Multicentric reticulohistiocytosis a review of eight cases

Catterall, M. D.

doi:10.1111/j.1365-2230.1980.tb01705.x

Cited by 60 publications

(28 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Of the 27 individually described cases of MRH presenting with dermatomyositis-like features, 7 (26%) were associated with malignancy [5,11,14,15,22,26], which is essentially equivalent to the previously reported rate of 25% in classic MRH [1]. Therefore, having dermatomyositis-like features did not have an increased association with malignancy.…”

Section: Discussionsupporting

confidence: 60%

See 1 more Smart Citation

Multicentric Reticulohistiocytosis with Dermatomyositis-Like Features: A More Common Disease Presentation than Previously Thought

Fett

Liu

2011

Dermatology

View full text Add to dashboard Cite

Multicentric reticulohistiocytosis (MRH) is a rare form of non-Langerhans histiocytosis that presents with erosive arthritis and skin nodules. Approximately 25% of patients with MRH have an associated malignancy. Dermatomyositis is an inflammatory autoimmune condition that has also been associated with malignancy. To date, 7 cases of MRH have been reported to present with cutaneous features of dermatomyositis. We describe an eighth patient with MRH who presented with dermatomyositis-like features (V-neck erythema, shawl sign, Gottron’s papules and periungual erythema), who developed metastatic breast cancer 1 year after diagnosis. We hypothesized that clinical overlap between MRH and dermatomyositis was not as uncommon as review of the literature suggested. Careful review of the physical exam findings and photographs of the 234 papers reporting MRH revealed 27 cases of MRH with dermatomyositis-like features. Of these 27 cases, 7 (26%) were associated with a malignancy. Skin biopsies of the cutaneous features mimicking dermatomyositis revealed pathologic features of MRH. This is a descriptive analysis of published case reports. Based on a review of published case reports, MRH presenting with dermatomyositis-like features is likely fairly common. Histological examination of skin biopsies allows for disease differentiation. Differentiating MRH from dermatomyositis is important for management decisions and comorbidity screening.

show abstract

Section: Discussionsupporting

confidence: 60%

“…All patients had biopsies consistent with MRH. Using these methods, 27 cases of MRH with dermatomyositis-like features were identified (table 1) [4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27]. …”

Section: Discussionmentioning

confidence: 99%

Multicentric Reticulohistiocytosis with Dermatomyositis-Like Features: A More Common Disease Presentation than Previously Thought

Fett

Liu

2011

Dermatology

View full text Add to dashboard Cite

show abstract

“…Diffuse photodistributed erythema in MRH similar to DM may be an early sign followed by the typical skin lesions [4,5,6,7, 22, 23]. We do not have any explanation for the reported photodistribution and photosensitivity of the skin lesions in these patients.…”

Section: Discussionmentioning

confidence: 73%

“…A cephalocaudal distribution of the nodules has been described [2] and sometimes a diffuse, irritable erythema or severe pruritus precedes the appearance of the more characteristic nodules [4,5,6,7]. Other atypical findings in MRH are hypochromic plaques [8], telangiectasias [9, 10], deep nodules [11,12,13,14], erythroderma[15] and neurofibroma-like nodules [16].…”

Section: Discussionmentioning

confidence: 99%

Multicentric Reticulohistiocytosis-Mimicking Dermatomyositis

Muñoz‐Santos¹,

Sàbat²,

A³

et al. 2007

Dermatology

View full text Add to dashboard Cite

Multicentric reticulohistiocytosis is a rare disorder of unknown etiology, characterized by skin and mucosal papulonodular eruptions and destructive polyarthritis. Histopathological study of these lesions shows a nodular infiltrate composed of histiocytes and multinucleated giant cells, with an eosinophilic, granular, ‘ground-glass’ cytoplasm. We report a case of multicentric reticulohistiocytosis with skin lesions mimicking dermatomyositis and we also review previously reported cases describing such a clinical situation. Our case further emphasizes that multicentric reticulohistiocytosis can mimic clinical features of dermatomyositis. A macular or patch-like erythema in a photodistributed fashion, in addition to other clinical manifestations, can be mistaken for dermatomyositis. However, skin biopsies from these areas may early differentiate both conditions with different treatment options and morbidity.

show abstract

“…The methods and expression of the results were as previously described (2). We found significant inhibitory activity (10% reduction in response) in 17 of the 19 SF samples.…”

Section: To the Editormentioning

confidence: 93%

Multicentric reticulohistiocytosis in a 9‐year‐old boy

Omdal¹,

Lærdal²,

Kjellevold³

1988

Arthritis & Rheumatism

View full text Add to dashboard Cite

LETTERSsevere stomatitis, and the drug was discontinued for 14 days. Naproxen, which had been given concomitantly with MTX, was reduced to 375 mglday. When MTX was reinstituted at lower weekly doses (5 mg or 7.5 mg), stomatitis recurred; however, the RA continued to respond very well to the drug. He received a total of 52.5 mg of MTX before it was again discontinued.Because he experienced severe stomatitis with 5-mg doses of injectable MTX, it was considered that oral MTX would likewise produce stomatitis. However, this change in the mode of drug administration was tried, along with the addition of leucovorin to the treatment regimen. A regimen of 5 mg of oral MTX taken at 8 AM once a week, followed by 5 mg of leucovorin 14-16 hours later, was begun. He had no stomatitis with that regimen, and the MTX dosage was later increased to 7.5 mg/week, without adverse effects. He has been on this regimen for the last 10 months and has had approximately 95% improvement, as judged by both his self-reported symptoms and his physical examination results. Hematologic and biochemical studies have not indicated any adverse effects.This case illustrates that an intolerable side effect from MTX, severe stomatitis, can be abrogated by leucovorin, allowing the patient to continue taking MTX. Because this patient noticed rapid (somewhat early) symptomatic improvement with only a few, low doses of MTX, an interesting question arises as to the correlation, if any, with his early development of severe stomatitis.

show abstract

Multicentric reticulohistiocytosis a review of eight cases

Cited by 60 publications

References 10 publications

Multicentric Reticulohistiocytosis with Dermatomyositis-Like Features: A More Common Disease Presentation than Previously Thought

Multicentric Reticulohistiocytosis with Dermatomyositis-Like Features: A More Common Disease Presentation than Previously Thought

Multicentric Reticulohistiocytosis-Mimicking Dermatomyositis

Multicentric reticulohistiocytosis in a 9‐year‐old boy

Contact Info

Product

Resources

About