Natural scene image classification problems can be showed by multi-instances multi-labels learning model (MIML), and MIMLRBF algorithm achieved good effect. MIMLRBF algorithm is based on the clustering technology and neural network for classification. Related experiments show that the measure of the package and the selection of the cluster center have an important impact on the result of image classifications, in order to obtain better clustering accuracy, first of all, this article introduced the spectral clustering method in the training process, which can make the sample package center more reasonable; Second, we redefined the distance between the sample packages, to overcome effectively the influence of the isolated examples on the distance to the sample packages. The experimental results show that the proposed approach can effectively improve the classification accuracy, and it is better than MIMLRBF algorithm on the various performance.