Multicentric reticulohistiocytosis in a child

Raphael, Steven; Cowdery, Susan L.; Faerber, Eric N.; Lischner, Harold W.; Schumacher, Harold R.; Tourtellotte, Charles D.

doi:10.1016/s0022-3476(89)80795-4

Cited by 15 publications

(5 citation statements)

References 11 publications

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“…The erosions spread centrally and cause separation of the bony areas [ 8 ]. Osteoporosis has not been described, but osteopenia was found in our patient and was reported in a 14 year old African American girl [ 9 ]. There can be compromise of the atlantoaxial joint causing subluxation and instability.…”

Section: Discussionmentioning

confidence: 61%

Papular xanthomas and erosive arthritis in a 3 year old girl, is this a new MRH variant?

et al. 2009

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Xanthomatous skin lesions and arthritis in children are not a common association. We present the case of a 3 year old girl who presented with xanthomatous lesions in the periungual region of both hands, around the nares and on her forehead, associated with significant arthritis that was clinically compatible with multicentric reticulohistiocytosis. However, pathology of the xanthomatous lesions was more suggestive of papular xanthoma, a disease that is not associated with arthritis. Based on her presentation and the negative lipid workup, she was treated for presumed multicentric reticulohistiocytosis. Multiple treatment strategies were utilized, with improvement on a combination of infliximab, methotrexate, and prednisone. We review the different diagnoses that should be considered in children with xanthomas and arthritis as well as the different pharmacologic therapies used in children with multicentric reticulohistiocytosis.

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Section: Discussionmentioning

confidence: 61%

Papular xanthomas and erosive arthritis in a 3 year old girl, is this a new MRH variant?

et al. 2009

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“…MRH usually begins in the fourth decade of life (6), however, multiple cases have been reported with an onset in childhood or adolescence (2,7–14). Eighty‐five percent of the reported adults were Caucasian, which is similar to the reports in children, although other races can be affected.…”

Section: Discussionmentioning

confidence: 99%

Multicentric Reticulohistiocytosis in a 14‐Year‐Old Girl

Outland¹,

Keiran²,

Schikler

et al. 2002

Pediatric Dermatology

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Multicentric reticulohistiocytosis is a rare multisystem disorder in which an infiltration of histiocytic cells causes papulonodular skin lesions and potentially a destructive polyarthritis. The active disease typically resolves spontaneously after 5-8 years, but the articular destruction can lead to permanent joint deformities. We present a case of multicentric reticulohistiocytosis in a 14-year-old girl. The number of papules on her hands decreased in number and her arthritic symptoms improved after 4 months of oral naproxen. Thirty months later her joint symptoms remained inactive and only six very small papules remained on her hands. Small flexor deformities were present in the distal interphalangeal joints of both index fingers. This case is an example of how multicentric reticulohistiocytosis can be a relatively stable and self-limited disease but still cause permanent joint deformities.

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“…MR affects women three times more often than men. It primarily afflicts middle‐aged individuals, rarely striking children or adolescents 2 . Sixty percent of patients have polyarthritis.…”

Section: Discussionmentioning

confidence: 99%