Multi‐wavelength, handheld laser speckle imaging for skin evaluation

Zieger, Michael; Kaatz, Martin; Springer, S.; Riesenberg, Rainer; Wuttig, Andreas; Kanka, Mario; Stanca, Sarmiza Elena; Reble, Carina; Khazaka, Georg; Sieg, Robin; Gregorio, Marco De; Sattler, Martin; Fischer, F.

doi:10.1111/srt.12959

Cited by 10 publications

(9 citation statements)

References 25 publications

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“…Most importantly, it is difficult to detect them early and to adequately assess the effects and progress of their treatment. Autofluorescence is one of the techniques that could be used as a potential tool for assessing biochemical changes related to oral cavity disorders [ 49 ]. It enables the detection of lesions, especially at the early stage of their development.…”

Section: Discussionmentioning

confidence: 99%

Fractal Dimension and Texture Analysis of Lesion Autofluorescence in the Evaluation of Oral Lichen Planus Treatment Effectiveness

et al. 2021

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Background: Oral Lichen planus (OLP) is a chronic inflammatory disease. Topical steroids are used as the treatment of choice. The alternative is photodynamic therapy (PDT). The study aimed to fabricate optimal biodegradable matrices for methylene blue or triamcinolone acetonide because of a lack of currently commercially available carriers that could adhere to the mucous. Methods: The study was designed as a 12-week single-blind prospective randomized clinical trial with 30 patients, full contralateral split-mouth design. Matrices for steroid and photosensitizer and laser device were fabricated. Fractal and texture analysis of photographs, taken in 405, 450, 405 + 450 nm wavelength, of lesions was performed to increase the objectivity of the assessment of treatment. Results: We achieved two total responses for treatment in case of steroid therapy and one in the case of PDT. Partial response was noted in 17 lesions treated using local steroid therapy and 21 in the case of PDT. No statistically significant differences were found between the effectiveness of both used methods. Statistically significant differences in fractal dimension before and after treatment were observed only in the analysis of photographs taken in 405 + 450 nm wavelength. Conclusions: Photodynamic therapy and topical steroid therapy are effective methods for treating OLP. Using a carrier offers the possibility of a more predictable and effective method of drug delivery into the mucous membrane. Autofluorescence enables the detection of lesions especially at the early stage of their development.

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Section: Discussionmentioning

confidence: 99%

Fractal Dimension and Texture Analysis of Lesion Autofluorescence in the Evaluation of Oral Lichen Planus Treatment Effectiveness

et al. 2021

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“…There is a need to develop fair‐priced, miniaturized on‐site diagnostic systems that enable uncomplicated, quick, and precise diagnostic of the skin 21 . The multi‐wavelength, spectral imaging device developed is a step to reliable, precise, mobile, and inexpensive devices that can be used in dermatology, cosmetics, and research, and may help to improve medical care.…”

Section: Discussionmentioning

confidence: 99%

Mobile snapshot hyperspectral imaging device for skin evaluation using diffractive optical elements

Kern¹,

Speck²,

Riesenberg

et al. 2021

Skin Research and Technology

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Reflection spectroscopy is known as a non-invasive technology for the evaluation of healthy 1-5 and diseased human skin. 6,7 Recently, for both applications, the combination of spectroscopy and imaging within one device was introduced as hyperspectral imaging. 8 The goal of spectral imaging (SI) is to obtain the spectrum for each coordinate in the image of a scene by a single shot. Several acquisition techniques and applications of hyperspectral imaging were described. 9 There are four basic techniques for acquiring the three-dimensional (x, y, λ) dataset of a hyperspectral cube: spatial scanning, spectral scanning, non-scanning, and spatio-spectral scanning. 9 The choice of technique depends on the specific application, seeing that each technique has context-dependent advantages and disadvantages. Various main applications are described, including agriculture, food processing, mineralogy, or surveillance and environment.

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“…Laser speckle contrast imaging (SIM BFI HR Pro, Wuhan XunWei Optoelectronic Technology Co., Ltd.) was used to monitor blood perfusion in the pustule area 15,16 . After anaesthesia, mice were placed 20 ~ 30 cm below the stereo microscope until clear images were obtained.…”

Section: Methodsmentioning

confidence: 99%

“…Laser speckle contrast imaging (SIM BFI HR Pro, Wuhan XunWei Optoelectronic Technology Co., Ltd.) was used to monitor blood perfusion in the pustule area. 15,16 After anaesthesia, mice were placed 20 ~ 30 cm below the stereo microscope until clear images were obtained. Real-time blood flow images were then collected with an acquisition time of 15 s. The LED intensity was set at 4000 times, the optical multiple at 12 times and the brightness at level 5.5.…”

Section: Laser Speckle Contrast Imagingmentioning

confidence: 99%

Dynamic evaluation of pathological changes in a mouse acne model by optical imaging technology

Sun

Ren

et al. 2023

Experimental Dermatology

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Acne vulgaris is a disorder of the pilosebaceous unit that is primarily caused by hyperseborrhoea, colonization with Propionibacterium acnes, hyperkeratosis and an inflammatory response. Existing pharmacodynamic assessment methods primarily focus on a single causative factor at a certain time point, making it difficult to assess multiple factors simultaneously in real time. Therefore, it is crucial to establish a dynamic and nondestructive method for the assessment of acne in vivo. This study utilized four‐dimensional optical imaging techniques to assess the pathogenic factors and pathological progression of acne. LSCI was employed to measure blood flow; TPEF was used to observe inflammatory changes (NAD(P)H) in epidermal granular layer cells and structural changes in collagen fibres in the dermal layer. Additionally, the dermatoscope was used to investigate the micro‐characterization of the lesions. We observed that the epidermis in the lesion area was thickened, hair follicles were keratinized, and there was obvious inflammation and blood flow aggregation by optical imaging technology. Based on these findings, the pathological progression of this acne model could be divided into the inflammation phase, accompanied by bacterial colonization, and the reparative phase. These results provide a new perspective for the assessment of acne and offer an experimental basis for the selection of precise drugs for clinical use.

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Multi‐wavelength, handheld laser speckle imaging for skin evaluation

Cited by 10 publications

References 25 publications

Fractal Dimension and Texture Analysis of Lesion Autofluorescence in the Evaluation of Oral Lichen Planus Treatment Effectiveness

Fractal Dimension and Texture Analysis of Lesion Autofluorescence in the Evaluation of Oral Lichen Planus Treatment Effectiveness

Mobile snapshot hyperspectral imaging device for skin evaluation using diffractive optical elements

Dynamic evaluation of pathological changes in a mouse acne model by optical imaging technology

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