Multicomponent assembly of novel antiproliferative steroidal dihydropyridinyl spirooxindoles

Visible‐Light‐Mediated Dearomatisation of Indoles and Pyrroles to Pharmaceuticals and Pesticides

“…Notably, the dearomatised product ( 1 b ) from indole can be transformed into an anticancer compound ( 34 b ) by reacting with 2‐aminobenzenethiol at 85 °C . Furthermore, we were able to transfer 5‐chloroindole to the corresponding steroid based antitumour compound ( 35 b ) . Additionally, 1 H ‐indole was transformed into an anticonvulsant and anti‐inflammatory compound ( 36 b ) through dearomatisation and the addition of aniline .…”

“…[20] Furthermore, we were able to transfer 5-chloroindole to the corresponding steroid based antitumour compound (35 b). [21] Additionally, 1H-indole was transformed into an anticonvulsant and anti-inflammatory compound (36 b) through dearomatisation and the addition of aniline. [22] Furthermore, this anti-inflammatory compound (36 b) was transformed into antiviral compound (37 b) in the presence of additional indole.…”

Recent applications of isatin in the synthesis of organic compounds

“…131 MTT assay indicated that some of these compounds exhibited moderate to excellent cytotoxic activity against the tested cancer cell lines. The cytotoxic activities varied greatly depending on the position and electronic nature of substituents on the isatin nucleus and N-benzyl moieties.…”

The Development of Biologically Important Spirooxindoles as New Antimicrobial Agents

“…Spirooxindole (Highlighted in red in Fig. 1) containing compounds have exhibited diverse biological properties, such as anticancer [16][17][18][19][20][21], antimicrobial [22,23], antivirus [24], etc. Representative examples are NITD609 (also known as Cipargamin) [25], CFI-400945 (the first PLK4 inhibitor) [26,27], SAR405838 (MDM2 inhibitor) [28,29] and APG-115 (MDM2 inhibitor) Fig.…”