Multicomponent Reactions

Abstract

Multicomponent Reactions appear to be ideal for any form of synthesis, because of their numerous advantages in terms of sustainability and selectivity in building up complex molecular architectures, with high molecular diversity. This Special Issue collects seven contributions which expand our knowledge about Multicomponent Reactions, providing a good overview about innovative reactivities and applications.

One‐pot synthesis of novel polysubstituted furopyran derivatives via pseudo seven‐component reaction (6 + 1) of isocyanides with bisarylidene Meldrum's acid containing ether groups

“…S C H E M E 2 Structure of synthesized products Moreover, three signals at δ = 29.34, 29.46, and 29.92 ppm were associated with methyl carbons along methylene carbons at δ = 66.5 ppm. 15 N NMR spectrum of 5a exhibited three signals at 199.97, 205.65, and 346.27 ppm in the imine region. [36] This is conformed furopyran structure and consistent with three molecules of isocyanide being incorporated into the product (supporting information).…”

“…These reactions are thus regarded as a useful tool for one‐pot synthesis of complex and diverse composites in addition to small and drug‐like heterocycles . Given the importance of MCRs, several reviews have been reported in recent years …”

“…[12] Given the importance of MCRs, several reviews have been reported in recent years. [13][14][15][16][17] One of the most significant and large classes of MCRs are isocyanide-based MCRs (IMCRs), initially introduced by Passerini in 1921. [18][19][20][21][22] An important advantage of MCRs based on isocyandes is their affinity with an extensive range of ancillary functional groups absent in the starting MCR processes.…”

Novel pseudopolymeric magnetic nanoparticles as a hydrogen bond catalyst for the synthesis of tetrahydrodipyrazolopyridine derivatives under mild reaction conditions

“…[12][13][14][15][16][17] Several practical benefits connected with multicomponent reactions including bond forming competence, atom and step economy, omission of intermediary purification process, low cost of the separation and purification protocol for achieving to pure target molecules, and scarce waste formation in the course of reactions, solvents, reagents, time, and energy conserving make this synthetic strategy as an ideal tool in hands of chemists for the synthesis of structurally complicated molecules. [18][19][20][21] In recent years, due to abovementioned reasons, the effective applications of multicomponent reactions for the synthesis of valuable heterocyclic molecules have been well reviewed. [22][23][24][25] Due to co-existence of two biological active moieties, namely, pyrazole and 1,4-dihydropyridine within the structure of tetrahydrodipyrazolopyridines, these versatile molecules represent varied pharmaceutical applications such as anxiolytic, antiallergic, and antiherpetic behavior.…”

Facile Synthesis of 5,6,7,8-tetrahydropyrimido[4,5-d] pyrimidine-2,4 (1H,3H) -dione Analogs via One Pot Multicomponent Reaction

“…Thus, MCRs can be used to quickly generate the SARs (structure-activity relationships [2][3][4][5][6][7][8]. Any form of compounds can be synthesize with their high bond-forming efficacy and atom economy, unusual waste formation and the purification and separation of products are economical while using MCRs [9]. MCRs are the masterworks of reaction designs and synthetic efficiency [10,11].…”