Multi-central Clinical Research into Treating 80 Cases of Chronic Thrombocytopenia with Qi-supplementing and Yin-nourishing Therapy and Western Medicine

Zhou, Yuhong; Wei, Keming; He, Lv-yuan; Sun, Xin; Shao, Keding; Fang, Bingmu; Shen, Yueqian; Ye, Baodong; Shen, Jian‐Yong; Shen, Lin; Zhilu, Chen; Cai, Gang-li; Chen, Jian; Gao, Yaowen; Wang, Xiaoqiu; Zhu, Jiajia

doi:10.1016/s0254-6272(12)60004-1

Cited by 8 publications

(4 citation statements)

References 2 publications

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“…A clinical investigation concluded that most patients with ITP have a deficiency of qi or an impaired ability of the spleen to protect against hemorrhage; in addition, qisupplementing and yin-nourishing therapies were found to improve the TCM syndromes, including lassitude, dizziness, and palpitations (8,21). The JPYQSX formula is traditionally used to treat primary ITP in the clinical practice of TCM (22).…”

Section: Discussionmentioning

confidence: 99%

Jianpi Yiqi Shexue ameliorates immune thrombocytopenia related fatigue by regulating mitochondrial function

Zhang¹,

Jia²,

Gao³

et al. 2021

Ann Palliat Med

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Background: Immune thrombocytopenia (ITP) is a heterogeneous autoimmune disease characterized by platelet destruction. In previous studies, Jianpi Yiqi Shexue (JPYQSX) was shown to increase the peripheral platelet (PLT) counts in patients with ITP. In addition, JPYQSX also dramatically alleviated weakness and fatigue. This study aimed to investigate the effect of JPYQSX on ITP related fatigue and to illuminate the underlying mechanisms of its therapeutic effects. Methods: Prednisone and different doses of JPYQSX were orally administered to mice with ITP. Posttreatment, all mice were subjected to a forced swimming test. In addition, blood samples were analyzed using an automated hematology analyzer. Spleen, liver, lungs, heart, kidneys, and colon tissues were collected to determine the expressions of reactive oxygen species (ROS), adenosine triphosphate (ATP), mitochondrial DNA (mtDNA), succinate dehydrogenase complex flavoprotein subunit A (SDHA), caseinolytic mitochondrial matrix peptidase proteolytic subunit (ClpP), and Lon peptidase 1 (Lonp1). Results: Compared with the vehicle group, JPYQSX prolonged the forced swimming time, increased the PLT counts, and reduced the liver and spleen indices {calculated as follows: organ index (%) = [organ weight (mg)/body weight (g)] ×100%}. In addition, the levels of ROS were upregulated, while the ATP and mtDNA contents were downregulated in ITP model mice. Administration of JPYQSX restored the expression of these mitochondrial molecules to normal levels. Furthermore, JPYQSX also decreased the expressions of SDHA, ClpP, and Lonp1, which are closely related to mitochondrial activity. Conclusions: These findings suggest that JPYQSX prevents antiplatelet sera-mediated platelet destruction in ITP mice and ameliorates fatigue possibly through its effect on mitochondrial function. This study revealed JPYQSX as a potential alternative approach for ITP therapy.

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Section: Discussionmentioning

confidence: 99%

Jianpi Yiqi Shexue ameliorates immune thrombocytopenia related fatigue by regulating mitochondrial function

Zhang¹,

Jia²,

Gao³

et al. 2021

Ann Palliat Med

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“…The precise mechanism may be different from TPO agonist. In TCM theory, a patient with fatigue, nausea, and bone marrow suppression after chemotherapy is often diagnosed as qi and blood deficiency [ 27 ]. CGPEF was composed of 24 CHM to supplement qi and blood.…”

Section: Discussionmentioning

confidence: 99%

“…These formulas have same ingredients recorded in the TCM textbooks, except tiger bone in Hu-Qian-Wan, because it is strictly prohibited in Taiwan. All CHMs have been commonly used for hundreds of years and were often used by TCM doctors to treat qi, blood, and kidney deficiency, which are thought to be the main cause of CIT on TCM's viewpoint [ 24 , 27 ]. The composition of the CGPEF is summarized in Table 1 .…”

Section: Methodsmentioning

confidence: 99%

Use of Chinese Herbal Medicine Improves Chemotherapy‐Induced Thrombocytopenia among Gynecological Cancer Patients: An Observational Study

Chen

Lai

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Background Chemotherapy-induced thrombocytopenia (CIT) is a serious complication among patients with gynecological malignancies, yet management options are limited. This study aimed at reporting the potential of the Chang Gung platelet elevating formula (CGPEF), a prescription with a fixed proportion of Chinese herbs, for improving CIT among gynecologic cancer patients. Materials From 1/1/2007 to 31/12/2009, a total of 23 patients with two consecutive CIT episodes (≤ 100×103 /μL) (last cycle: C0; index cycle: C1) received the CGPEF from the nadir of platelet count of C1 and through the subsequent chemotherapy cycles (C2 and beyond). The CGPEF was taken orally four times a day. The evolution of platelet counts of 18 patients after administration of CGPEF was analyzed (2 patients had different chemotherapy regimens after CGPEF, two patients discontinued CGPEF due to the flavor and the amount of CGPEF, and one patient had no further chemotherapy). Results Most of the patients had recurrent ovarian cancer (11/18, 61%) with a median of 2.5 previous chemotherapy regimens, and carboplatin-based regimens were the most commonly used for these patients (13/18, 72%). The trend of successive CIT could be reversed after taking CGPEF. Also, the platelet nadir was higher after CGPEF treatment (16.5×103/μL versus 32×103/μL, before and after CGPEF treatment, resp., p = 0.002). Moreover, the chemotherapy interval decreased from 30.5 days to 24 days. No thrombocytosis, clinical bleeding, thromboembolism, or other adverse events were found among these patients. Conclusions The CGPEF is worthy of further large-scale, well-designed clinical trials for CIT among gynecological cancer patients.

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“…Herbal medicines, a powerful tool of TCM, can heal different kinds of Zhengs by combinations [4–6]. Although there are substantial records of TCM clinical cases and corresponding analyses of the clinical information [7–9], there is still shortage of scientific explanations for corresponding mechanism. …”

Section: Introductionmentioning

confidence: 99%

A Network-Based Systematic Study for the Mechanism of the Treatment of Zhengs Related to Cough Variant Asthma

Chen

Zhang

Chen

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Traditional Chinese medicine (TCM) has shown significant efficacy in the treatment of cough variant asthma (CVA), a special type of asthma. However, there is shortage of explanations for relevant mechanism of treatment. As Zhengs differentiation is a critical concept in TCM, it is necessary to explain the mechanism of treatment of Zhengs. Based on TCM clinical cases, this study illustrated the mechanism of the treatment of three remarkably relevant Zhengs for CVA: “FengXieFanFei,” “FeiQiShiXuan”, and “QiDaoLuanJi.” To achieve this goal, five steps were carried out: (1) determining feature Zhengs and corresponding key herbs of CVA by analyses of clinical cases; (2) finding out potential targets of the key herbs and clustering them based on their functional annotations; (3) constructing an ingredient-herb network and an ingredient network; (4) identifying modules of the ingredient network; (5) illustrating the mechanism of the treatment by further mining the latent biological implications within each module. The systematic study reveals that the treatment of “FengXieFanFei,” “FeiQiShiXuan,” and “QiDaoLuanJi” has effects on the regulation of multiple bioprocesses by herbs containing different ingredients with functions of steroid metabolism regulation, airway inflammation, and ion conduction and transportation. This network-based systematic study will be a good way to boost the scientific understanding of mechanism of the treatment of Zhengs.

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Multi-central Clinical Research into Treating 80 Cases of Chronic Thrombocytopenia with Qi-supplementing and Yin-nourishing Therapy and Western Medicine

Cited by 8 publications

References 2 publications

Jianpi Yiqi Shexue ameliorates immune thrombocytopenia related fatigue by regulating mitochondrial function

Jianpi Yiqi Shexue ameliorates immune thrombocytopenia related fatigue by regulating mitochondrial function

Use of Chinese Herbal Medicine Improves Chemotherapy‐Induced Thrombocytopenia among Gynecological Cancer Patients: An Observational Study

A Network-Based Systematic Study for the Mechanism of the Treatment of Zhengs Related to Cough Variant Asthma

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