Real-time drive cycles and driving trends have a vital impact on fuel consumption and emissions in a vehicle. To address this issue, an original and alternative approach which incorporates the knowledge about real-time drive cycles and driving trends into fuzzy logic control strategy was proposed. A machine learning framework called MC_FRAME was established, which includes two neural networks for self-learning and making predictions. An intelligent fuzzy logic control strategy based on the MC_FRAME was then developed in a hybrid electric vehicle system, which is called FLCS_MODEL. Simulations were conducted to evaluate the FLCS_MODEL using ADVISOR. The simulation results indicated that comparing with the default controller on the drive cycle NEDC, the FLCS_MODEL saves 12.25% fuel per hundred kilometers, with the HC emissions increasing by 22.7%, the CO emissions reducing by 16.5%, the NOx emissions reducing by 37.5% and with the PM emissions reducing by 12.9%. A conclusion can be drawn that the proposed approach realizes fewer fuel consumption and less emissions.