Multi-residue method for the determination of basic/neutral pharmaceuticals and illicit drugs in surface water by solid-phase extraction and ultra performance liquid chromatography–positive electrospray ionisation tandem mass spectrometry

Kasprzyk-Hordern, Barbara; Dinsdale, Richard M.; Guwy, Alan J.

doi:10.1016/j.chroma.2007.05.074

Cited by 354 publications

(196 citation statements)

References 35 publications

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“…They were used in majority of studies (see Table 1) and have been selected for the extraction of TCs and MLs since they are silanol free avoiding the antibiotics binding. Only two works used Oasis MCX (mixed cation exchange) cartridges [1,2]. In four works Strata X cartridges were employed for the extraction of SAs, MLs and pharmaceuticals from environmental waters [26,[38][39][40].…”

Section: Sample Pre-treatment and Extraction Proceduresmentioning

confidence: 99%

“…2 and 3) [1,16]. UHPLC is a modern technique, using columns packed with sub-2 m particles, which enabled elution of sample components in much narrower, more concentrated bands, resulting in better chromatographic resolution and increased peak capacity through rapid elution from short column.…”

Section: Chromatographymentioning

confidence: 99%

“…Secondly, contaminants in the sample matrix may interfere with the analyte peaks by raising the chromatogram baseline. Thirdly, contaminants may reduce the ionization efficiency of the analytes by taking up some of the limited number of excess charged sites on the surfaces of electrospray droplets [1,18,41]. Previously cited work studied the signal suppression [18].…”

Section: Matrix Effectsmentioning

confidence: 99%

“…13 C-phenacetin was used very often in studies where antibiotics were analyzed together with other pharmaceuticals [1,24,27,38,40,41,61]. Although simatone or phenacetin are good ISs, it is desirable that both IS and target compounds should have the structural similarities in order to reflect the properties of the target compound during the entire analytical procedure.…”

Section: Internal Standardmentioning

confidence: 99%

“…Pharmaceuticals have been found in surface waters and wastewaters at levels of up to a few g L −1 . Antibiotics, followed by steroid compounds, analgesics/nonsteroidal and anti-inflammatory drugs, are the most widely studied classes of pharmaceuticals [1].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

An overview of analytical methodologies for the determination of antibiotics in environmental waters

Seifrtová¹,

Nováková²,

Lino³

et al. 2009

Analytica Chimica Acta

322

170

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a b s t r a c tThe widespread occurrence of antibiotics as contaminants in the aquatic environment has increased attention in the last years. The concern over the release of antibiotics into the environment is related primarily to the potential for the development of antimicrobial resistance among microorganisms. This article presents an overview of analytical methodologies for the determination of quinolone (Qs) and fluoroquinolone (FQs), macrolide (MLs), tetracycline (TCs), sulfonamide (SAs) antibiotics and trimethoprim (TMP) in different environmental waters. The analysis of these antibiotics has usually been carried out by high-performance liquid chromatography (HPLC) coupled to mass spectrometry (MS) or tandem mass spectrometry (MS/MS) and to a lesser extent by ultraviolet (UV) or fluorescence detection (FD). A very important step before LC analysis is sample preparation and extraction leading to elimination of interferences and prevention of matrix effect and preconcentration of target analytes.

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Section: Sample Pre-treatment and Extraction Proceduresmentioning

confidence: 99%

Section: Chromatographymentioning

confidence: 99%

Section: Matrix Effectsmentioning

confidence: 99%

Section: Internal Standardmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

An overview of analytical methodologies for the determination of antibiotics in environmental waters

Seifrtová¹,

Nováková²,

Lino³

et al. 2009

Analytica Chimica Acta

322

170

View full text Add to dashboard Cite

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Pharmaceuticals and Hormones in the Environment

Jones-Lepp

Alvarez²,

Englert

et al. 2009

Encyclopedia of Analytical Chemistry

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Some of the earliest initial reports from Europe and the United States demonstrated that a variety of pharmaceuticals and hormones could be found in surface waters, source waters, drinking water, and influents and effluents from wastewater treatment plants (WWTPs). It is unknown though, at this time, what ecotoxicological effects can be had from pharmaceuticals and hormones that are essentially designed for one purpose (e.g., treatment of human and domestic livestock for illness and disease) and their possible adverse effects on terrestrial wildlife, aquatic organisms, bacteria, and ultimately humans, through unintentional environmental exposure. One of the challenges the analytical chemistry community faces is the development of robust and standardized analytical methods and technologies that can easily be transferred to laboratories worldwide. While today's analysts can detect picograms per liter and nanograms per liter concentrations of numerous pharmaceuticals, hormones, and their metabolites, in a variety of environmental matrices, there are still analytical gaps that are necessary to fill. We hope that this article will add to the body of knowledge of environmental analytical chemistry techniques regarding pharmaceuticals and hormones, giving environmental scientists a good overview of those analytical techniques that are currently available, and where possible, of improvements and new methodologies that can be developed in support of this important, and relevant, environmental issue.

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New Sample Preparation Strategies for Analytical Determinations

Quintana

Ramil

Rodil

et al. 2014

Encyclopedia of Analytical Chemistry

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Sample preparation techniques have experienced an explosive development during the past decades. Procedural approached that uses minimal sample amounts reducing to the limit and sometimes eliminating completely the use of toxic and/or environmentally unfriendly solvents and reagents have emerged as standard in the analytical laboratory. At the same time, significant improvements in sensitivity and selectivity have appeared. This article revisited the principal developments of sample preparation methods for analytical determinations as produced recently. The approach is systematic, classifying the procedures into two broad groups: methods based on equilibrium and exhaustive methods. In each case, the principal methods are revisited with a brief description about the principles and chemistry involved and some examples in each case. A large number of bibliographic references allow a deeper study on each case, when necessary.

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Multi-residue method for the determination of basic/neutral pharmaceuticals and illicit drugs in surface water by solid-phase extraction and ultra performance liquid chromatography–positive electrospray ionisation tandem mass spectrometry

Cited by 354 publications

References 35 publications

An overview of analytical methodologies for the determination of antibiotics in environmental waters

An overview of analytical methodologies for the determination of antibiotics in environmental waters

Pharmaceuticals and Hormones in the Environment

New Sample Preparation Strategies for Analytical Determinations

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