Multicellular scale front-to-rear polarity in collective migration

Capuana, Lavinia; Boström, Astrid; Etienne-Manneville, Sandrine

doi:10.1016/j.ceb.2019.10.001

Cited by 45 publications

(43 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The choice of a leader cell and establishment of its polarity is far from clear. The asymmetric distribution of cadherin-based adhesions may contribute to coordination of collective migration by restricting lamellipodial activity in the zones of cell-cell contacts and recruiting Rac GEFs at the leading cell edge [203]. Activation of leader cells depends on extracellular stimuli, such as ECM ligands or growth factors from microenvironment [201].…”

Section: Mesenchymal Migrationmentioning

confidence: 99%

Phenotypic Plasticity of Cancer Cells Based on Remodeling of the Actin Cytoskeleton and Adhesive Structures

Rubtsova¹,

Zhitnyak²,

Gloushankova³

2021

IJMS

View full text Add to dashboard Cite

There is ample evidence that, instead of a binary switch, epithelial-mesenchymal transition (EMT) in cancer results in a flexible array of phenotypes, each one uniquely suited to a stage in the invasion-metastasis cascade. The phenotypic plasticity of epithelium-derived cancer cells gives them an edge in surviving and thriving in alien environments. This review describes in detail the actin cytoskeleton and E-cadherin-based adherens junction rearrangements that cancer cells need to implement in order to achieve the advantageous epithelial/mesenchymal phenotype and plasticity of migratory phenotypes that can arise from partial EMT.

show abstract

Section: Mesenchymal Migrationmentioning

confidence: 99%

Phenotypic Plasticity of Cancer Cells Based on Remodeling of the Actin Cytoskeleton and Adhesive Structures

Rubtsova¹,

Zhitnyak²,

Gloushankova³

2021

IJMS

View full text Add to dashboard Cite

show abstract

“…Very much like drivers following road signs. Many inputs (e.g., chemical, mechanical, electrical, topological) can be shown to fulfill this function in controlled and simplified experiments (Zhao et al, 2006;Capuana et al, 2020;Zhu et al, 2020). However, living systems were not engineered by a designer to strictly follow a set of specifications in a logical manner that is then validated by external quality controls.…”

Section: Introductionmentioning

confidence: 99%

In vivo Neural Crest Cell Migration Is Controlled by “Mixotaxis”

Barriga

Théveneau

2020

Front. Physiol.

View full text Add to dashboard Cite

Directed cell migration is essential all along an individual’s life, from embryogenesis to tissue repair and cancer metastasis. Thus, due to its biomedical relevance, directed cell migration is currently under intense research. Directed cell migration has been shown to be driven by an assortment of external biasing cues, ranging from gradients of soluble (chemotaxis) to bound (haptotaxis) molecules. In addition to molecular gradients, gradients of mechanical properties (duro/mechanotaxis), electric fields (electro/galvanotaxis) as well as iterative biases in the environment topology (ratchetaxis) have been shown to be able to direct cell migration. Since cells migrating in vivo are exposed to a challenging environment composed of a convolution of biochemical, biophysical, and topological cues, it is highly unlikely that cell migration would be guided by an individual type of “taxis.” This is especially true since numerous molecular players involved in the cellular response to these biasing cues are often recycled, serving as sensor or transducer of both biochemical and biophysical signals. In this review, we confront literature on Xenopus cephalic neural crest cells with that of other cell types to discuss the relevance of the current categorization of cell guidance strategies. Furthermore, we emphasize that while studying individual biasing signals is informative, the hard truth is that cells migrate by performing a sort of “mixotaxis,” where they integrate and coordinate multiple inputs through shared molecular effectors to ensure robustness of directed cell motion.

show abstract

“…Close cellular contacts probably facilitate the propagation of direct mechanical and biochemical interactions that underlie supracellular migration. We tentatively distinguish “information flows” that propagate in either a back-to-front or a front-to-back fashion 12, 13 . For instance, similar to Xenopus cranial neural crest cells, Ciona cardiopharyngeal progenitors appear to focus contractility at the back of the trailer cell, thus suggesting that a “rear-wheel” engine may help power their migration.…”

Section: Discussionmentioning

confidence: 99%

“…Migratory collectives typically exist on a continuum with varying degrees of cell-cell contacts and collective polarity, where defined leader and follower cells are arranged in a front-to-back manner 12, 13 . In minimally differentiated groups, individual cells move as autonomous units, while adjusting directionality and speed relative to their neighbors 14 .…”

Section: Introductionmentioning

confidence: 99%

Supracellular organization confers directionality and mechanical potency to migrating pairs of cardiopharyngeal progenitor cells

Bernadskaya

Yue

Copos

et al. 2021

Preprint

View full text Add to dashboard Cite

Physiological and pathological morphogenetic events involve a wide array of collective movements, suggesting that these multicellular arrangements confer biochemical and biomechanical properties that contribute to tissue scale organization. The cardiopharyngeal progenitors of the tunicate Ciona provide the simplest possible model of collective cell migration. They form cohesive bilateral cell pairs, leader-trailer polarized along the migration path as they migrate between the ventral epidermis and trunk endoderm. Here, circumventing difficulties in quantifying cellular mechanics in live embryos, we use the Cellular Potts Model to computationally probe the distributions of forces consistent with the shapes and collective polarity of migrating cell pairs. Combining computational modeling, confocal microscopy, and molecular perturbations, we first determine that cardiopharyngeal progenitors display hallmarks of supracellular organization, with differential distributions of protrusive forces, cell-matrix adhesion, and myosin-based retraction forces along the leader-trailer axis. Combined 4D simulations and experimental observations suggest that cell-cell communication helps establish a hierarchy that contributes to aligning collective polarity with the direction of migration, as observed with three or more cells both in silico and in vivo. Our approach reveals emerging properties of the migrating collective. Specifically, cell pairs are more persistent, thus migrating over longer distances, and presumably with higher accuracy. Finally, simulations suggest that polarized cell pairs literally join forces to deform the trunk endoderm, as they migrate through the extracellular space. We thus propose that the polarized supracellular organization of cardiopharyngeal progenitors confers emergent physical properties that determine mechanical interactions with their environment during morphogenesis.

show abstract

Multicellular scale front-to-rear polarity in collective migration

Cited by 45 publications

References 55 publications

Phenotypic Plasticity of Cancer Cells Based on Remodeling of the Actin Cytoskeleton and Adhesive Structures

Phenotypic Plasticity of Cancer Cells Based on Remodeling of the Actin Cytoskeleton and Adhesive Structures

In vivo Neural Crest Cell Migration Is Controlled by “Mixotaxis”

Supracellular organization confers directionality and mechanical potency to migrating pairs of cardiopharyngeal progenitor cells

Contact Info

Product

Resources

About