Mucous Gland Adenoma of the Lung: A Neoplastic Counterpart of Mucinous Bronchial Glands

Sasaki, Eiichi; Masago, Katsuhiro; Kogure, Yoshihito; Fujita, Shiro; Iwakoshi, Akari; Kuroda, Hiroaki; Tsuzuki, Toyonori; Tsuta, Koji; Matsushita, Hirokazu; Oki, Masahide

doi:10.1016/j.modpat.2023.100182

Cited by 9 publications

(5 citation statements)

References 28 publications

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“…NKX3.1 is an androgen-regulated tumor suppressor gene, that has been used as specific of prostatic origin; however, some breast carcinomas are also positive for this factor, 13,14 and some †The technique is not described in this article, but the authors cite this work as using a 50-gene panel in their subsequent work. salivary-type glands [15][16][17] ; we show that it is rarely expressed by PH tumor cells. CK14 is a high-molecular-weight basal cytokeratin shown to be useful in distinguishing breast papillary lesions, because it is generally positive in benign, but not in atypical or malignant lesions.…”

Section: Discussionmentioning

confidence: 68%

Immunohistochemical and Molecular Characteristics of Anogenital Papillary Hidradenomas

Karpathiou,

Sim,

Picot

et al. 2023

The American Journal of Dermatopathology

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Background: Papillary hidradenomas (PHs) of the anogenital region are uncommon tumors whose immunohistochemical and molecular profile have been infrequently studied. Material and methods: We studied 15 PHs by next-generation sequencing and 10 immunohistochemical markers (PAX8, GATA3, HER2, MSH6, PMS2, estrogen, progesterone and androgen receptors, CK14, and NKX3.1). Results: All cases expressed GATA3, whereas none expressed PAX8, and rare tumor cells were NKX3.1-positive. Almost all cases expressed estrogen receptors (ER), progesteron receptors (PR), and androgen receptors (AR). CK14 was expressed by myoepithelial cells, whereas only rarely by the epithelial tumor cells. HER2 showed no significant expression. Immunohistochemical expression for the mismatch repair proteins showed persistence in all cases. Molecular analysis often showed PIK3CA mutations, as well as KRAS, SMO, and MAP2K1 mutations. Conclusion: Anogenital PHs frequently harbor PIK3CA mutations and show a PAX8-, GATA3/ER/PR/AR + immunohistochemical profile.

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Section: Discussionmentioning

confidence: 68%

Immunohistochemical and Molecular Characteristics of Anogenital Papillary Hidradenomas

Karpathiou,

Sim,

Picot

et al. 2023

The American Journal of Dermatopathology

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“…One study found differences in mucin expression patterns between BA and IMA by elucidating the mucin core expression profile ( 43 ). HNF4a also is a useful marker for differentiation between BA and IMA; this marker is negative for BA but positive for IMA ( 44 ). In addition, mixed squamous cell and glandular papilloma is a rare benign tumor with similar morphology and cell composition to BA/CMPT, which can be distinguished by the anatomical site of the lesion ( 42 ), or the presence or absence of AKT1 mutations ( 45 ).…”

Section: Discussionmentioning

confidence: 99%

Multiple bronchiolar adenomas/ciliated muconodular papillary tumors of the bilateral lung with tumor budding and potential malignant transformation into squamous cell carcinoma: a case report and literature review

Sun¹,

Zhao²,

Zhang³

et al. 2023

Transl Lung Cancer Res

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Background Bronchiolar adenoma (BA)/ciliated muconodular papillary tumor (CMPT) is a rare lung tumor characterized by ciliated, mucous and basal cells. Recently, some cases of driver mutations or malignant transformations have been reported. However, the nature of BA/CMPT remains controversial. Here, we report a case of bilateral pulmonary multiple BAs with tumor budding and squamous metaplasia. Case Description A 55-year-old man presented with multiple small nodules in the lower lobes of the bilateral lungs on physical examination 7 years prior. During the past 3 years of regular follow-up, some nodules had slightly enlarged. Because the nodules were mostly solid, the patient underwent video-assisted thoracoscopic segmentectomy of the left lower lung. A postoperative pathological diagnosis of BA was made. In all lesions, the fusion and mutation of major driver genes were not detected by next-generation sequencing (NGS). No recurrence or metastasis was observed after 37 months of follow-up. Notably, all five resected lesions were BA/CMPT, and one lesion was accompanied by squamous metaplasia and tumor budding. Conclusions Our report found that BA/CMPT with squamous metaplasia and tumor budding has the potential to transform into lung squamous cell carcinoma, expanding its connection with malignant transformation. Smoking may be one of the risk factors. We also found that BA/CMPT can be multiple lesions rather than a solitary lesion.

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“…Currently, there are few studies on abnormal gene expression in MGA. Some researchers have found that NKX3.1 gene expression is signi cantly elevated in patients with MGA (23), and others have identi ed mutations in the GNAS gene (R201C) in these patients (20). Discovery of additional MGA-related gene mutations will facilitate a better understanding of their impact on development and treatment of disease, providing more possibilities for personalized medicine and precise treatment.…”

Section: Zaleski Et Al Observed Ve Different Growth Patterns In Mucin...mentioning

confidence: 99%

Bronchial mucous gland adenoma: a rare case report and literature review

Wan,

Ye,

Zeng

et al. 2024

Preprint

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Mucous gland adenoma (MGA) is a rare benign tumor originating from the tracheobronchial serous mucinous glands and ducts. Most cases of this tumor are central-type, with very few being peripheral-type. A PubMed search identified no more than five cases of peripheral-type MGA in the literature. This report describes a rare case of peripheral-type MGA and identifies some special pathological features. The patient underwent right lower lobectomy, and the lesion was completely removed by video-assisted thoracic surgery. Currently, a clear diagnosis of MGA cannot be made before surgery, and further cases must be accumulated for future clinical or basic research.

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Mucous Gland Adenoma of the Lung: A Neoplastic Counterpart of Mucinous Bronchial Glands

Cited by 9 publications

References 28 publications

Immunohistochemical and Molecular Characteristics of Anogenital Papillary Hidradenomas

Immunohistochemical and Molecular Characteristics of Anogenital Papillary Hidradenomas

Multiple bronchiolar adenomas/ciliated muconodular papillary tumors of the bilateral lung with tumor budding and potential malignant transformation into squamous cell carcinoma: a case report and literature review

Bronchial mucous gland adenoma: a rare case report and literature review

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