Multi-Responsive Optimization of Novel pH-Sensitive Hydrogel Beads Based on Basil Seed Mucilage, Alginate, and Magnetic Particles

Srikhao, Natwat; Chirochrapas, Korrapat; Kwansanei, Nessaraporn; Kasemsiri, Pornnapa; Ounkaew, Artjima; Okhawilai, Manunya; Likitaporn, Chutiwat; Theerakulpisut, Somnuk; Uyama, Hiroshi

doi:10.3390/gels8050274

Cited by 10 publications

(5 citation statements)

References 60 publications

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“…For example, some studies have investigated the development of a new drug delivery system to decrease side effects and increase the efficiency of drug delivery based on the manufacture of hydrogel beads for use as a basil seed mucilage (BSM)-based drug delivery system and sodium alginate (SA) [ 61 ]; as well, another study developed a pH-sensitive hydrogel system based on fenugreek seed mucilage, extracted from Trigonella foenum-graecum seeds, to improve the oral bioavailability of methotrexate (MTX) [ 62 ]. In the same line of research, research has studied contact lenses as drug delivery media and the effect of physiological tear pH on drug release behavior [ 63 ].…”

Section: Basic Concepts Of Hydrogels In Biomedicinementioning

confidence: 99%

Advancements in the Use of Hydrogels for Regenerative Medicine: Properties and Biomedical Applications

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Cisterna

et al. 2022

International Journal of Biomaterials

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Due to their particular water absorption capacity, hydrogels are the most widely used scaffolds in biomedical studies to regenerate damaged tissue. Hydrogels can be used in tissue engineering to design scaffolds for three-dimensional cell culture, providing a novel alternative to the traditional two-dimensional cell culture as hydrogels have a three-dimensional biomimetic structure. This material property is crucial in regenerative medicine, especially for the nervous system, since it is a highly complex and delicate structure. Hydrogels can move quickly within the human body without physically disturbing the environment and possess essential biocompatible properties, as well as the ability to form a mimetic scaffold in situ. Therefore, hydrogels are perfect candidates for biomedical applications. Hydrogels represent a potential alternative to regenerating tissue lost after removing a brain tumor and/or brain injuries. This reason presents them as an exciting alternative to highly complex human physiological problems, such as injuries to the central nervous system and neurodegenerative disease.

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Section: Basic Concepts Of Hydrogels In Biomedicinementioning

confidence: 99%

Advancements in the Use of Hydrogels for Regenerative Medicine: Properties and Biomedical Applications

Revete

Aparicio

Cisterna

et al. 2022

International Journal of Biomaterials

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“…Basil seed mucilage (BSM) has a heteropolysaccharide structure consisting of glucomannan and (1,4)-linked xylan, along with minor amounts of uronic acid [33,34]. BSM has low toxicity and high viscosity with pseudoplastic character and is being studied as a novel hydrocolloid in the food industry to improve texture and resistance to aging, stabilize emulsions, and enhance water retention [33][34][35]. However, following a survey of the existing literature, no study on the basil extract's ability to endow nanocellulose sponges with antimicrobial properties while preserving their biocompatibility for wound healing applications has been reported so far.…”

Section: Introductionmentioning

confidence: 99%

Nanocellulose Sponges Containing Antibacterial Basil Extract

Oprică

Panaitescu

Uşurelu

et al. 2023

IJMS

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Nanocellulose (NC) is a valuable material in tissue engineering, wound dressing, and drug delivery, but its lack of antimicrobial activity is a major drawback for these applications. In this work, basil ethanolic extract (BE) and basil seed mucilage (BSM) were used to endow nanocellulose with antibacterial activity. NC/BE and NC/BE/BSM sponges were obtained from nanocellulose suspensions and different amounts of BE and BSM after freeze-drying. Regardless of the BE or BSM content, the sponges started to decompose at a lower temperature due to the presence of highly volatile active compounds in BE. A SEM investigation revealed an opened-cell structure and nanofibrillar morphology for all the sponges, while highly impregnated nanofibers were observed by SEM in NC/BE sponges with higher amounts of BE. A quantitative evaluation of the porous morphology by microcomputer tomography showed that the open porosity of the sponges varied between 70% and 82%, being lower in the sponges with higher BE/BSM content due to the impregnation of cellulose nanofibers with BE/BSM, which led to smaller pores. The addition of BE increased the specific compression strength of the NC/BE sponges, with a higher amount of BE having a stronger effect. A slight inhibition of S. aureus growth was observed in the NC/BE sponges with a higher amount of BE, and no effect was observed in the unmodified NC. In addition, the NC/BE sponge with the highest amount of BE and the best antibacterial effect in the series showed no cytotoxic effect and did not interfere with the normal development of the L929 cell line, similar to the unmodified NC. This work uses a simple, straightforward method to obtain highly porous nanocellulose structures containing antibacterial basil extract for use in biomedical applications.

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“…Adding both water-soluble and water-insoluble substances can modify the physical properties of the CA gel beads. Water-soluble substances, such as hydrophilic macromolecules [ 14 , 15 , 16 , 17 , 18 , 19 , 20 ], can increase drug entrapment efficiency (DEE), swelling property, and drug release of the CA gel beads. The alternative approach for modulating the CA gel bead properties is the incorporation of water-insoluble substances.…”

Section: Introductionmentioning

confidence: 99%

Sodium Alginate-Quaternary Polymethacrylate Composites: Characterization of Dispersions and Calcium Ion Cross-Linked Gel Beads

Khunawattanakul

Jaipakdee

Rongthong

et al. 2022

Gels

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The objective of this work was to examine the effect of quaternary polymethacrylate (QPM), a water-insoluble polymer with a positive charge, on the characteristics of the sodium alginate (SA) dispersions and the calcium alginate (CA) gel beads containing propranolol HCl (PPN). The SA-QPM composite dispersions presented the formation of flocculates with a negative charge due to the electrostatic interaction of both substances. The QPM addition did not affect the SA dispersions’ Newtonian flow, but the composite dispersions’ viscosity enhancement was found. The PPN-loaded CA-QPM gel beads had more spherical than the PPN-loaded CA gel beads. The incorporation of QPM caused a bigger particle size, higher drug entrapment efficiency, and greater particle strength of the gel beads. Despite the similar water uptake property, the PPN-loaded CA-QPM gel beads displayed lower burst release and slower drug release rate than the PPN-loaded CA gel beads. However, the drug release from the PPN-loaded CA-QPM gel beads involved drug diffusion and matrix swelling mechanisms. This study demonstrated that adding QPM into the SA dispersions leads to a viscosity synergism. The CA-QPM gel beads display a good potential for use as a bioactive compound delivery system.

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Multi-Responsive Optimization of Novel pH-Sensitive Hydrogel Beads Based on Basil Seed Mucilage, Alginate, and Magnetic Particles

Cited by 10 publications

References 60 publications

Advancements in the Use of Hydrogels for Regenerative Medicine: Properties and Biomedical Applications

Advancements in the Use of Hydrogels for Regenerative Medicine: Properties and Biomedical Applications

Nanocellulose Sponges Containing Antibacterial Basil Extract

Sodium Alginate-Quaternary Polymethacrylate Composites: Characterization of Dispersions and Calcium Ion Cross-Linked Gel Beads

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