Mulberry Fruit Extract Ameliorates Adipogenesis<i>via</i>Increasing AMPK Activity and Downregulating MicroRNA-21/143 in 3T3-L1 Adipocytes

Lee, Mak-Soon; Kim, Yangha

doi:10.1089/jmf.2019.4654

Cited by 23 publications

(12 citation statements)

References 39 publications

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“…In contrast, dMF had little impact on TC and LDL. These observations generally reflect mouse studies using statins and mulberry extracts that reduce obesity, 28 , 29 , 30 , 31 , 32 , 33 diabetes 34 , 35 , 36 , 37 , 38 and hyperlipidemia 21 , 30 , 39 …”

Section: Discussionsupporting

confidence: 55%

Dried mulberry fruit ameliorates cardiovascular and liver histopathological changes in high-fat diet-induced hyperlipidemic mice

Chaiwong

Chatturong

Chanasong

et al. 2021

Journal of Traditional and Complementary Medicine

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Background and aim Metabolic disease encompasses most contemporary non-communicable diseases, especially cardiovascular and fatty liver disease. Mulberry fruits of Morus alba L. are a favoured food and a traditional medicine. While they are anti-atherosclerotic and reduce hyperlipidemic risk factors, studies need wider scope that include ameliorating cardiovascular and liver pathologies if they are to become clinically effective treatments. Therefore, the present study sought to show that freshly dried mulberry fruits (dMF) might counteract the metabolic/cardiovascular pathologies in mice made hyperlipidemic by high-fat diet (HF). Experimental procedure C57BL/6J mice were fed for 3 months with either: i) control diet, ii) HF, iii) HF+100 mg/kg dMF, or iv) HF+300 mg/kg dMF. Body weight gain, food intake, visceral fat accumulation, fasting blood glucose, plasma lipids, and aortic, heart, and liver histopathologies were evaluated. Adipocyte lipid accumulation, autophagy, and bile acid binding were also investigated. Results and conclusion HF increased food intake, body weight, visceral fat, plasma total cholesterol (TC) and low-density lipoprotein (LDL), TC/HDL ratio, blood glucose, aortic collagen, arterial and cardiac wall thickness, and liver lipid. Both dMF doses prevented hyperphagia, body weight gain, and visceral fat accumulation, lowered blood glucose, plasma TG and unfavourable TC/HDL and elevated plasma HDL beyond baseline. Arterial and cardiac wall hypertrophy, aortic collagen fibre accumulation and liver lipid deposition ameliorated in dMF-fed mice. Clinical trials on dMF are worthwhile but outcomes should be holistic commensurate with the constellation of disease risks. Here, dMF should supplement the switch to nutrient-rich from current energy-dense diets that are progressively crippling national health systems.

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Section: Discussionsupporting

confidence: 55%

Dried mulberry fruit ameliorates cardiovascular and liver histopathological changes in high-fat diet-induced hyperlipidemic mice

Chaiwong

Chatturong

Chanasong

et al. 2021

Journal of Traditional and Complementary Medicine

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“…In humans, MIR21 gene is located in the q23.1 region of chromosome 17, immediately downstream of the vacuole membrane protein-1 (VMP1) gene and resides within exon 10 of the VMP1 gene (Ribas et al, 2012). Various transcription factors may be involved in the regulation of miR-21 expression, including activator protein 1 (AP-1), Ets/PU.1, CCAAT/enhancer-binding protein α (C/EBPα), nuclear factor I (NF-I), serum response factor (SRF), p53, and STAT3 (Misawa et al, 2010;Luo et al, 2014;McClure et al, 2014;Collins and Hess, 2016;Lee and Kim, 2020). However, different transcription factors have different regulatory signaling pathways for miR-21 expression.…”

Section: Production and Regulation Of Expression Of Mir-21mentioning

confidence: 99%

MicroRNA-21 Is a Versatile Regulator and Potential Treatment Target in Central Nervous System Disorders

Bai

Bian

2022

Front. Mol. Neurosci.

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MicroRNAs (miRNAs) are a class of endogenous, non-coding, single-stranded RNAs with a length of approximately 22 nucleotides that are found in eukaryotes. miRNAs are involved in the regulation of cell differentiation, proliferation, invasion, apoptosis, and metabolism by regulating the expression of their target genes. Emerging studies have suggested that various miRNAs play key roles in the pathogenesis of central nervous system (CNS) disorders and may be viable therapeutic targets. In particular, miR-21 has prominently emerged as a focus of increasing research on the mechanisms of its involvement in CNS disorders. Herein, we reviewed recent studies on the critical roles of miR-21, including its dysregulated expression and target genes, in the regulation of pathophysiological processes of CNS disorders, with a special focus on apoptosis and inflammation. Collectively, miR-21 is a versatile regulator in the progression of CNS disorders and could be a promising biomarker and therapeutic target for these diseases. An in-depth understanding of the mechanisms by which miR-21 affects the pathogenesis of CNS disorders could pave the way for miR-21 to serve as a therapeutic target for these conditions.

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“…These effects were achieved by regulating the expression of mRNA involved in de novo cholesterol biosynthesis, cholesterol efflux, bile acid synthesis and HDL-C formation [110]. In 3T3-L1 cells, incubation with mulberry fruit extract could activate AMPK and inhibit adipogenesis genes, leading to the decrease of intercellular lipid accumulation and TG content [111].…”

Section: Mori Fructus (Sangshen)mentioning

confidence: 99%

Medicinal and edible plants in the treatment of dyslipidemia: advances and prospects

Chen

et al. 2022

Chin Med

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Dyslipidemia is an independent risk factor of cardiovascular diseases (CVDs), which lead to the high mortality, disability, and medical expenses in the worldwide. Based on the previous researches, the improvement of dyslipidemia could efficiently prevent the occurrence and progress of cardiovascular diseases. Medicinal and edible plants (MEPs) are the characteristics of Chinese medicine, and could be employed for the disease treatment and health care mostly due to their homology of medicine and food. Compared to the lipid-lowering drugs with many adverse effects, such as rhabdomyolysis and impaired liver function, MEPs exhibit the great potential in the treatment of dyslipidemia with high efficiency, good tolerance and commercial value. In this review, we would like to introduce 20 kinds of MEPs with lipid-lowering effect in the following aspects, including the source, function, active component, target and underlying mechanism, which may provide inspiration for the development of new prescription, functional food and complementary therapy for dyslipidemia.

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Mulberry Fruit Extract Ameliorates AdipogenesisviaIncreasing AMPK Activity and Downregulating MicroRNA-21/143 in 3T3-L1 Adipocytes

Cited by 23 publications

References 39 publications

Dried mulberry fruit ameliorates cardiovascular and liver histopathological changes in high-fat diet-induced hyperlipidemic mice

Dried mulberry fruit ameliorates cardiovascular and liver histopathological changes in high-fat diet-induced hyperlipidemic mice

MicroRNA-21 Is a Versatile Regulator and Potential Treatment Target in Central Nervous System Disorders

Medicinal and edible plants in the treatment of dyslipidemia: advances and prospects

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