Mulberroside F Isolated from the Leaves of Morus alba Inhibits Melanin Biosynthesis.

Lee, Sangeun; Choi, Sang Yoon; Kim, Ho-Cheol; Hwang, Jae Sung; Lee, Byeong Gon; Gao, Jian; Kim, Sun Yeou

doi:10.1248/bpb.25.1045

Cited by 158 publications

(68 citation statements)

References 17 publications

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“…[48] Extracts of Mulberry (Morus alba) show superoxide scavenging activity which is involved in the protection against autooxidation. [74,75] The antioxidant activity of Basil, Oregano, and Thyme essential oils has been evaluated through various in vitro tests. [76] Thymus species exhibits their antioxidant activity through different mechanisms such as decomposition of peroxides, free radical scavenging, and prevention of continuous hydrogen abstraction.…”

Section: Plant Inhibitorsmentioning

confidence: 99%

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Garg

2017

IJGP

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Skin ageing is a complex multifactorial process occurring in all living beings. It generally comprises two independent and distinct processes, i.e., intrinsic, age-dependent or chronological aging and premature aging, or photoaging which is the result of undue exposure of the skin to ultraviolet (UV) radiations. Photoaging can be prevented or the effects of photoaging can be reduced by the use of certain anti-aging and anti-wrinkle agents. The extracellular matrix (ECM) which forms the outermost part of skin comprises fibroblasts and proteins such as collagen and elastin. Degradation of ECM is directly linked to skin aging and is responsible for the increase in activity of certain enzymes such as collagenase, elastase, and hyaluronidase (HYAL) that are involved in skin aging. With aging there is decrease in the levels of elastin, collagen, and hyaluronic acid which leads to loss of strength and flexibility of skin and appear as wrinkles on the skin. Further, the increase in the activity of collagenase, elastase, and HYAL is triggered by the high levels of reactive oxygen species produced when the skin is exposed to excessive UV radiations leading to skin aging. Today, in the age of modern science and advanced technology, although many techniques such as laser rejuvenation, plastic surgery, and lots of synthetic products such as sunscreen lotions, creams are available yet, there is a place for natural, herbal anti-aging cosmetics. Various botanical extracts have the power to reduce the appearance of skin aging and enhance the beauty of the skin. Medicinal plants have several phytoconstituents such as polyphenols, alkaloids, tannins, saponins, carotenoids, and terpenoids which possess antioxidant properties and can be used in treating the signs of aging. Some plants contain phenolic compounds which have free-radical scavenging property and can suppress aging. Some plants or their extracts possess several other constituents that may have the capability of inhibiting various enzyme such as HYAL, elastase, and matrix metalloproteinases enzyme that play a major role in skin aging. Some of them may possess the free radical scavenging or antioxidant property to fight against the signs of aging. This review focuses on the compilation of medicinal plants and natural compounds as anti-aging and anti-wrinkling agents along with their chemical constituents based on their possible molecular mechanism of action. The present review will facilitate the scientists working in this area for the development of new anti-aging and anti-wrinkle formulations with better efficiency and safety.

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Section: Plant Inhibitorsmentioning

confidence: 99%

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Garg

2017

IJGP

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“…Previous studies of Nerya et al [76] and Fu et al [77] showed that glabridin and isoliquiritigenin, the main ingredients of the hydrophobic fraction of licorice extract have been also shown to inhibit tyrosinase activity in B16 murine melanoma cells. Research also indicated that skin lightening potential of glabridin is found to be greater than that of hydroquinone, the artificial depigmentation agent widely used [76,78].…”

Section: Inhibition Of Tyrosinase Activitymentioning

confidence: 99%

Melanogenesis: Key Role of Bioactive Compounds in the Treatment of Hyperpigmentory Disorders

Ali¹,

Choudhary²,

Naaz³

et al. 2015

Pigmentary Disorders

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Skin pigmentation is an important human phenotypic trait that gives special aesthetic hue to individuals and also protective covering against solar ultra violet radiations, but excessive pigment production and uneven distribution, appear as serious undesirable hyperpigmentory anomalies. To overcome this, various therapeutic agents and skinlightening cosmetics are in big demand across Asia, and the quest for fairness has led to identification of many new ingredients. The mechanisms underlying pigmentation has been researched extensively and the knowledge are being updated regularly. To understand the etiology of normal and uneven skin pigmentation, first part of the review serves us basic updated information regarding the normal process of melanogenesis and strict coherent attributes that monitor the skin pigmentation control machinery. While the later part of the review focuses on some abnormal hyperpigmentory anomalies, their mode of action at the cellular level and various approaches that exploit the natural botanicals for their permanent and cost effective treatment.

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“…Mulberry extract: Several species of the Moraceae family exhibit antioxidant activity [32,33]. The focus here, though, will be on the skin-lightening activity of various parts of Morus (commonly known as mulberry) trees.…”

Section: Newer Topical Bleaching Formulationsmentioning

confidence: 99%

Melasma, Novel Treatment Modalities

Abdallah¹

2014

Pigmentary Disorders

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Treatment of melasma remains challenging due to frequent relapses and the occurrence of post-inflammatory hyperpigmentation (PIH) following many interventions. Treatment goals are inhibition of melanin synthesis and transfer by sunscreens, sun avoidance and the use of bleaching agents on one hand and removal of already present pigment by peeling, lasers and light on the other hand. Triple combination creams (TCC) (also known as Kligman's formula utilizing hydroquinone and modifications of Kligman's formula) remain the mainstay of treatment. Newer bleaching agents derived from plants and synthetic compounds have been introduced and many of them are promising safe substitutes for hydroquinone.Peeling agents especially superficial and medium depth peels are effective treatment modalities for melasma. Newer peeling agents are less irritating and may thus lead to fewer side effects. Q-switched lasers, which target melanin, have led to PIH until the innovation of "laser toning" and fractional Qswitched ruby, which have better outcomes. Fractional non-ablative and ablative lasers are useful at lower fluencies. Pulsed dye laser, which targets the vascular component in melasma, is promising with less melasma rebound.Combinations of the above-mentioned modalities usually have a better treatment outcome than either alone. This review will focus on the more recently introduced therapies.

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Mulberroside F Isolated from the Leaves of Morus alba Inhibits Melanin Biosynthesis.

Cited by 158 publications

References 17 publications

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Melanogenesis: Key Role of Bioactive Compounds in the Treatment of Hyperpigmentory Disorders

Melasma, Novel Treatment Modalities

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