Multi-Parametric Optical Glucose Sensor Based on Surface Functionalized Nano-Porous Silicon

Basu, Deeparati; Sarkar, Tanusree; Sen, Kaustav; Hossain, Syed Minhaz; Das, Jayoti

doi:10.1109/jsen.2018.2872846

Cited by 16 publications

(11 citation statements)

References 32 publications

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“…As mentioned below, biofunctionalization plays a very important role in bioselective layer evolution and allows for the binding of organic molecules to a non-organic nano-Si surface without unspecific interaction. Currently, a number of biofunctionalization protocols have been proposed: silanization [3,19,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67], aminosilanization [68,69,70], direct immobilization [16,22,71,72], enzyme [18] or peptide [73] treatment, phospholipid bilayers formation [74], hydrosilylation treated by N-Hydroxysuccinimide and 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (NHS/EDC) [75,76,77] or resazurin [78], and polymer synthesis [79]. However, the most common technique is silanization, due to the possibility of controlling the thickness of the(3-Aminopropyl)triethoxysilane (APTES) layer as well as using different cross-linking agents (glutaraldehyde, NHS/EDS) [18,80].…”

Section: (Bio)sensors Based On Psi Sinws Sinps and Their Composimentioning

confidence: 99%

“…Another nano-Si optical response suitable for (bio)molecule detection is reflectance or other optical parameters related to reflectance [22,48,53,55,56,57,58,62,65,67,68,70,71,74,76,85,86,87,88,89,90,91,92,93,94,95,96]. Generally, the (bio)sensor technique based on reflectance response can be performed via reflective index (RI) [71] or optical density [16] (OD) measurements in the initial state and after the addition of the analyte.…”

Section: (Bio)sensors Based On Psi Sinws Sinps and Their Composimentioning

confidence: 99%

“…Nowadays, sensors and biosensors based on nano-Si have been successfully applied to molecules [15], biomolecules [16] and light [17] detection using different responses (PL [18,19], SERS [20], I–V [21], reflectance [22,23], resistance [24], capacitance [25], fluorescence [26]) and material modifications (PSi, SiNWs, SiNPs). Such strong interest in (bio)sensors based on nano-Si can be explained by their enhanced surface to volume ratio, biocompatibility, and low-cost.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nanosilicon-Based Composites for (Bio)sensing Applications: Current Status, Advantages, and Perspectives

Myndrul

Iatsunskyi

2019

Materials

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This review highlights the application of different types of nanosilicon (nano-Si) materials and nano-Si-based composites for (bio)sensing applications. Different detection approaches and (bio)functionalization protocols were found for certain types of transducers suitable for the detection of biological compounds and gas molecules. The importance of the immobilization process that is responsible for biosensor performance (biomolecule adsorption, surface properties, surface functionalization, etc.) along with the interaction mechanism between biomolecules and nano-Si are disclosed. Current trends in the fabrication of nano-Si-based composites, basic gas detection mechanisms, and the advantages of nano-Si/metal nanoparticles for surface enhanced Raman spectroscopy (SERS)-based detection are proposed.

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Section: (Bio)sensors Based On Psi Sinws Sinps and Their Composimentioning

confidence: 99%

Section: (Bio)sensors Based On Psi Sinws Sinps and Their Composimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nanosilicon-Based Composites for (Bio)sensing Applications: Current Status, Advantages, and Perspectives

Myndrul

Iatsunskyi

2019

Materials

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“…The complications due to the fluctuation of blood glucose can be avoided by closely and accurately monitoring the blood glucose level through accurate biosensors [ 8 ]. Based on the sensing principle, several types of biosensors are available such as an optical type, a capacitive type, a piezoelectric type, an electrochemical type, and a microwave type [ 9 , 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

High-Sensitivity, Quantified, Linear and Mediator-Free Resonator-Based Microwave Biosensor for Glucose Detection

Kumar

Wang

Meng

et al. 2020

Sensors

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This article presents a high-sensitivity, quantified, linear, and mediator-free resonator-based microwave biosensor for glucose sensing application. The proposed biosensor comprises an air-bridge-type asymmetrical differential inductor (L) and a center-loaded circular finger-based inter-digital capacitor (C) fabricated on Gallium Arsenide (GaAs) substrate using advanced micro-fabrication technology. The intertwined asymmetrical differential inductor is used to achieve a high inductance value with a suitable Q-factor, and the centralized inter-digital capacitor is introduced to generate an intensified electric field. The designed microwave sensor is optimized to operate at a low resonating frequency that increases the electric field penetration depth and interaction area in the glucose sample. The microwave biosensor is tested with different glucose concentrations (0.3–5 mg/ml), under different ambient temperatures (10–50 °C). The involvement of advanced micro-fabrication technology effectively miniaturized the microwave biosensor (0.006λ0 × 0.005λ0) and enhanced its filling factor. The proposed microwave biosensor demonstrates a high sensitivity of 117.5 MHz/mgmL-1 with a linear response (r2 = 0.9987), good amplitude variation of 0.49 dB/mgmL-1 with a linear response (r2 = 0.9954), and maximum reproducibility of 0.78% at 2 mg/mL. Additionally, mathematical modelling was performed to estimate the dielectric value of the frequency-dependent glucose sample. The measured and analyzed results indicate that the proposed biosensor is suitable for real-time blood glucose detection measurements.

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“…The displacement of the spectral response of the PSi microstructures is linked to the refractive index (RI) variation of the medium filling the pores, whereas this is caused by the infiltration of gas, liquid or the adhesion of target analytes to the pore walls [14][15][16]. Previous studies have demonstrated a very low LoD of PSi-based sensors, down to 10 -7 RIU [10,17], which has enabled the detection of biomolecules in a concentration range of interest for multiple biomedical applications [18,19]. It has also been proved that PSi-based RI sensors can reach sensitivities on the order of 10 3 nm/RIU, much higher than the ones that can be obtained with non-porous sensors with a similar Q-factor [10,20].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Refractive Index Sensing Using an Array of Suspended Porous Silicon Membranes

2020

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We propose a fast and cost-effective method for obtaining a miniaturized array-formatted sensor suitable for multiplexed detection. Our solution is based on the fabrication of multiple µm-sized suspended porous silicon (PSi) membranes working as independent transducers. Our process can potentially integrate an array of up to 1000 sensing spots per cm 2. We also propose a simple and user-friendly optical platform to simultaneously interrogate each element of the array in real-time. The feasibility of this idea was proved performing several sensing experiments where we were able to detect refractive index (RI) variations with different transducers at the same time. An average experimental sensitivity of 685 nm/RIU (Refractive Index Unit) was achieved, with a theoretical limit of detection (LoD) of 10-5 RIU. The analyzed sensing spots displayed similar behavior both in time and in magnitude. We believe that the high capabilities of the sensor presented in this work, along with the sensing mechanism, can be very useful for multi-parametric analysis and multi-target detection of biological samples.

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Multi-Parametric Optical Glucose Sensor Based on Surface Functionalized Nano-Porous Silicon

Cited by 16 publications

References 32 publications

Nanosilicon-Based Composites for (Bio)sensing Applications: Current Status, Advantages, and Perspectives

Nanosilicon-Based Composites for (Bio)sensing Applications: Current Status, Advantages, and Perspectives

High-Sensitivity, Quantified, Linear and Mediator-Free Resonator-Based Microwave Biosensor for Glucose Detection

Simultaneous Refractive Index Sensing Using an Array of Suspended Porous Silicon Membranes

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