Mulberry extract inhibits oleic acid‐induced lipid accumulation via reduction of lipogenesis and promotion of hepatic lipid clearance

Abstract

Our study suggests that the hypolipidemic effects of MWE occur via phosphorylation of AMPK and inhibition of lipid biosynthesis. Therefore, the mulberry extract may be active in the prevention of fatty liver.

Mulberry polyphenols induce cell cycle arrest of vascular smooth muscle cells by inducing NO production and activating AMPK and p53

“…Similarly, mulberry leaves have also shown promising biological effects (Jeszka-Skowron et al, 2014;Wu et al, 2013). Previous studies have shown the anti-hyperlipidemic, anticancer, liver-protecting, anti-inflammatory, and anti-obesity effects of mulberry water extracts (Hsu et al, 2012;Jeong, Jang, Kim, Kwon, & Kim, 2010;Ou et al, 2011Ou et al, , 2013Park, Lee, & Kim, 2013;Peng et al, 2011) as well as their ability to inhibit the development of atherosclerosis in cholesterol-fed rabbits (Chen et al, 2005). Because atherosclerosis and restenosis are complex and multifactorial processes, our aim was to identify the active polyphenols in mulberry polyphenol extracts (MPEs) and investigate the mechanisms underlying their inhibition of VSMCs proliferation and thereby atherosclerosis.…”

<i>Olea europaea</i> Linn (Oleaceae) Fruit Pulp Extract Suppresses Sterol Regulatory Element-Binding Proteins-1c via AMP-Activated Protein Kinase Activation in Human Hepatic Cells

“…Several natural products from plant origin have been suggested to be capable of preventing obesity via regulating hyperlipidemia and reducing adipose tissue mass, thus suppressing the occurrence of the metabolic, hepatic, and cardiovascular alterations associated with obesity [11][12][13]. Many studies have indicated that antioxidant phenolic compounds have been used in cellular and animal models for the treatment of obesity and hypolipidemic effects [14,15].…”

Therapeutic Impact of Berries (Morus Alba and Morus Rubra) Fruit Extract in the Regression of High-Fat Diet-Induced Cardiac Dysfunction in Rats

“…Group (4) is the HFD-treated rats for 1 12 consecutive . Groups (5) and (6) are obese rats treated for 6 weeks with 300 mg/kg body weight of ethanolic extract of white and purple berry (HFD/MA and HFD/MR, respectively). Group (7) is the obese rats treated for 6 weeks with antiobesity standard drug OR (12 mg/kg body weight) (HFD/OR).…”

“…The mulberry fruits (Morus alba L. [MA] and Morus rubra [MR]) distributed widely in Asia as a food containing potential health benefits beyond the traditional nutrients they provide [6]. It is rich in polyphenolic compounds including rutin, quercetin, and 1-deoxynojirimycin (DNJ).…”

“…It is rich in polyphenolic compounds including rutin, quercetin, and 1-deoxynojirimycin (DNJ). Hence, it has been medicated several diseases including dyslipidemia [7], diabetes [8], fatty liver [6], and hypertension diseases [8]. Besides, the mulberry fruits induce enzymatic antioxidant in diabetic models [8].…”