Multi‐Branched Plasmonic Gold Nanoechinus‐Based Triple Modal Bioimaging: An Efficient NIR‐to‐NIR Up and Down‐Conversion Emission and Photoacoustic Imaging

Abstract

It is demonstrated for the first time that plasmonic gold nanoechinus can act as a triple modal bio imaging agent such as upconversion luminescence, NIR fluorescence, and photoacoustic contrast agent upon various NIR excitation sources.

Multifunctional CuO/Cu2O Truncated Nanocubes as Trimodal Image-Guided Near-Infrared-III Photothermal Agents to Combat Multi-Drug-Resistant Lung Carcinoma

“…18,19 Previously, we have reported the utilization of gold nanoechinus (Au NEs) with ultrahigh molar extinction coefficients (∼10 12 M −1 cm −1 ) as a bioimaging probe in the NIR-II BW (980 nm). 45 CuO/Cu 2 O TNCs showed ∼4.5and 4.2-fold higher fluorescence intensities as compared to the PBS-injected control mice (Figure S14). Due to their ultrahigh molar extinction coefficients in the NIR We have evaluated the biodistribution of anti-EGFR-CuO/ Cu 2 O TNCs at 12 and 24 h postintravenous injection in H69AR tumor-bearing mice using inductively coupled mass spectrometry (ICP-MS) analysis.…”

“…In recent times, many nanomaterials were shown to have superior light-absorbing capabilities in the NIR region. Despite having low molar extinction coefficients in the NIR region (∼10 6 M –1 cm –1 ), SWCNTs were used as NIR-I (808 nm) to NIR-II (1000–1800 nm) fluorescence imaging probes for the visualization of tumors. , The fluorescence quantum yield of SWCNTs is quite low, only ∼0.004. , Previously, we have reported the utilization of gold nanoechinus (Au NEs) with ultrahigh molar extinction coefficients (∼10 12 M –1 cm –1 ) as a bioimaging probe in the NIR-II BW (980 nm) . In the current work, plasmonic CuO/Cu 2 O TNCs possess broad optical absorption with higher molar extinction coefficients (∼10 12 M –1 cm –1 ) in NIR-I, -II, and -III BWs.…”

Engineering Plasmonic Nanoparticles for Enhanced Photoacoustic Imaging

“…Using proven and standard imaging techniques like magnetic resonance imaging (MRI) and ultrasound, multimodal contrast agents can independently validate the PA response. ,, This is particularly helpful, since there is no clinically approved photoacoustic imaging system on the market yet. One such triple modal contrast agent was reported by Vijayaraghvan et al in 2016 . Here, they synthesized plasmonic gold nanoechinus and used them as upconverting, fluorescent, and photoacoustic contrast agents operating in the NIR-II range.…”

“…Broadening the absorbance of gold nanoparticles into the NIR-II range via shape control, gold nanoechinus 92 or with coatings, or polydopamine blackbody 36 have been reported. As described earlier, plasmonic coupling of nanoparticles due to self-assembly or aggregation can also red-shift its absorbance spectra.…”

Semiconducting polymer nanoparticles for multimodal biophotonics

“…Imaging agents administered in vivo are required complete clearance from living bodies for clinical translation according to guidelines of US Food and Drug Administration (FDA). [255][256] However, only a limited number of contrast agents have been reported to emit NIR-II PA signals, [195][196][257][258][259][260][261] and the majority of them (e.g. gold nanostructures, silver Chapter 4…”