Mucosal manifestations of pemphigus vulgaris in ear, nose, and throat; before and after treatment

Robati, Reza M.; Rahmati-Roodsari, Mohammad; Dabirmoghaddam, Peyman; Farnaghi, A; Mahboobi-rad, Farshid; Rahimi, Hamzeh; Toossi, Parviz

doi:10.1016/j.jaad.2011.06.022

Cited by 22 publications

(41 citation statements)

References 14 publications

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“…2 The regions most commonly involved are the oropharynx, larynx, nasal mucosa, and esophagus. [3][4][5][6][7] Although mucosal involvement is commonly seen in otolaryngological practice, the incidence is unknown. Nasal involvement manifests as obstruction, crusting, and epistaxis.…”

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confidence: 99%

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Evaluation of Olfaction in Patients with Pemphigus Vulgaris

Meriç

Doğan

Veyseller

et al. 2014

Am J Rhinol�Allergy

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confidence: 99%

“…8,9 Studies have shown that PV lesions can be either symptomatic or asymptomatic. [3][4][5][6][7] A literature search of English language publications revealed no studies regarding olfactory dysfunction associated with PV. The aim of this study was to evaluate olfactory function in PV patients compared with a healthy control group.…”

mentioning

confidence: 99%

Evaluation of Olfaction in Patients with Pemphigus Vulgaris

Meriç

Doğan

Veyseller

et al. 2014

Am J Rhinol�Allergy

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“…The other mucosal areas, nasal cavity, larynx (epiglottis, vocal cords), oropharynx, esophagus, vagina, vulva, penis, and anus may also be affected [1,13]. Epistaxis and hoarseness are present owing to the involvement of the nose, pharynx, and larynx [1,13,[35][36][37]. Genital mucosa is one of the frequent sites involved in PV after the oral mucosa [37].…”

Section: Clinical Featuresmentioning

confidence: 99%

Pemphigus: Subtypes, Clinical Features, Diagnosis, and Treatment

Kılıç¹

2018

Autoimmune Bullous Diseases

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Pemphigus is a group of autoimmune blistering disorders associated with autoantibodies against the keratinocyte cell surface. Pemphigus has three major variants: pemphigus vulgaris (PV), pemphigus foliaceus (PF), and paraneoplastic pemphigus (PNP) which all have further subtypes. The variants of pemphigus are classified depending upon the clinical and histological features, immunofluorescence staining pattern, and autoantibody profile of the disease. The onset and course of pemphigus appear on the basis of interaction between genetic predisposition and various triggering factors. Pemphigus vulgaris is the most commonly seen and representative clinical form of pemphigus. Together with clinical manifestations, the histopathological and immunopathological data support the diagnosis. As though some pemphigus variants, particularly pemphigus vulgaris and paraneoplastic pemphigus, have a mortality risk, early diagnosis is necessary and onset of treatment should be promptly initiated. In this chapter, firstly, classification of pemphigus is described. After then, clinical features, histopathological and immunopathological findings, target antigens, etiopathogenesis and comorbidities of each pemphigus variant are discussed briefly.Keywords: pemphigus, pemphigus variants, clinical manifestations, pathogenesis, histopathology, immunopathology IntroductionPemphigus is a distinct organ-specific autoimmune blistering disorder involving skin and mucous membranes associated with autoantibodies directed against desmosomes-intercellular adhesive molecule complex localized on the keratinocyte cell surface [1][2][3][4].© 2018 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Pemphigus has three major variants, which are classified depending on the basis of the clinical, histological features, immunofluorescence staining pattern and autoantibody profile of the disease including pemphigus vulgaris (PV), pemphigus foliaceus (PF), and paraneoplastic pemphigus (PNP), which all have further subtypes. Less frequently seen and newer variants of pemphigus include IgA pemphigus (IGAP) and pemphigus herpetiformis (PH) [1-6].The term "pemphigus" origins from the Greek word "pemphix", which has a meaning of "blister" [1]. It is a chronic potentially life-threating bullous disorder if not treated on time [4,7,8]. The phenotypes of pemphigus represent a complex spectrum with multiple genetic and environmental factors playing a role in disease pathogenesis [9,10].Together with clinical manifestations, the histopathological and immunopathological data support the diagnosis of the disease. The best site for the cutaneous biopsy for the appropriate histopathological examination is a fresh (< 24 h) small vesicle or 1/3 of the peripheral portion of the blister including the perilesional normal appearing s...

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“…Os locais mais acometidos são a "mucosa jugal", ventre da língua e gengiva. O envolvimento da pele e de outras mucosas são frequentemente relatados (1,5) . As lesões são bastante dolorosas, e os pacientes costumam relatar dificuldade na mastigação, fonação e deglutição (4) .…”

Section: Introductionunclassified

“…O tecido conjuntivo subjacente costuma apresentar infiltrado inflamatório crônico. O diagnóstico clí-nico deve ser confirmado com o exame histopatológico e, em alguns casos, complementado com a imunofluorescência (2)(3)(4)(5)(6)(7) . Exames sorológicos de imunofluorescência, principalmente a direta, podem ser utilizados para uma melhor confirmação diagnóstica.…”

Section: Introductionunclassified

Eficácia Do Uso De Corticosteroide Sistêmico No Tratamento Do Pênfigo Vulgar Oral

Ferreira

Lyra²,

Pereira³

et al. 2016

ACS

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Con lito de interesses:Não Contribuição dos autores: VYNF concepção, planejamento e elaboração do manuscrito. TCL concepção, planejamento e elaboração do manuscrito. LPL orientação e planejamento do manuscrito. MABN planejamento e obtenção de dados importantes para elaboração do manuscrito. LBS orientação e obtenção de dados importantes para elaboração do manuscrito. PRFB orientação, planejamento e revisão. Contato para correspondência: AbstractIntroduction: Pemphigus vulgaris is an autoimmune disease characterized by ulcerative and bullous lesions on skin and mucous membranes. The aim of this paper is to report a case of oral pemphigus vulgaris, emphasizing the treatment and discuss some clinical and histopathologic features of this disease. Case Report: The patient is a 38-year-old male, feodermic, who was referred to a specialized service in oral diagnosis in the city of João Pessoa -Paraíba State, complains of multiple ulcerative lesions in the oral cavity, dysphagia, dysphonia, and marked weight loss. The diagnostic hypotheses were pemphigus vulgaris and mucous membrane pemphigoid. An incisional biopsy was performed on buccal mucosa and the diagnosis of the pemphigus vulgaris was made. Initially, the treatment of choice was systemic administration of prednisone 80 mg. In the first weeks, a remission of the oral lesions occurred. The dosage was gradually reduced to the current dose of 2.5 mg/day. Conclusion: Treatment was effective, once there was remission of all oral lesions.

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Mucosal manifestations of pemphigus vulgaris in ear, nose, and throat; before and after treatment

Cited by 22 publications

References 14 publications

Evaluation of Olfaction in Patients with Pemphigus Vulgaris

Evaluation of Olfaction in Patients with Pemphigus Vulgaris

Pemphigus: Subtypes, Clinical Features, Diagnosis, and Treatment

Eficácia Do Uso De Corticosteroide Sistêmico No Tratamento Do Pênfigo Vulgar Oral

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