Following the conceptual phase of aircraft design, sizing and performance estimations shift from historical-based empirical equations to physics-based simulations. The initial aircraft configuration is refined with a larger number of objectives and requirements, and certification regulations play a critical role in defining these. Analysis tools in the early phases of preliminary design have an important trade-off between accuracy, complexity, and computational efficiency. A number of analysis frameworks currently exist with varying levels of fidelity, multidisciplinary coupling, and limitations in the number of disciplines, degrees of freedom, and requirements they are able to implement. To enable efficient design space exploration (DSE), this paper proposes an integrated preliminary design framework that couples aerodynamics, structures, subsystems, aircraft performance, flight dynamics, and certification testing at varying levels of fidelity. This framework serves as a numerical testbed that can be used to explore the aircraft configuration and disciplinary design spaces, strength of disciplinary couplings, and propagate disciplinary uncertainties across the entire aircraft system. The framework is demonstrated using the horizontal tail of a large twin-aisle aircraft as a test case.