proteome analysis revealed potential biomarkers and the underlying immune mechanisms in Vibrio‐resistant hybrid grouper, Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂

Abu Aziz,

Christianus,

Wan Solahudin

et al. 2024

Journal of Fish Diseases

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Vibrio alginolyticus is the causative agent of vibriosis, a common bacterial infection in grouper aquaculture that is associated with the development of haemorrhagic and non‐haemorrhagic ulcerations on the fish. In the present study, comparative proteome analysis was performed on serum samples from Vibrio‐resistant and Vibrio‐susceptible grouper. Samples were analysed using high‐throughput LC‐MS/MS and identified 2770 unique peptides that corresponded to 344 proteins. Subsequent analysis identified 21 proteins that were significantly up‐regulated in the resistant group compared to the control and the susceptible groups. Those proteins are associated with immunostimulatory effects, signalling and binding cascade, metabolism, and maintaining tissue integrity and physiological condition. Besides, potential protein biomarkers related to the immune system were identified, which could be associated with the disease‐resistant phenotype. These data provide insights into the underlying immune mechanism of hybrid groupers upon Vibrio sp. infection.

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Section: Discussionmentioning

confidence: 99%

Comparative proteome analysis revealed potential biomarkers and the underlying immune mechanisms in Vibrio‐resistant hybrid grouper, Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂

Abu Aziz,

Christianus,

Wan Solahudin

et al. 2024

Journal of Fish Diseases

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“…However, in rainbow trout, CD4 and CD8 molecules are linked not only to T cells but also to other cells, including dendritic cells on intestinal mucosa ( 72 ) and monocytes/macrophages ( 73 ). Although not as well studied as their mammalian counterparts, CD4 + and CD8 + T cells and NK cells are believed to play an active role in mucosal immunity in fish ( 74 ). Innate immunity is known to instruct adaptive immunity of invading insults and how to deal with them, which results in a feedback loop regulating immune response ( 74 , 75 ).…”

Section: Discussionmentioning

confidence: 99%

Modulation of metabolic and immunoregulatory pathways in the gut transcriptome of Atlantic salmon (Salmo salar L.) after early nutritional programming during first feeding with plant-based diet

Tawfik,

Betancor,

McMillan

et al. 2024

Front. Immunol.

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IntroductionPlant-based nutritional programming is the concept of exposing fish at very early life stages to a plant-based diet for a short duration to improve physiological responses when exposed to a similar plant-rich diet at a later developmental stage. The mechanisms of action underlying nutritional programming have not been fully deciphered, and the responses may be controlled at multiple levels.MethodsThis 22-week study examines gut transcriptional changes after nutritional programming. Triplicate groups of Atlantic salmon were fed with a plant (V) vs. a marine-rich (M, control) diet for 2 weeks (stimulus phase) at the first exogenous feeding. Both stimulus fish groups (M and V fish) were then fed the M diet for 12 weeks (intermediate phase) and lastly fed the V diet (challenge phase) for 6 weeks, generating two dietary regimes (MMV and VMV) across phases. This study used a whole-transcriptome approach to analyse the effects of the V diet at the end of stimulus (short-term effects) and 22 weeks post-first feeding (long-term effects). After the stimulus, due to its developmental stage, the whole intestine was used, whereas, after the challenge, pyloric caeca and middle and distal intestines were examined.Results and discussionAt the stimulus end, genes with increased expression in V fish enriched pathways including regulatory epigenetic responses and lipid metabolism, and genes involved in innate immune response were downregulated. In the middle intestine at the end of the challenge, expression levels of genes of lipid, carbohydrate, and energy metabolism were increased in V fish, while M fish revealed increased expression of genes associated with autoimmune and acute adaptive immune response. The distal intestine of V fish showed increased expression of genes associated with immune response and potential immune tolerance. Conversely, the distal intestine of M fish at challenge revealed upregulation of lipid and carbohydrate metabolic pathways, tissue degeneration, and apoptotic responses. The present study demonstrated nutritional programming-associated changes in the intestinal transcriptome, with altered expression of genes involved in both immune responses and different metabolic processes. While there were limited changes in growth between the groups, the results show that there were transcriptional differences, suggesting a programming response, although the mechanism of this response still requires to be fully elucidated.

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“…Teleost fish also possess an adaptive immune system that relies on somatic recombination of germline-encoded VDJ fragments to produce a large number of antigen receptors expressed on T and B lymphocyte membranes ( 295 ). Studies have shown that teleost MALT has a large number of antigen-presenting cells in mucosal sites, including dendritic cells (DCs), macrophages, IgT/Z + B cells and granulocytes, all of which have been shown to have antigen uptake functions ( 296 – 298 ).…”

Section: Mechanism Of Aquatic Vaccinesmentioning

confidence: 99%

Current status and development prospects of aquatic vaccines

Liu

et al. 2022

Front. Immunol.

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Diseases are a significant impediment to aquaculture’s sustainable and healthy growth. The aquaculture industry is suffering significant financial losses as a result of the worsening water quality and increasing frequency of aquatic disease outbreaks caused by the expansion of aquaculture. Drug control, immunoprophylaxis, ecologically integrated control, etc. are the principal control strategies for fish infections. For a long time, the prevention and control of aquatic diseases have mainly relied on the use of various antibiotics and chemical drugs. However, long-term use of chemical inputs not only increases pathogenic bacteria resistance but also damages the fish and aquaculture environments, resulting in drug residues in aquatic products, severely impeding the development of the aquaculture industry. The development and use of aquatic vaccines are the safest and most effective ways to prevent aquatic animal diseases and preserve the health and sustainability of aquaculture. To give references for the development and implementation of aquatic vaccines, this study reviews the development history, types, inoculation techniques, mechanisms of action, development prospects, and challenges encountered with aquatic vaccines.

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Mucosal Immunity in Fish

Cited by 14 publications

References 323 publications

Comparative proteome analysis revealed potential biomarkers and the underlying immune mechanisms in Vibrio‐resistant hybrid grouper, Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂

Comparative proteome analysis revealed potential biomarkers and the underlying immune mechanisms in Vibrio‐resistant hybrid grouper, Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂

Modulation of metabolic and immunoregulatory pathways in the gut transcriptome of Atlantic salmon (Salmo salar L.) after early nutritional programming during first feeding with plant-based diet

Current status and development prospects of aquatic vaccines

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