Multi-walled carbon nanotube polysaccharide modified Hericium erinaceus polysaccharide as an adjuvant to extend immune responses

Ren, Zhe; Luo, Yang; Meng, Zhen; Zhang, Junwen; Yu, Ruijin; Sun, Mengke; Xu, Ting; Li, Jian; Ma, Yufang; Huang, Yifan; Qin, Tao

doi:10.1016/j.ijbiomac.2021.03.180

Cited by 17 publications

(5 citation statements)

References 42 publications

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“…CS-MWCNT encapsulating Hericium erinaceus polysaccharide (HEP), an immunostimulant promoted the expression of MHCII, CD86, F4/80 and gp38 in mice peritoneal macrophages. Moreover, CS-MWCNT-HEP immunized mice significantly lengthened IgG immune response and cytokines levels [ 112 ].…”

Section: Cbm Vaccines and Immunotherapiesmentioning

confidence: 99%

Nanotechnology in the COVID-19 era: Carbon-based nanomaterials as a promising solution

Papi

Spirito

Palmieri

2023

Carbon

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Section: Cbm Vaccines and Immunotherapiesmentioning

confidence: 99%

Nanotechnology in the COVID-19 era: Carbon-based nanomaterials as a promising solution

Papi

Spirito

Palmieri

2023

Carbon

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“…[122] In contrast, the CD8 + T cells eliminate the virus-infected cells and generate antiviral cytokines, for example, interferon gamma (IFN-γ), which could better defend against primary and secondary viral infections. [123] Ren et al [124] attempted a different strategy to improve the immune response using drugs-functionalized CNTs. They reported that the Hericium erinaceus polysaccharide (HEP) loaded on Chitosan-MWCNTs (CS-MWCNTs) effectively regulated the immune response and promoted the expression of major histocompatibility complex class II (MHCII), CD86, F4/80, and gp38.…”

Section: Roles Of Cnts-based Materials In Enhancing Immune Responsementioning

confidence: 99%

“…Ren et al [124] . attempted a different strategy to improve the immune response using drugs‐functionalized CNTs.…”

Section: Applications Of Cnts In the Prevention Of Covid‐19mentioning

confidence: 99%

COVID‐19: Prevention, Detection, and Treatment by Using Carbon Nanotubes‐Based Materials

et al. 2023

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The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was responsible for the outbreak of coronavirus disease . The respiratory illness has rapidly spread worldwide and has claimed millions of lives. Although most countries have entered the endemic phase, health authorities warned that future variants could be more virulent than the existing ones. Since clinical trials of antiviral drugs for COVID-19 may last even a year before approval, developing alternative approaches to combat the virus becomes mandatory. Previ-ously, carbon nanotubes (CNTs) have exhibited an impressive track record in controlling numerous viral diseases, including COVID-19. In this article, we review recent applications of CNTs for the prevention, detection, and treatment of COVID-19. We highlight the strategies and prospective developments of CNTs in producing personal protection equipment (PPE), vaccines, immune-triggering, development of biosensors and therapeutic strategies. Finally, the challenges, limitations, and future outlook of CNTs in combating COVID-19 are also discussed.

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“…It has been reported that Chinese yam polysaccharides have a molecular weight of 16,619 Da and mainly consist of β-1,3-linked glucose, α-1-linked galactose, and α-1,6-linked galactose . However, Chinese yam polysaccharides have some disadvantages in clinical applications including a short half-life. , …”

Section: Introductionmentioning

confidence: 99%

“…17 However, Chinese yam polysaccharides have some disadvantages in clinical applications including a short half-life. 18,19 With the widespread biomedical application of particlestabilized emulsion (Pickering emulsion), the adjuvant potential of Pickering emulsions has received considerable attention. As a biocompatible and biodegradable biomaterial, poly (lactic-co-glycolic acid) (PLGA) has been widely employed in the fabrication of Pickering emulsions.…”

Section: ■ Introductionmentioning

confidence: 99%

Cationic Nanoparticle-Stabilized Vaccine Delivery System for the H9N2 Vaccine to Promote Immune Response in Chickens

Zhang

Zhu

et al. 2023

Mol. Pharmaceutics

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Chinese yam polysaccharides (CYPs) have received wide attention for their immunomodulatory activity. Our previous studies had discovered that the Chinese yam polysaccharide PLGA-stabilized Pickering emulsion (CYP-PPAS) can serve as an efficient adjuvant to trigger powerful humoral and cellular immunity. Recently, positively charged nano-adjuvants are easily taken up by antigen-presenting cells, potentially resulting in lysosomal escape, the promotion of antigen cross-presentation, and the induction of CD8 T-cell response. However, reports on the practical application of cationic Pickering emulsions as adjuvants are very limited. Considering the economic damage and public-health risks caused by the H9N2 influenza virus, it is urgent to develop an effective adjuvant for boosting humoral and cellular immunity against influenza virus infection. Here, we applied polyethyleneimine-modified Chinese yam polysaccharide PLGA nanoparticles as particle stabilizers and squalene as the oil core to fabricate a positively charged nanoparticle-stabilized Pickering emulsion adjuvant system (PEI-CYP-PPAS). The cationic Pickering emulsion of PEI-CYP-PPAS was utilized as an adjuvant for the H9N2 Avian influenza vaccine, and the adjuvant activity was compared with the Pickering emulsion of CYP-PPAS and the commercial adjuvant (aluminum adjuvant). The PEI-CYP-PPAS, with a size of about 1164.66 nm and a ζ potential of 33.23 mV, could increase the H9N2 antigen loading efficiency by 83.99%. After vaccination with Pickering emulsions based on H9N2 vaccines, PEI-CYP-PPAS generated higher HI titers and stronger IgG antibodies than CYP-PPAS and Alum and increased the immune organ index of the spleen and bursa of Fabricius without immune organ injury. Moreover, treatment with PEI-CYP-PPAS/H9N2 induced CD4+ and CD8+ T-cell activation, a high lymphocyte proliferation index, and increased cytokine expression of IL-4, IL-6, and IFN-γ. Thus, compared with the CYP-PPAS and aluminum adjuvant, the cationic nanoparticle-stabilized vaccine delivery system of PEI-CYP-PPAS was an effective adjuvant for H9N2 vaccination to elicit powerful humoral and cellular immune responses.

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Multi-walled carbon nanotube polysaccharide modified Hericium erinaceus polysaccharide as an adjuvant to extend immune responses

Cited by 17 publications

References 42 publications

Nanotechnology in the COVID-19 era: Carbon-based nanomaterials as a promising solution

Nanotechnology in the COVID-19 era: Carbon-based nanomaterials as a promising solution

COVID‐19: Prevention, Detection, and Treatment by Using Carbon Nanotubes‐Based Materials

Cationic Nanoparticle-Stabilized Vaccine Delivery System for the H9N2 Vaccine to Promote Immune Response in Chickens

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