This paper presents a modular, flexible, extendable and fast-computational framework that implements a multidisciplinary, varying fidelity, multi-system approach for the conceptual and preliminary design of novel aero-engines. In its current status, the framework includes modules for multi-point steady-state engine design, aerodynamic design, engine geometry and weight, aircraft mission analysis, Nitrogen Oxide (NOx) emissions, control system design and integrated controller-engine transient-performance analysis. All the modules have been developed in the same software environment, ensuring consistent and transparent modeling while facilitating code maintainability, extendibility and integration at modeling and simulation levels. Any simulation workflow can be defined by appropriately combining the relevant modules. Different types of analysis can be specified such as sensitivity, design of experiment and optimization. Any combination of engine parameters can be selected as design variables, and multi-disciplinary requirements and constraints at different operating points in the flight envelope can be specified. The framework implementation is exemplified through the optimization of an ultra-high bypass ratio geared turbofan engine with a variable area fan nozzle, for which specific aircraft requirements and technology limits apply. Although the optimum design resulted in double-digit fuel-burn benefits compared to current technology engines, it did not meet engine-response requirements, highlighting the need to include transient-performance assessments as early as possible in the preliminary engine design phase.