2023
DOI: 10.3389/fphar.2023.1282572
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Multi-dimensional role of gangliosides in modulating cancer hallmarks and their prospects in targeted cancer therapy

Abhisek Sarkar,
Sounak Banerjee,
Kaushik Biswas

Abstract: Gangliosides are glycosphingolipids with prevalence in nervous tissue and their involvement in certain neuronal diseases have been widely known. Interestingly, many recent studies highlighted their importance in the development and progression of various cancers through orchestration of multiple attributes of tumorigenesis, i.e., promoting migration, invasion, escaping the host immune system, and influencing other cancer hallmarks. Therefore, the multidimensional role of gangliosides in different cancers has e… Show more

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Cited by 4 publications
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“…Our data demonstrates that both tracers strongly label breast cancer cells 31,32 , both in vitro and in vivo . Additionally, a small subpopulation of non-neuronal host cells in tumors were positive for tracers.…”
Section: Discussionsupporting
confidence: 52%
“…Our data demonstrates that both tracers strongly label breast cancer cells 31,32 , both in vitro and in vivo . Additionally, a small subpopulation of non-neuronal host cells in tumors were positive for tracers.…”
Section: Discussionsupporting
confidence: 52%