Multicomponent eco-friendly synthesis of 3,4-dihydropyrimidine-2-(1H)-ones using an organocatalyst Lactic acid

An efficient method for the synthesis of 2,4,5-trisubstituted imidazoles using lactic acid as promoter

“…Lactic acid is obtained from fermentation of carbohydrates, it is easy to handle and readily available. Lactic acid is reported as organocatalyst in several organic reactions [39][40][41][42][43][44][45][46][47][48]. In the present method we are reporting lactic acid for the synthesis of 2,4,5-trisubstituted imidazole compounds from an aromatic aldehyde, benzil, and ammonium acetate under milder reaction conditions (160 °C) ( Fig.…”

Organocatalyzed Biginelli Reactions

“…The use of such catalysts is growing because they have low or no toxicity. Urea and thiourea were found to be suitable substrates in these reactions (Table 1) [12,13]. Organic acids are organocatalysts with all of such desired characteristics.…”

Organocatalytic clean synthesis of densely functionalized 4H-pyrans by bifunctional tetraethylammonium 2-(carbamoyl)benzoate using ball milling technique under mild conditions

“…Furthermore, organocatalysis, namely the use of small organic molecules to catalyze organic transformations, is a relatively new and popular field within the domain of organic synthesis. Once the field of organocatalysis had been publicly defined, it grew quickly (32)(33)(34)(35)(36)(37). Although the impact of transition-metal-based catalysts on chemical synthesis cannot be completely understated, some metal-based systems can be expensive, toxic, and sensitive to air or moisture (38)(39)(40).…”