“…Similarly, there are many machine learning methods available to solve these problems, such as multiinstance lazy learning algorithms [43], multi-instance tree learners [8], multi-instance rule inducers [9], multi-instance bayesian approaches [27], multi-instance kernel methods [22,38], multi-instance ensembles [45,51], and evolutionary algorithms [48,50]. However, most of the MIL algorithms are very slow and cannot be applied to large data sets.…”