Multi-material 3D bioprinting of porous constructs for cartilage regeneration

Ruiz‐Cantu, Laura; Gleadall, Andrew; Faris, Callum; Segal, Joel; Shakesheff, Kevin M.; Yang, Jing

doi:10.1016/j.msec.2019.110578

Cited by 89 publications

(82 citation statements)

References 44 publications

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“…To print the framework, the biomaterial ink should have good printability without clogging and flexible versatility in each printing condition. Polycaprolactone (PCL), 34 , 35 polydimethylsiloxane (PDMS), 36 , 37 and their derivatives can provide physical and mechanical support to in vitro models with little influence on the cells or cellular behaviors based on their biocompatibility.…”

Section: Advances In 3d Bioprintingmentioning

confidence: 99%

Application of 3D bioprinting in the prevention and the therapy for human diseases

Kim

Kwon

et al. 2021

Sig Transduct Target Ther

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Rapid development of vaccines and therapeutics is necessary to tackle the emergence of new pathogens and infectious diseases. To speed up the drug discovery process, the conventional development pipeline can be retooled by introducing advanced in vitro models as alternatives to conventional infectious disease models and by employing advanced technology for the production of medicine and cell/drug delivery systems. In this regard, layer-by-layer construction with a 3D bioprinting system or other technologies provides a beneficial method for developing highly biomimetic and reliable in vitro models for infectious disease research. In addition, the high flexibility and versatility of 3D bioprinting offer advantages in the effective production of vaccines, therapeutics, and relevant delivery systems. Herein, we discuss the potential of 3D bioprinting technologies for the control of infectious diseases. We also suggest that 3D bioprinting in infectious disease research and drug development could be a significant platform technology for the rapid and automated production of tissue/organ models and medicines in the near future.

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Section: Advances In 3d Bioprintingmentioning

confidence: 99%

Application of 3D bioprinting in the prevention and the therapy for human diseases

Kim

Kwon

et al. 2021

Sig Transduct Target Ther

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“…C) Example adjustment to the print-path (moving the nozzle outside of the structure) [30]. D) Example print-path with multiple materials printed at different heights above the print platform in a designed non-sequential manner [3]. E) An identical print-path was used to print several different graded meshes, by designing a variable extrusion width [31].…”

Section: Figurementioning

confidence: 99%

“…In the last twenty years, material extrusion additive manufacturing (MEAM) has grown from a prototyping technology to one that produces intricate structures such as tissue engineering scaffolds [1][2][3], electronic components [4][5][6] and spatially designed fibre-reinforced components [7,8]. MEAM also has the ability to use materials that are difficult to process with other manufacturing technologies such as cell-laden hydrogels [3,9,10] and ceramics [11][12][13]. These materials and applications are generally associated with a shift in the use of MEAM technology towards higher value applications, where fidelity and defects are critical, as opposed to prototyping.…”

Section: Introductionmentioning

confidence: 99%

FullControl GCode Designer: Open-source software for unconstrained design in additive manufacturing

Gleadall

2021

Additive Manufacturing

Self Cite

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A new concept is presented for the design of additive manufacturing procedures, which is implemented in open-source software called FullControl GCode Designer. In this new design approach, the user defines every segment of the print-path along with all printing parameters, which may be related to geometric and non-geometric factors, at all points along the print-path. Machine control code (GCode) is directly generated by the software, without the need for any programming skills and without using computer-aided design (CAD), STL-files or slicing software. Excel is used as the front end for the software, which is written in Visual Basic. Case studies are used to demonstrate the broad range of structures that can be designed using the software, Conformal lattice cells Conformal lattice cells Designed terminal lattice cells Directly design GCode (machine code) • No CAD • No STL files • No slicer software Mathematically define print-paths Systematically control all printing parameters Produce previously inconceivable geometric structures Achieve unparalleled printing quality with precise control of the process Draw strings < 1/10th nozzle diameter

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“…In the fabricated structure, the mixture composed of GelMA and CS-EME was observed to be the best substitute for cartilage formation. Ruiz-Cantu et al developed a hybrid structure composed of PCL and chondrocyte-laden GelMA [167]. To manufacture an ideal structure, the temperature, needle gauge, crosslinking time, and different concentrations of GelMA were evaluated.…”

Section: Cartilagementioning

confidence: 99%

Current Advances in 3D Bioprinting Technology and Its Applications for Tissue Engineering

Park

Kim

et al. 2020

Polymers

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Three-dimensional (3D) bioprinting technology has emerged as a powerful biofabrication platform for tissue engineering because of its ability to engineer living cells and biomaterial-based 3D objects. Over the last few decades, droplet-based, extrusion-based, and laser-assisted bioprinters have been developed to fulfill certain requirements in terms of resolution, cell viability, cell density, etc. Simultaneously, various bio-inks based on natural–synthetic biomaterials have been developed and applied for successful tissue regeneration. To engineer more realistic artificial tissues/organs, mixtures of bio-inks with various recipes have also been developed. Taken together, this review describes the fundamental characteristics of the existing bioprinters and bio-inks that have been currently developed, followed by their advantages and disadvantages. Finally, various tissue engineering applications using 3D bioprinting are briefly introduced.

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Multi-material 3D bioprinting of porous constructs for cartilage regeneration

Cited by 89 publications

References 44 publications

Application of 3D bioprinting in the prevention and the therapy for human diseases

Application of 3D bioprinting in the prevention and the therapy for human diseases

FullControl GCode Designer: Open-source software for unconstrained design in additive manufacturing

Current Advances in 3D Bioprinting Technology and Its Applications for Tissue Engineering

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