Multi-functional P(3HB) microsphere/45S5 Bioglass®-based composite scaffolds for bone tissue engineering

Bioactive glass and glass-ceramic scaffolds for bone tissue engineering

“…Several scaffold fabrication techniques, including foam replication methods, salt or sugar leaching, thermally induced phase separation, microsphere emulsification sintering, electrospinning to form nanofibrous structures, computer assisted rapid prototyping techniques [75,76], textile and foam coating methods [60,77,78], as well as biomimetic approaches [79,80] to optimize the structure, properties and mechanical integrity of scaffolds have been reported in the literature. Comprehensive reviews of the general state-of-the art in scaffold manufacturing and optimization are available [3,4,37,38,77,81].…”

“…In addition, the incorporation of particular ions into the silicate network, such as silver [20][21][22] and boron [26,27], has been investigated in order 6 to develop antibacterial and antimicrobial materials. Bioactive glasses can also serve as vehicle for the local delivery of selected ions being able to control specific cell functions [30,[57][58][59][60][61][62][63][64]. For example, mesoporous BG microspheres have demonstrated enhanced haemostatic activity, as well as reduced clot detection times and increased coagulation rates compared to nonporous microspheres [65].…”

Characterisation of porcine dermis scaffolds decellularised using a novel non-enzymatic method for biomedical applications

“…7 A non-crosslinked matrix, with rougher surfaces, usually provides the ideal topography for cell attachment. 35 This may facilitate migration and proliferation of cells, and eventually promote the revascularisation and dermal regeneration of implanted scaffolds, which may be beneficial when the final clinical application is for tissue remodelling.…”

Development and Applications of Varieties of Bioactive Glass Compositions in Dental Surgery, Third Generation Tissue Engineering, Orthopaedic Surgery and as Drug Delivery System

“…Mesoporous bioactive glass (MBGs) with different compositions impregnated tetracycline has been prepared and their drug release behaviors have been studied (Zhao et al, 2008). Recently, an unique multifunctional bioactive composite scaffold mainly 45S5 Bioglass-based glassceramic scaffolds has been investigated with the potential to enhance cell attachment and to provide controlled delivery of gentamicin for bone tissue engineering (Francis et al, 2010). Composite materials composed of borate bioactive glass and chitosan (designated BGC) were investigated in vitro and in vivo as a new delivery system for teicoplanin in the treatment of chronic osteomyelitis induced by methicillin-resistant Staphylococcus aureus (MRSA) and demonstrated that this system is effective in treating chronic osteomyelitis by providing a sustained release of teicoplanin, in addition to participating in bone regeneration (Jia et al, 2010).…”

“…Many scaffold fabrication techniques have been reported in the literature, e.g., foam replication methods, salt or sugar leaching, thermally induced phase separation, microsphere emulsification sintering, electrospinning for nano-fibrous structures, computer aided rapid prototyping techniques (Yang et al, 2002;Yun et al, 2007), textile and foam coating methods (De Diego et al, 2000;Francis et al, 2010;Mohamad Yunos et al, 2008) and biomimetic approach (Oliveira et al, 2003;Taboas et al, 2003). All of these methods were done to optimize the structure, properties and mechanical integrity of scaffolds.…”