2015
DOI: 10.1016/j.aquatox.2014.11.004
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Multibiomarker assessment of cerium dioxide nanoparticle (nCeO2) sublethal effects on two freshwater invertebrates, Dreissena polymorpha and Gammarus roeseli

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Cited by 45 publications
(30 citation statements)
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“…However, due to a reduced dataset, this model has no predictive value, and should only be considered for its ability to synthetize and describe links between nanoparticle exposition and biomarker responses. Of the seven biomarkers identified, three were of particular significance (p<0.05; piGST mRNA levels, catalase activity, and hemocyte lysosomal system size) confirming our previous results (Garaud et al, 2015).…”
Section: Biological Effects Of Nceosupporting
confidence: 89%
See 2 more Smart Citations
“…However, due to a reduced dataset, this model has no predictive value, and should only be considered for its ability to synthetize and describe links between nanoparticle exposition and biomarker responses. Of the seven biomarkers identified, three were of particular significance (p<0.05; piGST mRNA levels, catalase activity, and hemocyte lysosomal system size) confirming our previous results (Garaud et al, 2015).…”
Section: Biological Effects Of Nceosupporting
confidence: 89%
“…We recently stressed the benefit of using integrated biomarker responses to study nCeO 2 effects and to identify biomarkers of interest (Garaud et al, 2015). In the present work, a very synthetic overview of the effects of nCeO 2 on mussel biology was provided using discriminant analysis and we were able i) to clearly differentiate control groups from nCeO 2exposed groups, ii) to show differential responses depending on nCeO 2 type and iii) to identify a reduced set of biomarkers sufficient to discriminate groups and their respective significance.…”
Section: Biological Effects Of Nceomentioning
confidence: 99%
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“…Acid phosphatase (ACP), lipid peroxidation (LOOH), lactate dehydrogenase (LDH), electron transport system (ETS) and energy reserves were measured on the S1 fractions, while total antioxidant capacity (TAC), catalase (CAT), glutathione peroxidase (GPxtot), and glutathione S-transferase (GST), caspase-3 (CASP-3) were measured on the cytosolic fraction (S2) by an automated colorimetric methods developed on the Konelab 20-XTi (Thermo Scientific) (Garaud et al, 2015(Garaud et al, , 2016. All technical procedures are described in detail in the Supplementary material.…”
Section: Energy Reserves Detoxification and Lipid Peroxidation (Lpo)mentioning
confidence: 99%
“…locomotion) responses, are appropriate tools to investigate sub-lethal effects and determine mechanisms of actions of AgNPs in aquatic invertebrates (Lagadic, 2002;Moore et al, 2004). These biomarkers are known to be early warning indicators used as a diagnostic or predictive tool for long-term effects that could occur at individual and/or population level (Garaud et al, 2015(Garaud et al, , 2016Jemec et al, 2008;Lagadic, 2002;Ulm et al, 2015;Vasseur and Leguille, 2004).…”
Section: Introductionmentioning
confidence: 98%