Multi-drug resistant (MDR) and extensively drug-resistant (XDR) bacteraemia rates among cancer patients in an oncology hospital in eastern India: an 11-year retrospective observational study

Mukherjee, Satyam; De, Maitrayee Sarkar; Goel, Gaurav; Bhattacharyya, Arpita; Mallick, Indranil; Dabkara, Deepak; Bhaumik, Jaydip; Roy, Manas Kumar; Majumdar, Piyali Bose; Chatterji, S. N.; Mukherjee, Sudipta Kumer; Bhattacharya, Sanjay; Chandy, Mammen

doi:10.1016/j.infpip.2023.100275

Cited by 7 publications

(6 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These data were, however, not limited to HSCT recipients only but included patients with hematological and solid organ malignancies. Positive blood culture rates were 12.2%–15.8% overall and MDR/XDR BSI rates per 1000 in‐patient encounters were 55%−89.91% and 18.33%−31.11% for 3GCR Gram‐negative bacilli and carbapenem‐resistant Gram‐negative bacilli, respectively 31 …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hematopoietic stem‐cell transplantation in a zoo of multidrug‐resistant organisms: Data from a cancer center in eastern India

Ghosh

Bhattacharya

Goel

et al. 2023

Transplant Infectious Dis

Self Cite

View full text Add to dashboard Cite

BackgroundInfections by multidrug‐resistant organisms (MDRO) are a major hurdle in hematopoietic stem‐cell transplants (HSCTs). Conditioning regimens lead to mucosal barrier injury, which in‐turn leads to transmigration of gut bacteria and sepsis. Pre‐transplant stool and throat surveillance cultures can guide empirical antibiotic policy during the neutropenic period. In this paper, we document colonization with MDRO in pre‐transplant surveillance cultures and the correlation with bloodstream infections in HSCT patients and analyze transplant outcomes with respect to these infections.MethodsA single‐center, retrospective study on HSCT was performed between January 2021 and December 2021. The incidence of bacterial infections, percentage of MDROs, correlation with pre‐transplant stool/throat surveillance cultures, and their impact on overall 100‐day and post‐100‐day to 6‐month post‐transplant survival were analyzed.ResultsSixty‐four patients were included in the study. Pre‐transplant stool surveillance cultures were positive for MDRO in 85.9% of patients. Almost half (48.5%) of the isolates were positive for carbapenemase‐producing genes (mainly New Delhi metallo‐beta‐lactamase‐1 [NDM‐1] and oxacillinase‐48 [OXA‐48]). Eighteen patients (18/64, 28%) had a positive blood culture for MDRO in the peri‐engraftment neutropenic period. Correlation between surveillance and blood cultures was seen in 61% (11/18) of patients. All‐cause mortality was 14.1% (9/64) and 25% (16/64) in patients at 100 days and 6 months post‐HSCT, respectively. The 100‐day and post‐100‐day all‐cause mortality rates were higher in patients with Gram‐negative MDRO bloodstream infections (p < .012 and <.008, respectively).ConclusionMDRO infections can adversely affect HSCT outcomes. Pre‐transplant stool and throat surveillance cultures may guide empirical antibiotic policy and lead to favorable transplant outcomes. image

show abstract

Section: Discussionmentioning

confidence: 99%

“…Gram-negative bacilli and carbapenem-resistant Gram-negative bacilli, respectively. 31 Efforts to control BSI are of paramount importance if transplant outcomes are to be improved in MDR endemic regions such as ours.…”

Section: Discussionmentioning

confidence: 99%

Hematopoietic stem‐cell transplantation in a zoo of multidrug‐resistant organisms: Data from a cancer center in eastern India

Ghosh

Bhattacharya

Goel

et al. 2023

Transplant Infectious Dis

Self Cite

View full text Add to dashboard Cite

show abstract

“…Therefore, it is imperative to understand the antimicrobial resistance patterns of the enterococcal isolates to formulate policy guidelines and recommendations for the treatment of Enterococcus-associated infections. Furthermore, virulent genes responsible for biofilm production need to be studied to elucidate the relationship between biofilm production and antimicrobial resistance [7,14,15]. Enterococcus species inhabit the gut microbiota of the human system and frequently cause biofilm-associated infections, especially among patients admitted to intensive care units and among those who are immunocompromised [16][17][18][19][20].…”

Section: Discussionmentioning

confidence: 99%

Study on Biofilm Formation Among Enterococcus Isolates and Association With Their Antibiotic Resistance Patterns

Nair,

Sankar,

Neelusree

2024

Cureus

View full text Add to dashboard Cite

Background Enterococci are a part of the normal intestinal flora of humans. They have emerged as one of the leading causes of nosocomial infection. The evolved antibiotic resistance mechanisms coupled with the virulence properties of enterococci have made it a successful pathogen. Aim This study aimed to determine the ability of biofilm formation among the clinical enterococci isolates and the antimicrobial resistance pattern of the strains. Materials and methods Clinical samples of patients who attended Saveetha Medical College and Hospital, Chennai, India, over six months. Identification and characterization of Enterococcus species were done using various biochemical tests. Antibiotic susceptibility patterns for each isolate were performed using the Kirby- Bauer disc diffusion method. Results The formation of biofilm formation was detected using the microtiter plate method. In total, 90 Enterococcus species were isolated; Enterococcus faecalis were 63 (70%) , Enterococcus faecium were 25 (28%) and Enterococcus gallinarum were 2 (2%)independently. E. faecalis displayed advanced resistance rates compared to other Enterococcus species. Resistance against penicillin was found in 42 strains (47%) and resistance to ampicillin was observed in 39 strains (43%). This was followed by resistance to high-level gentamicin in 35 strains (39%) and resistance to ciprofloxacin in 32 strains (36%). Resistance to vancomycin and linezolid also were noted in some strains. Conclusion Our results indicate that E. faecalis exhibits an increasing rate of antimicrobial resistance but lower biofilm conformation. The unique traits of E. faecalis raise concerns for the associated infections, especially hospital-acquired infections.

show abstract

“…6 Mukherjee S, et al found 3rdgeneration cephalosporin-resistant GNB as the main cause of MDR bacteremia (57.6%) followed by carbapenem resistant organisms (CRO). 7 Colistinresistant GNBs were detected in 3.0% of the laboratory confirmed diagnoses of BSI; the 3rd-generation cephalosporin-resistant GNB and colistin-resistant GNB included E. coli, Klebsiella, P. aeruginosa, and Acinetobacter spp. The surveillance cultures obtained in a subset of patients showed ranges of 3 rd -generation cephalosporinresistant GNB in 55%-89.91% and carbapenem resistant GNB in 18.33%-31.11% of the cases.…”

mentioning

confidence: 97%

“…The surveillance cultures obtained in a subset of patients showed ranges of 3 rd -generation cephalosporinresistant GNB in 55%-89.91% and carbapenem resistant GNB in 18.33%-31.11% of the cases. 7 Nair A, et al reviewed 135 allogeneic hematopoietic cell transplantation (allo-HCT) recipients, 43 with fluoroquinolone (FQ) prophylaxis and 92 without this prophylaxis. 8 The groups were matched for median age (26 vs. 24.5 years) and the no-antibiotic group of patients had a higher rate of malignant diagnoses (80% vs. 58%), haploidentical transplants (46% vs. 14%), and posttransplant cyclophosphamide use (46% vs. 14%); however, the rates of GNB bacteremia were not significantly different (37% vs. 34%).…”

mentioning

confidence: 99%

Gram-negative bacteremia - 55 years later

Santos,

Sugai,

Santos

2024

RBM

View full text Add to dashboard Cite

Multi-drug resistant (MDR) and extensively drug-resistant (XDR) bacteraemia rates among cancer patients in an oncology hospital in eastern India: an 11-year retrospective observational study

Cited by 7 publications

References 20 publications

Hematopoietic stem‐cell transplantation in a zoo of multidrug‐resistant organisms: Data from a cancer center in eastern India

Hematopoietic stem‐cell transplantation in a zoo of multidrug‐resistant organisms: Data from a cancer center in eastern India

Study on Biofilm Formation Among Enterococcus Isolates and Association With Their Antibiotic Resistance Patterns

Gram-negative bacteremia - 55 years later

Contact Info

Product

Resources

About