Müllerian inhibiting substance as a novel biomarker of cisplatin-induced ovarian damage

Yeh, John; Kim, Beomsu; Liang, Yuan; Peresie, Jennifer

doi:10.1016/j.bbrc.2006.06.195

Cited by 45 publications

(39 citation statements)

References 35 publications

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“…This protocol has been used previously by our laboratory and has been demonstrated to adversely affect the ovarian function of female rats. 6,22 The animals were given one IP injection of saline or cisplatin (4.5 mg/kg) once a week for two weeks. Ten milliliters (mls) of sterile 0.9% NaCl was administered subcutaneous (SQ) once a week over multiple injection sites and additionally as needed to prevent dehydration.…”

Section: Experiments 1: Cisplatin Reproductive Toxicitymentioning

confidence: 99%

“…In rats, cisplatin has previously been shown to cause damage to the ovaries by increasing the percentage of follicular apoptosis and follicular cyst formation in rats. 6,7 In animal models, several studies have been performed on the effects of cisplatin administration during pregnancy. Administration of cisplatin during pregnancy in mice and rats resulted in fetal mitochondrial toxicity, DNA adduct formation, and increased incidence of tumors of kidney, skin, lung and other organs.…”

Section: Introductionmentioning

confidence: 99%

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Reproductive Toxic Effects of Cisplatin and Its Modulation by the Antioxidant Sodium 2-Mercaptoethanesulfonate (Mesna) in Female Rats

Yeh¹,

Kim²,

Peresie³

2011

Reproductive Biology Insights

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Study Objective: Chemical protection against cisplatin, which is a commonly used cancer chemotherapeutic agent, is not well defined. We tested the hypothesis that the antioxidant mesna might protect against the cisplatin-induced repoductive effects in female rats. Design & Setting: Adult female rats were injected with saline, cisplatin alone, or mesna + cisplatin, mated with males, and euthanized on gestational day 17. Patients: Animal Model. Interventions: The administration of either cisplatin or mesna + cisplatin (two injections one week apart, mesna 30 minute pretreatment) followed by mating one week after treatment. Main Outcomes Measured:The number corpora lutea, implantation and resorptions sites, viable and non-viable fetuses, fetal weights, and the level of progesterone per corpus luteum. Results: The administration of cisplatin caused an increase in pre-and post-implantation loss, an increase in the number of resorptions and a decrease in the number of viable fetuses. Mesna administered prior to cisplatin resulted in a decrease in the rate of the pre-and post implantation loss, along with a decrease in the number of resorptions and an increase in the number of live fetuses. Conclusions: Prior exposure to cisplatin caused significant adverse effects on fertility as evidenced by the decreased implantation due to increased fetal loss. The administration of mesna appeared to temper cisplatin damage by lessening the cisplatin effects on fetal resorption.

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Section: Experiments 1: Cisplatin Reproductive Toxicitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Reproductive Toxic Effects of Cisplatin and Its Modulation by the Antioxidant Sodium 2-Mercaptoethanesulfonate (Mesna) in Female Rats

Yeh¹,

Kim²,

Peresie³

2011

Reproductive Biology Insights

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“…It was reported that chemotherapeutic medicines leading to either temporary or permanent infertility severely affected the ovaries and hormonal balance (DeVita et al 2005). In rats, CDDP has been shown to cause ovarian damage, at varying degrees ranging from minimal effects to ovarian failure, increased follicular apoptosis, decreased expression anti-Müllerian hormone (AMH), alterations in the estrous cycle, and a decrease in the number of AMH-producing follicles (Borovskaya et al 2004;Yucebilgin et al 2004;Yeh et al 2006Yeh et al , 2008. Our study has demonstrated that CDDP caused significant toxicity in the ovarian tissues of rats.…”

Section: Discussionmentioning

confidence: 69%

“…They claimed that addition of Leuprorelin acetate protected primordial follicles from harmful effect of CDDP. Yeh et al (2006) utilized the antioxidant sodium-2-mercaptoethanesulfonate (mesna) to preserve ovaries from CDDP induced toxic effect in rat model. It was found that the administration of mesna during low-dose CDDP treatment protected the ovaries by decreasing the loss of growing follicles in the ovaries (Yeh et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of bilberry (Vaccinium myrtillus L.) on cisplatin induced ovarian damage in rat

Pandır

Kara

2013

Cytotechnology

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Cisplatin is one of the most effective chemotherapeutic agents but injury may occur at higher doses. The aim of this study was to investigate the effect of bilberry on cisplatin induced toxic effects in rat ovary. Twenty-one female Wistar-Albino rats were utilized to form three groups: In group 1 (control group), each rat received intraperitoneal injection of 1 mL of 0.9 % NaCl saline solution during 10

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“…Our results were also in line with these findings as revealed by the impaired integrity of the surrounding granulosa layer in most of the follicles examined and significantly reduced number of primordial cells in cisplatin alone treated rats. Of course the damaging effects of cisplatin on ovarian follicles have been previously reported [49,50]. Yucebilgin et al [1] reported a significantly damage primordial follicles in rats after a single dose of cisplatin (5 mg/kg) and paclitaxel (7.5 mg/kg) [1].…”

Section: The Morphological Effectsmentioning

confidence: 99%

Cisplatin-Induced Ovarian Cytotoxicity and the Modulating Role of Aqueous Zest Extract of Citrus limonium (AZECL) in Rat Models

Gg¹,

Oa²,

Uk³

et al. 2017

J Tradi Med Clin Natur

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Cisplatin is a prominent member of the effective broad-spectrum antitumor drugs. However, its clinical usage is restricted due to some adverse side effects, such as testiculototoxicity, hepatotoxicity and nephrotoxicity. The aim of this study is to evaluate the effect of Aqueous Zest Extract of Citrus limonium (AZECL) on the ovary of female Wistar rat treated with Cisplatin. Twenty adult female Wistar rats were divided into four groups (A-D) containing five rats each. Group A rats served as negative control and were treated orally with 2.5 ml/kg body weight of normal saline, group B rats served as positive control group and were treated intraperitoneally with a single dose of 10 mg/kg body weight of Cisplatin, group C rats were treated orally with 50 mg/kg body weight of AZECL and group D rats were treated intraperitoneally with a single dose of 10 mg/kg body weight of Cisplatin and two weeks later treated orally with 50 mg/kg body weight of AZECL. Result showed a significant (p<0.01) decrease in primary follicles, secondary follicles, graafian follicles and a significant (p<0.01) increase in atretic follicles, PAS positive reaction and reduction in the total carbohydrate contents of the stromal cells in the positive control group. Also there was a significant (p<0.05) decrease in the activity level of FSH, LH and a significant (p<0.05) increase in Malondialdehyde when compared to rats in group A and C. The group post-treated with the extract had remarkable normalization of the histo-morphometric, histochemical and biochemical parameters when compared to the positive control group. Aqueous zests extract of C. limonium has a curative effect on cisplatin-induced cytotoxicity on the ovary.

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Müllerian inhibiting substance as a novel biomarker of cisplatin-induced ovarian damage

Cited by 45 publications

References 35 publications

Reproductive Toxic Effects of Cisplatin and Its Modulation by the Antioxidant Sodium 2-Mercaptoethanesulfonate (Mesna) in Female Rats

Reproductive Toxic Effects of Cisplatin and Its Modulation by the Antioxidant Sodium 2-Mercaptoethanesulfonate (Mesna) in Female Rats

Protective effect of bilberry (Vaccinium myrtillus L.) on cisplatin induced ovarian damage in rat

Cisplatin-Induced Ovarian Cytotoxicity and the Modulating Role of Aqueous Zest Extract of Citrus limonium (AZECL) in Rat Models

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