Multicomponent Reactions with Isocyanides

Abstract

Multicomponent reactions (MCRs) are fundamentally different from two‐component reactions in several aspects. Among the MCRs, those with isocyanides have developed into popular organic‐chemical reactions in the pharmaceutical industry for the preparation of compound libraries of low‐molecular druglike compounds. With a small set of starting materials, very large libraries can be built up within a short time, which can then be used for research on medicinal substances. Due to the intensive research of the last few years, many new backbone types have become accessible. MCRs are also increasingly being employed in the total synthesis of natural products. MCRs and especially MCRs with isocyanides offer many opportunities to attain new reactions and basic structures. However, this requires that the chemist learns the “language” of MCRs, something that this review wishes to stimulate.

Isonitrile Hydratase from Pseudomonas putidaN19–2

“…carbon monoxide (1). The isocyano group exhibits the unusual characteristic that it reacts with nucleophiles and electrophiles on the same carbon atom of the functional group, which has been exploited for synthetic applications (1); in particular, isocyanide-based multicomponent reactions are a powerful tool for the one-pot synthesis of diverse and complex compounds and are being increasingly used for the discovery of new drugs and agrochemicals (2)(3)(4).…”

Reaction Attempts Book

“…[6] The multicomponent design of the Ugi reaction and the simple reaction conditions make it ideal for exploring large virtual libraries and selecting compounds of interest to make. [7] Isolation of the Ugi products can be immensely simpler, cheaper and readily scalable if they precipitate in pure form from the reaction mixture. To this end, much of the research in the UsefulChem project focuses on reaction conditions that lead to this outcome.…”

Fe3O4@SiO2-OSO3H nanocomposite as an efficient catalyst for the preparation of tricarboxamides

“…17 MCRs often adapt to the goals of green chemistry connected to economy of reaction approaches as well as the many particular principles of favorable chemical transformations. [18][19][20] Due to of their benefits such as facile performance, environmentally friendly, fast and atom economic, MCRs interested great attention related to combinatorial chemistry. 21 Tricarboxamide derivatives are a class of nitrogen heterocyclic compounds which have significant and well-reported biological activities that include neuroprotective, 22 anti-diabetic, 23 antibacterial, 24 anti-carcinogenic 25 and anti-tumor activities.…”