Multicentric giant cell tumor: report of five new cases

Abstract

The typical giant cell tumor (GCT) is a solitary neoplams that occurs in the epiphysis or epimetaphysis of long bones. GCT is seen with a slightly increased frequency in females, and 70% of patients are between 20 and 40 years of age at the time of presentation. Multicentric giant cell tumor (MGCT; two or more centers) is an unusual variant of GCT. Patients with MGCT are likely to be younger than those with a solitary lesion. The multicentric variety is often of a higher stage at diagnosis and is more often associated with a pathological fracture than the unifocal tumor. We are reporting five new cases of MGCT, with a total of 21 tumors seen over a period of 25 years from 1967 to 1992.

Giant cell tumor of bone: treatment and outcome of 214 cases

“…In our series as well as in the former literature approximately 1% of GCTB present as multiple synchronous or metachronous lesions (Haskell et al 2003;Hindman et al 1994;Hoch et al 2006;Leggon et al 2004;Taraporvala et al 1997;Taylor et al 2003). As reported by several authors, patients with multicentric GCTB are likely to be younger than those with a solitary lesion (Hindman et al 1994;Hoch et al 2006).…”

“…As reported by several authors, patients with multicentric GCTB are likely to be younger than those with a solitary lesion (Hindman et al 1994;Hoch et al 2006). According to Hoch et al (2006) 59% of the patients are younger than 20 years of age.…”

Metachronous multicentric giant-cell tumor of the bone in the lower limb. Case report and Ki-67 immunohistochemistry study

“…Multicentric GCTs are extremely rare and represent less than 1% of GCTs [32]. Fewer than 60 cases have been reported in the literature [2,3,7,8,9,10,11,12,13,14,15,16,17,19,20,21,22,23,24,25,26,27,29,30,31,33,35,36]. Therefore, the pathogenesis of multiple benign lesions is still a matter of debate [22].…”

Multicentric Giant Cell Tumor of Ipsilateral Acetabulum and Femoral Head With Pathological Fracture of Femoral Neck: A Case Report

“…[6] Giant cell tumors are solitary lesions; less than 1% is multicentric. [8,9,10] Multicentric Giant cell tumor (MCGCT) is more aggressive and has propensity for small bones of hand and feet. Patients with Multicentric Giant cell tumor tend to be younger [11] as in our case.…”