Multi component one pot synthesis and characterization of derivatives of 2-amino-7,7- dimethyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile and study of anti-microbial activity

Abstract

ABSTRACT. An efficient and convenient procedure has been described for one-pot multi-component synthesis of tetrahydrobenzo [b]pyrans known as 2-amino-7,7-dimethyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile which can be obtained from the reaction of substituted aromatic aldehydes, dimedone, malonitrile, in the presence of base such as potassium tertiary butoxide and THF in methanol as solvent at RT condition. All the compounds were examined by advanced spectroscopic data ( 1 H NMR, 13 C NMR and LCMS) and the structural determination was evaluated by elemental analysis. In addition to this, all the newly synthesized compounds were examined for their antibacterial activities and antifungal activity by disc diffusion method against the organism of Aspergillus niger and Candida ablicans L.

New approaches for the synthesis of chromene and quinoline derivatives and their anti-proliferative, morphological studies

“…Such a group of compounds are fairly ubiquitous in nature, as these are found in bacteria, fungi, plants and animals [2][3][4][5]. In medicinal chemistry, the presence of the chromene moiety within the structure of the compound is responsible for its physiological activities, like antineoplastic, anticoagulant, antihypertensive, β-secretase inhibition, antidepressant, antitrypanosomal, anti-HIV, antidyslipidemic, and antimicrobial [6][7][8]. Moreover, the chromene derivatives are important class of compounds as anticancer agents, examples of drugs containing chromene moiety is the crolibulin EPC2407 (Figure 1) which is used as vascular disrupting anticancer drug to treat advanced solid tumors, beside it is currently under phase I/II clinical trials [9,10].…”