The mechanical response behavior and multi-scale simulation methods of organic ballistic fibers were summarized in this paper, including aramid fibers, ultra-high molecular weight polyethylene fibers, and their composites. Simulation methods are summarized, and the current common problems of multi-scale simulation methods are analyzed in the article. The author is convinced that the application of multi-scale simulation methods of organic fibers with core-skin structure can effectively predict the macroscopic mechanical properties of composite materials and explain the mechanism and mechanical behavior evolution.