Multi-Push (MP) acoustic radiation force (ARF) ultrasound for assessing tissue viscoelasticity, in vivo

Scola, Mallory R.; Baggesen, Leslie M.; Gallippi, Caterina M.

doi:10.1109/embc.2012.6346428

Cited by 9 publications

(7 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…) typical of viscoelastic tissues such as the kidney (Scola et al. ). The second component began immediately after the initial short peak as a slow and progressive increase in ΔRIHP that reached a stable maximum 45 min after the rmDIVE.…”

Section: Discussionmentioning

confidence: 99%

Highly suggestive preliminary evidence that the renal interstitium contracts in vivo

et al. 2017

View full text Add to dashboard Cite

To learn more about controlling renal interstitial hydrostatic pressure (RIHP), we assessed its response to renal medullary direct interstitial volume expansion (rmDIVE = 100 μL bolus infusion/30 sec). Three experimental series (S) were performed in hydropenic, anesthetized, right‐nephrectomized, acute left renal‐denervated and renal perfusion pressure‐controlled rats randomly assigned to groups in each S. S1: Rats without hormonal clamp were contrasted before and after rmDIVE induced via 0.9% saline solution bolus (SS group) or 2% albumin in SS bolus (2% ALB + SS group). Subcapsular ΔRIHP rose slowly, progressively and similarly in both groups by ~3 mmHg. S2: Rats under hormonal clamp were contrasted before and after sham rmDIVE (time CTR group) and real rmDIVE induced via either SS bolus (SS group) or SS bolus containing the subcutaneous tissue fibroblast relaxant dibutyryl‐cAMP (SS + db‐cAMP group). ΔRIHP showed time, group, and time*group interaction effects with a biphasic response (early: ~1 mmHg; late: ~4 mmHg) in the SS group that was absent in the SS + db‐cAMP group. S3: Two groups of rats (SS and SS + db‐cAMP) under hormonal clamp were contrasted as in S2, producing similar ΔRIHP results to those of S2 but showing a slow, progressive, and indistinct decrease in renal outer medullary blood flow in both groups. These results provide highly suggestive preliminary evidence that the renal interstitium is capable of contracting reactively in vivo in response to rmDIVE with SS and demonstrate that such a response is abolished when db‐cAMP is interstitially and concomitantly infused.

show abstract

Section: Discussionmentioning

confidence: 99%

Highly suggestive preliminary evidence that the renal interstitium contracts in vivo

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The linear viscoelasticity of tissue follows the Voigt model, as it is simple and effective in modeling the visco elastic behavior of soft tissue and tissue mimicking phantoms [5,7,15], In ARF creep imaging, the creep response of viscoelastic soft tissue has been studied with the relation [7,[9][10][11],…”

Section: Sdf Models In Acoustic Radiation Force Creep Imagingmentioning

confidence: 99%

“…Alterna tively, the ARF induced creep imaging methods use the responses in the region of excitation where the measured displacements have a high SNR. In these methods, SDF models that represent point-by-point characteristics have been used to model the relation ' between the creep displacement and the step ARF [7][8][9][10][11], Conse quently, the soft tissue viscoelasticity can be estimated by fitting these simplified models with the measured time-dependent creep displacement. The physical basis for the SDF assumption is that the ARF induced motion is highly localized, and the response of the tissue is assumed to be only related to the local distribution of the mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Dynamic Simulation of Viscoelastic Soft Tissue in Acoustic Radiation Force Creep Imaging

Zhao

Pelegri

2014

Journal of Biomechanical Engineering

View full text Add to dashboard Cite

Acoustic radiation force (ARF) creep imaging applies step ARF excitation to induce creep displacement of soft tissue, and the corresponding time-dependent responses are used to estimate soft tissue viscoelasticity or its contrast. Single degree of freedom (SDF) and homogeneous analytical models have been used to characterize soft tissue viscoelasticity in ARF creep imaging. The purpose of this study is to investigate the fundamental limitations of the commonly used SDF and homogeneous assumptions in ARF creep imaging. In this paper, finite element (FE) models are developed to simulate the dynamic behavior of viscoelastic soft tissue subjected to step ARF. Both homogeneous and heterogeneous models are studied with different soft tissue viscoelasticity and ARF configurations. The results indicate that the SDF model can provide good estimations for homogeneous soft tissue with high viscosity, but exhibits poor performance for low viscosity soft tissue. In addition, a smaller focal region of the ARF is desirable to reduce the estimation error with the SDF models. For heterogeneous media, the responses of the focal region are highly affected by the local heterogeneity, which results in deterioration of the effectiveness of the SDF and homogeneous simplifications.

show abstract

“…Several ultrasound elastography techniques currently exist that can be used to determine the shear viscosity of a material. These include direct inversion of the Helmholtz equation from vibrating needle stimulation displacement data [6], exciting tissues with monochromatic shear waves as in Shear Wave Dispersion Ultrasound Vibrometry (SDUV) [7], measuring the dispersion of crawling waves [8], observing the creep response of tissues under acoustic radiation force (ARF) [9], and calculating the relaxation time constant [10] following ARF excitation. The effect of viscosity on transient shear waves used in Supersonic Shear Wave Imaging (SSI) has also been investigated [11].…”

Section: Introductionmentioning

confidence: 99%

Single tracking location acoustic radiation force impulse viscoelasticity estimation (STL-VE): A method for measuring tissue viscoelastic parameters

Langdon

Elegbe

McAleavey

2015

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

View full text Add to dashboard Cite

Single Tracking Location (STL) Shear wave Elasticity Imaging (SWEI) is a method for detecting elastic differences between tissues. It has the advantage of intrinsic speckle bias suppression compared to Multiple Tracking Location (MTL) variants of SWEI. However, the assumption of a linear model leads to an overestimation of the shear modulus in viscoelastic media. A new reconstruction technique denoted Single Tracking Location Viscosity Estimation (STL-VE) is introduced to correct for this overestimation. This technique utilizes the same raw data generated in STL-SWEI imaging. Here, the STL-VE technique is developed by way of a Maximum Likelihood Estimation (MLE) for general viscoelastic materials. The method is then implemented for the particular case of the Kelvin-Voigt Model. Using simulation data, the STL-VE technique is demonstrated and the performance of the estimator is characterized. Finally, the STL-VE method is used to estimate the viscoelastic parameters of ex-vivo bovine liver. We find good agreement between the STL-VE results and the simulation parameters as well as between the liver shear wave data and the modeled data fit.

show abstract

Multi-Push (MP) acoustic radiation force (ARF) ultrasound for assessing tissue viscoelasticity, in vivo

Cited by 9 publications

References 24 publications

Highly suggestive preliminary evidence that the renal interstitium contracts in vivo

Highly suggestive preliminary evidence that the renal interstitium contracts in vivo

Dynamic Simulation of Viscoelastic Soft Tissue in Acoustic Radiation Force Creep Imaging

Single tracking location acoustic radiation force impulse viscoelasticity estimation (STL-VE): A method for measuring tissue viscoelastic parameters

Contact Info

Product

Resources

About