Mulberry fruit ameliorates Parkinson's-disease-related pathology by reducing α-synuclein and ubiquitin levels in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model

Gu, Pil Sung; Moon, Minho; Choi, Jin Gyu; Oh, Myung Sook

doi:10.1016/j.jnutbio.2016.08.014

Cited by 30 publications

(24 citation statements)

References 37 publications

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“…In mouse model of early PD, an extract of mulberry fruits, rich in phenolic contents (i.e., flavonoids, anthocyanins, and arotenoids), downregulated the expression of components such as α-SNCA and ubiquitin, also reduced neuronal toxicity; representing that the neuroprotective effect of this plant might be partially mediated by inhibition of the LBs formation in the brain. LBs is thought to trigger dopaminergic neurodegeneration in PD (Gu et al, 2017) (Figure 4).…”

Section: Polyphenols Ubiquitin-proteasome and Neurodegenerative Dismentioning

confidence: 99%

Targeting Ubiquitin-Proteasome Pathway by Natural Products: Novel Therapeutic Strategy for Treatment of Neurodegenerative Diseases

et al. 2020

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Polyphenols can act as proteasome-inhibitors or may modulate the proteasome activity, thereby improving neurodegenerative disorders by means of accumulation of ubiquitinated proteins, suppression of neuronal apoptosis, reduction of neurotoxicity, and improvement of synaptic plasticity and transmission. HIGHLIGHTS • Aberrant accumulation of intracellular ubiquitin-positive inclusions associated to neurodegenerative disorders. • Polyphenols, can act as proteasome-inhibitors or may modulate the proteasome activity. • Polyphenols can manage neurodegenerative impairments by targeting the ubiquitin-proteasome system (UPS). • Polyphenols exert UPS inhibitory activity, resulting in the accumulation of ubiquitinated proteins, suppression of neuronal apoptosis, reduction of neurotoxicity, and improvement of synaptic plasticity and transmission.

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Section: Polyphenols Ubiquitin-proteasome and Neurodegenerative Dismentioning

confidence: 99%

Targeting Ubiquitin-Proteasome Pathway by Natural Products: Novel Therapeutic Strategy for Treatment of Neurodegenerative Diseases

et al. 2020

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“…This observation correlated with decreases in pro-apoptotic protein expression and significant improvements in Parkinsonian symptoms. Additionally, a more recent study in the same model further reported that treatment with mulberry extract also significantly attenuated increases in expression of both alpha-synuclein and ubiquitin, the primary constituents of Lewy bodies, caused by MPTP treatment [123]. A similar effect was described in another chemical model of Parkinson’s disease using rats injected with 6-OHDA.…”

Section: The Use Of Anthocyanins As Novel Neuroprotective and Thermentioning

confidence: 72%

Anthocyanins and Their Metabolites as Therapeutic Agents for Neurodegenerative Disease

2019

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Neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS), are characterized by the death of neurons within specific regions of the brain or spinal cord. While the etiology of many neurodegenerative diseases remains elusive, several factors are thought to contribute to the neurodegenerative process, such as oxidative and nitrosative stress, excitotoxicity, endoplasmic reticulum stress, protein aggregation, and neuroinflammation. These processes culminate in the death of vulnerable neuronal populations, which manifests symptomatically as cognitive and/or motor impairments. Until recently, most treatments for these disorders have targeted single aspects of disease pathology; however, this strategy has proved largely ineffective, and focus has now turned towards therapeutics which target multiple aspects underlying neurodegeneration. Anthocyanins are unique flavonoid compounds that have been shown to modulate several of the factors contributing to neuronal death, and interest in their use as therapeutics for neurodegeneration has grown in recent years. Additionally, due to observations that the bioavailability of anthocyanins is low relative to that of their metabolites, it has been proposed that anthocyanin metabolites may play a significant part in mediating the beneficial effects of an anthocyanin-rich diet. Thus, in this review, we will explore the evidence evaluating the neuroprotective and therapeutic potential of anthocyanins and their common metabolites for treating neurodegenerative diseases.

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“…Indicating that mulberry extracts didn't fully protect brain tissue from injury induced by lead; they only prevent focal hemorrhage induced by lead. The extracts of mulberry fruits were reported to protect brain cells (PC12) when it was in direct contact in vitro [19] and ameliorates Parkinson's-disease-related pathology [54,55]. The cyanidin-3-O-β-dglucopyranoside isolated from mulberry fruits showed neuroprotective effects against cerebral ischemia [20].…”

Section: Brainmentioning

confidence: 99%

In vitro and In vivo Studies on Mulberry Extracts: Evaluation of Chemical and Anticancer Activities and Attenuation of Lead Toxicity

Ramis

Hammoud

Elsawy

2018

AJRB

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Lead (Pb) is one of the environmental pollutants. There has been a serious concern in the recent past regarding natural source for protection or curing from lead. The aim of the present study is evaluation and comparing of mulberry leaves and fruits extracts in protection from lead toxicity on the brain and testes of rats, as well as determination of their chemical activity and anticancer effect on hepatocarcinoma (HEPG2) and colon cancer cell line (HTC). Leaves extract showed higher results than fruits extract in total phenols, total flavonoids and antioxidant activities in both radical scavenging activity (DPPH) and ferric reducing power tests (FRAP). Leaves and fruits extracts exerts almost have the same killing effect on (HEPG2). Leaves extract has slight better killing power on (HTC) than fruits extract. In the experiment on rats; leaves showed more efficiency in a time dependent manner in ameliorating the harmful effect of lead on blood parameter like white and red blood cells, hemoglobin, cholesterol, triglycerides and glucose. Both leaves and fruits extracts have protective effect from injury induced by lead on tissues of rat testes, however, they showed little protective effect on brain tissue. In conclusion, mulberry leaves and fruits have considerable active compounds and antioxidant properties which are useful as anticancer agents. Moreover they showed protective effect against lead toxicity which induced anemia, metabolic disorder and tissue injury.

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Mulberry fruit ameliorates Parkinson's-disease-related pathology by reducing α-synuclein and ubiquitin levels in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model

Cited by 30 publications

References 37 publications

Targeting Ubiquitin-Proteasome Pathway by Natural Products: Novel Therapeutic Strategy for Treatment of Neurodegenerative Diseases

Targeting Ubiquitin-Proteasome Pathway by Natural Products: Novel Therapeutic Strategy for Treatment of Neurodegenerative Diseases

Anthocyanins and Their Metabolites as Therapeutic Agents for Neurodegenerative Disease

In vitro and In vivo Studies on Mulberry Extracts: Evaluation of Chemical and Anticancer Activities and Attenuation of Lead Toxicity

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