Mulberry Leaf Polyphenols and Fiber Induce Synergistic Antiobesity and Display a Modulation Effect on Gut Microbiota and Metabolites

Abstract

The antiobesity molecular mechanisms of mulberry leave components were analyzed based on intestinal micro-ecology and metabolomics. An obesity model was established by feeding rats with a high-calorie diet. Rats were divided into seven groups: the obesity model control (MC), positive control (PC), mulberry leaf powder (MLP), mulberry leaf fiber (MLF), mulberry leaf polyphenols (MLPS), mulberry leaf fiber and polyphenols mixture (MLM), and normal control (NC), and fed daily for 6 consecutive weeks. The results demonstrated that the MLM group had the best efficiency on weight loss, indicating synergistic interactions between MLPS and MLF. The reduction of Firmicutes abundance, and the downstream Clostridiales, Lachnespiraceae, was a key pathway for the antiobesity effects. The increased abundances of Lactobacillus vaginalis and Lactobacillus gasseri might result in lipid metabolism disorder. The test groups regulated the amino acid and oligopeptides metabolic disorder tents to normal levels compared with the MC and NC groups.

Mulberry Leaf Flavonoids Improve Milk Production, Antioxidant, and Metabolic Status of Water Buffaloes

“…Even the mulberry leaf powder or their extracts have shown antioxidant, antiinflammatory, hypolipidemic, and neuroprotective properties (9,46,47). A substantial decrease in MDA levels in treated groups revealed that MLF possess practical potential to decrease lipid peroxidation, as reported previously in mice model (18,48).…”

Traditional Chinese Medicine Formula Kang Shuai Lao Pian Improves Obesity, Gut Dysbiosis, and Fecal Metabolic Disorders in High-Fat Diet-Fed Mice

“…Gut microbiota affects host metabolism by ways of transformation, absorption, and metabolism of exogenous substances (Li et al, 2019). It is rational that the alternation of metabolites reflects the changes of gut microbiota profiles.…”

Correlations between Microbiota Bioactivity and Bioavailability of Functional Compounds: A Mini-Review

“…A recent study showed that the presence of fibers increased the efficiency of polyphenolic extract from mulberry leaf, and the polyphenol-fiber mixture influences the gut microbiota (Table 1). Their synergistic effect resulted in the reduction of Firmicutes abundance, the downstream of Clostridiales and Lachnospiraceae, and a high concentration of butyrate [89]. The effects of synergic polyphenols and dietary fibers has also been described by a study on gastrointestinal digestion of two grape pomace extracts (GPEs) [90].…”