Multi-outcome meta-analysis (MOMA) of cognitive remediation in schizophrenia: Revisiting the relevance of human coaching and elucidating interplay between multiple outcomes

Kambeitz-Ilankovic, Lana; Betz, Linda T.; Dominke, Clara; Haas, Shalaila S.; Subramaniam, Karuna; Fisher, Melisa; Vinogradov, Sophia; Koutsouleris, Nikolaos; Kambeitz, Joseph

doi:10.1016/j.neubiorev.2019.09.031

Cited by 78 publications

(47 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the first one, 67 studies (n = 4067) demonstrated significant effects of cognitive remediation not only on cognitive domains, but also symptoms. Subsequent statistical modeling suggested that improving cognitive symptoms led to improvements in psychosocial functioning, which in turn facilitated improvements in symptoms ( Kambeitz-Ilankovic, 2019 ). In another meta -analysis on CR’s effects, 15 studies showed small to moderate effects on negative symptoms compared to treatment as usual, again, suggesting that activation of cognitive resources may lead to reductions in symptoms ( Cella, 2017 ).…”

Section: Conclusion and Discussionmentioning

confidence: 99%

Modulation of frontal gamma oscillations improves working memory in schizophrenia

Singh

Shu

Hsu

et al. 2020

NeuroImage: Clinical

View full text Add to dashboard Cite

Highlights Cognitive deficits, a core symptom of schizophrenia, are difficult to treat with available therapies. Abnormal neural dynamics of frontal gamma oscillations contribute to these deficits. Neurofeedback has been used previously to alter brain oscillations. Gamma band neurofeedback can impact brain and behavioral markers of cognition.

show abstract

Section: Conclusion and Discussionmentioning

confidence: 99%

Modulation of frontal gamma oscillations improves working memory in schizophrenia

Singh

Shu

Hsu

et al. 2020

NeuroImage: Clinical

View full text Add to dashboard Cite

show abstract

“…This reflects the need to incorporate the experimental intervention into the intensive treatment package that is routinely offered in our clinical setting. We cannot exclude the possibility that improvers would have shown a significant improvement in outcomes after longer or more diversified CCT protocols ( 61 ). However, the most prominent changes in sensory processing, tightly linked to heterogeneity in neuroplastic response to CCT, have been shown in the early stages of the training, whereas it has been suggested that after 20 h of CCT sensory processing undergoes less change ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

Modeling Social Sensory Processing During Social Computerized Cognitive Training for Psychosis Spectrum: The Resting-State Approach

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background: Greater impairments in early sensory processing predict response to auditory computerized cognitive training (CCT) in patients with recent-onset psychosis (ROP). Little is known about neuroimaging predictors of response to social CCT, an experimental treatment that was recently shown to induce cognitive improvements in patients with psychosis. Here, we investigated whether ROP patients show interindividual differences in sensory processing change and whether different patterns of SPC are (1) related to the differential response to treatment, as indexed by gains in social cognitive neuropsychological tests and (2) associated with unique resting-state functional connectivity (rsFC).Methods: Twenty-six ROP patients completed 10 h of CCT over the period of 4–6 weeks. Subject-specific improvement in one CCT exercise targeting early sensory processing—a speeded facial Emotion Matching Task (EMT)—was studied as potential proxy for target engagement. Based on the median split of SPC from the EMT, two patient groups were created. Resting-state activity was collected at baseline, and bold time series were extracted from two major default mode network (DMN) hubs: left medial prefrontal cortex (mPFC) and left posterior cingulate cortex (PCC). Seed rsFC analysis was performed using standardized Pearson correlation matrices, generated between the average time course for each seed and each voxel in the brain.Results: Based on SPC, we distinguished improvers—i.e., participants who showed impaired performance at baseline and reached the EMT psychophysical threshold during CCT—from maintainers—i.e., those who showed intact EMT performance at baseline and sustained the EMT psychophysical threshold throughout CCT. Compared to maintainers, improvers showed an increase of rsFC at rest between PCC and left superior and medial frontal regions and the cerebellum. Compared to improvers, maintainers showed increased rsFC at baseline between PCC and superior temporal and insular regions bilaterally.Conclusions: In ROP patients with an increase of connectivity at rest in the default mode network, social CCT is still able to induce sensory processing changes that however do not translate into social cognitive gains. Future studies should investigate if impairments in short-term synaptic plasticity are responsible for this lack of response and can be remediated by pharmacological augmentation during CCT.

show abstract

“…They observed stronger associations between cognition and oQOL, but reported tenuous links with sQOL. Additionally, current evidence from cognitive remediation therapy 1 (CRT) studies suggest that improved cognition is only associated with improved oQOL [2,3], while the effect on sQOL is still unclear. Given the growing focus on sQOL as a treatment outcome, and the increased importance afforded to patient perceptions of recovery [4], it is critical that the determinants of sQOL are better understood.…”

Section: Introductionmentioning

confidence: 99%

Impaired meaning-based cognitive skills are specifically associated with poorer subjective quality of life in schizophrenia

Tan

Rossell

Lee

2020

Personalized Medicine in Psychiatry

View full text Add to dashboard Cite

Multi-outcome meta-analysis (MOMA) of cognitive remediation in schizophrenia: Revisiting the relevance of human coaching and elucidating interplay between multiple outcomes

Cited by 78 publications

References 57 publications

Modulation of frontal gamma oscillations improves working memory in schizophrenia

Modulation of frontal gamma oscillations improves working memory in schizophrenia

Modeling Social Sensory Processing During Social Computerized Cognitive Training for Psychosis Spectrum: The Resting-State Approach

Impaired meaning-based cognitive skills are specifically associated with poorer subjective quality of life in schizophrenia

Contact Info

Product

Resources

About