The commune of Tamou, located in the Department of Say in Niger, occupies the southwestern part of the Liptako crystallophyllian basement domain. In this area, the problem of the drinking water supply of the populations is acute, because of the low flow rates of the drillings capturing the crystallophyllian formations and the Voltaian sandstones, the failure rates of the drillings are very high there. Therefore, the main objective of this study is to improve the knowledge of the areas potentially favorable for the implantation of drillings likely to give more satisfactory flow rates. The methodological approach, based on the collection of data (Landsat 7 ETM+ satellite imagery, borehole data, geological and topographical maps) and their processing by a combination of remote sensing and GIS tools and a field check, allowed the elaboration of maps of availability, accessibility and exploitability of the groundwater resources in the study area. The maps developed were analyzed with a Spatial Reference Hydrogeological Information System following the technique of aggregation by weighting to generate the map of productive drilling sites. The results show that the area is moderately rich in groundwater (58%) and that only 31% of the potential is exploitable. The groundwater potential map shows that 46% of the study area is suitable for drilling.