2015
DOI: 10.1055/s-0034-1380237
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Multicomponent Synthesis of 3-Arylmethyl-2,5-diarylthiophenes

Abstract: Pseudo Five-Component Synthesis of 3-(Hetero)arylmethyl-2,5-di(hetero)aryl-Substituted Thiophenes via Sonogashira-Glaser Cyclization Sequence Synthesis 2014, 46, 3415-3422. Multicomponent Synthesis of 3-Arylmethyl-2,5-diarylthiophenes Significance: Reported is the synthesis of 3-arylmethyl-2,5-diarylthiophenes using a palladiumcatalyzed multicomponent reaction involving aryl iodides, thiophenols, and TMS acetylene. This reaction was initially developed using a sequential protocol with a solvent exchange, wh… Show more

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