Multicommuted flow system employing pinch solenoid valves and micro-pumps

Lavorante, André F.; Pires, Cherrine K.; Reis, Boaventura F.

doi:10.1016/j.jpba.2006.04.013

Cited by 43 publications

(14 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…); an electronic interface with power and current intensity sufficient to drive the valves and micro-pumps; [29][30][31][32][33] a homemade reaction chamber; two glass-cylinders, 20 mm long with a diameter of 2.0 mm; one blue LED (λ = 435 nm); a photodiode (Burr Brown © , OPT301, Tucson, AZ, USA); transistor BD547; and resistors. Vol.…”

Section: Instrumentationmentioning

confidence: 99%

“…The system manifold is constituted of a set of solenoid valves, 29,30 and a peristaltic pump or several solenoid micro-pumps employed to propel the solutions. [31][32][33] The manifold, constituted of solenoid valves 30 or solenoid mini-pumps, [31][32][33] is controlled by a microcomputer in order to insert the sample slugs and the reagent solution into the analytical path. This resource was used in order to reduce both reagent consumption and waste generation.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A multicommuted flow analysis method for the photometric determination of amoxicillin in pharmaceutical formulations using a diazo coupling reaction

Freitas¹,

Silva²,

Araújo³

et al. 2011

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

Neste trabalho foi proposto um método de análise em fluxo por multicomutação para a determinação de amoxicilina em formulações farmacêuticas. O método proposto é baseado na reação de diazotização da o-nitroanilina com amoxicilina em meio alcalino, produzindo um composto amarelo que foi monitorado em 435 nm. As características do método foram: faixa linear de 25 até 400 mg L -1 de amoxicilina, limite de detecção de 5,1 mg L -1 , frequência analítica de 50 determinações por hora e desvio padrão relativo inferior a 3,9% (n = 10) para uma amostra típica de 100 mg L -1 amoxicilina. Para verificar a exatidão do método, as amostras foram analisadas empregando um método independente e aplicando-se o teste-t pareado não houve diferença significativa no nível de confiança de 95%.A multicommuted flow analysis method for the spectrophotometric determination of amoxicillin in pharmaceutical formulations is reported. The proposed method is based on the reaction of diazotised o-nitroaniline with amoxicillin in an alkaline medium, producing a yellow compound that was monitored at 435 nm. The main features of the method were: a linear relationship with amoxicillin concentration ranging from 25 to 400 mg L -1 ; a detection limit of 5.1 mg L -1; an analytical throughput of 50 determinations per hour; and a relative standard deviation lower than 3.9% for a typical amoxicillin sample with concentration of 100 mg L -1 (n = 10). To verify the accuracy of the method, samples were also analyzed employing an independent method, and applying the paired t-test to the results no significant difference at the 95% confidence level was observed.

show abstract

Section: Instrumentationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A multicommuted flow analysis method for the photometric determination of amoxicillin in pharmaceutical formulations using a diazo coupling reaction

Freitas¹,

Silva²,

Araújo³

et al. 2011

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

show abstract

“…Many assays have been described for AAP, including titrimetry, chromatography, fluorometry, colorimetry ultraviolet (UV) spectrophotometry, and various modes of electrochemistry [8]. Determination of AAP using spectrophotometric methods and pulse perturbation technique was also described [9][10][11]. Electrochemical detection and cyclic voltammetric determination of AAP were reported [8,12].…”

Section: Introductionmentioning

confidence: 99%

Determination of analgesics in pharmaceutical formulations and urine samples using nano polypyrrole modified glassy carbon electrode

Muralidharan

Gopalakrishnan

Vedhi³

et al. 2009

J Appl Electrochem

View full text Add to dashboard Cite

Three analgesics (acetaminophen, acetylsalicylic acid, and dipyrone) were determined electrochemically using nano polypyrrole modified glassy carbon electrode. The cyclic voltammetric behavior of the three analgesics was studied in aqueous acid, neutral, and alkaline conditions. One well-defined oxidation peak each for acetaminophen and acetylsalicylic acid and three oxidation peaks for dipyrone were observed in the cyclic voltammograms. The influence of pH, scan rate, and concentration reveal the irreversible diffusion controlled loss of 4e -in acid and neutral media and 2e -/1H ? in basic medium for acetaminophen. In the case of acetylsalicylic acid, 2e -and 1H ? loss in acidic and neutral pH and 2e -and 2H ? loss in basic pH were observed and the oxidation was irreversible and controlled by adsorption. Irreversible removal of 2e -and 1H ? in all pH media was observed for dipyrone and the oxidation was controlled by diffusion. A systematic study of the experimental parameters that affect the differential pulse stripping voltammetric response was carried out and optimized conditions which yield maximum peak current were arrived at. Scanning electron microscopy (SEM) analysis confirms good accumulation of the drugs on the electrode surface. The calibration was made under optimum conditions. The range of study for acetaminophen, acetylsalicylic acid, and dipyrone was 50-250, 40-300, and 100-400 ng/mL and the lower limit of determination was 45, 25, and 70 ng/mL respectively. The suitability of the method for the determination of the three analgesics in pharmaceutical preparations and urine samples was also ascertained.

show abstract

“…17 In this work a micro-pumping flow system was developed using a Light Emitting Diode LED based photometer and a home-made flow cell with an optical path-length of 100 mm for the determination of selenium in water. The method is based on the reaction of selenium with potassium iodide to liberate iodine, and the oxidation of Variamine Blue to form a violet-coloured species.…”

Section: Introductionmentioning

confidence: 99%

Multi-pumping mechanised determination of selenium in natural waters by light emitting diode (LED) spectrometry

Fernandes¹,

Reis²,

Morales‐Rubio³

et al. 2009

J. Braz. Chem. Soc.

Self Cite

View full text Add to dashboard Cite

Um procedimento para determinação de selênio em águas, completamente mecanizado, foi desenvolvido empregando um fotômetro baseado em LED e mini-bombas solenóide como dispositivos de propulsão. O método proposto é baseado na reação de selênio com iodeto de potássio em meio ácido para liberar iodo, o qual oxida a variamina azul formando um composto violeta que absorve em 530 nm. O sistema foi mecanizado empregando o processo de multicomutação em fluxo e uma estratégia de parada de fluxo na etapa final para desenvolvimento da reação. A curva analítica foi linear entre as concentrações de 0,010 a 0,500 mg L , respectivamente. A freqüência de amostragem foi de 23 determinações por hora, e a exatidão foi de 95% de probabilidade.It has been developed a fully mechanised procedure for the determination of selenium in waters employing a LED based spectrometer and solenoid multi-pumps as solution propelling devices. The proposed method is based on the reaction of selenium with potassium iodide in an acidic medium to liberate iodine, which oxidizes Variamine Blue to form a violet-colour species which absorb at 530 nm. The system was mechanised using the multicommutation process and a stopped flow strategy in the final step reaction. The analytical curve was linear between 0.010 and 0.500 mg L . The relative standard deviation for Se solutions of 0.050 and 0.200 mg L -1 (n = 4) were 1.6 and 1.8% respectively, the sampling throughput was 23 determinations per hour, and accuracy was 95% probability level.

show abstract

Multicommuted flow system employing pinch solenoid valves and micro-pumps

Cited by 43 publications

References 34 publications

A multicommuted flow analysis method for the photometric determination of amoxicillin in pharmaceutical formulations using a diazo coupling reaction

A multicommuted flow analysis method for the photometric determination of amoxicillin in pharmaceutical formulations using a diazo coupling reaction

Determination of analgesics in pharmaceutical formulations and urine samples using nano polypyrrole modified glassy carbon electrode

Multi-pumping mechanised determination of selenium in natural waters by light emitting diode (LED) spectrometry

Contact Info

Product

Resources

About