The 3D multiphase computational fluid dynamic (CFD) models have been developed for gas−liquid systems in a standard baffled stirred tank reactor (diameter 0.3 m) for non-Newtonian power-law fluids. The standard k-ε model has been used to model the turbulence, and drag has been modeled with the Grace drag model with Brucato modifications. CFD simulations have been carried out for three impellers, namely, the Rushton turbine, pitched blade turbine, and hydrofoil impeller. The effects of impeller design, power input per unit volume of the fluid (P/V) (1200− 5200 W/m 3 ), fluid rheology (K = 0−0.1561 Pa•s n , n = 0.687−1.000), and superficial gas velocity (7.1−28.3 mm/s) have been analyzed. The CFD model has been validated with the local distribution of axial, radial, and tangential velocities and overall gas holdup data reported in the literature. The CFD model has been used to predict the regime transition from flooding to loading and complete dispersion. A good agreement was observed for the prediction of regime transition for the Rushton turbine when compared with the experimental data. The average value of absolute error for the prediction of the gas holdup is 20%, which indicates that the developed CFD model can be successfully used to predict the gas holdup and regime transition in stirred tank reactors. Among the impellers studied, the hydrofoil impeller shows the highest gas holdup and uniform gas distribution in the vessel at low power consumption.